Showing 101–125 of 200 documents
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Giller Db, Stepan Saenko, A. N. Gerasimov, G. V. Shcherbakova, A. A. Popova, et al.
…e effectiveness of surgical treatment in patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Materials and methods : We examined immediate treatment outcomes of 1180 patients who underwent surgery for destructive MDRTB, pre-XDR-TB, and …
Zhao,Jinyun, Mao,Weifang, Jin,Faxiang, Xu,Wenfang
…l zjy19871987@163.comObjective: This study aimed to analyze drug resistance patterns, mutation profiles in Mycobacterium tuberculosis isolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China.Methods: Clinical specimens and data from tuberculosis…
Akanksha Tomar, Rajesh Tiwari, Aditi Bharti
Abstract Background: Drug-resistant tuberculosis (DR-TB) can be a menace for TB elimination, making it crucial to identify the drivers of this multifaceted challenge. Now, as drug sensitivity results are available at the commencement of the treatment, DRTB patients can be delinea…
В. Н. Даниленко
…ssue of the growing morbidity and mortality caused by multi-drug-resistant (extreme drug-resistant) tuberculosis (TB). This issue is aggravated by the alarming rise of immunocompromized patients and immigration worldwide. In order to solve this problem, an interdisciplinary appro…
Martina L. Reichmuth, Kathrin Zürcher, Marie Ballif, Chloé Loiseau, Sònia Borrell, et al.
Abstract Background Drug-resistant Mycobacterium tuberculosis ( Mtb ) strains threaten tuberculosis (TB) control. We compared data on drug resistance obtained at clinics in seven high TB burden countries during routine care with whole-genome sequencing (WGS) carried out centrally…
Rashmi Jindal, Itu Singh, Sadhana Bhardwaj, Payal Chauhan
…n. However, an additional problem emerging is antimicrobial resistance (AMR) to anti-leprosy drugs, especially rifampicin that forms the backbone of WHO multi-drug therapy. WHO recommends testing for AMR in all relapse cases and a sample of new multibacillary (MB) cases.[2] Howev…
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…y of TB preventive treatment for persons exposed at home to drug-resistant tuberculosis (DR-TB) [[3]Brooks M N.E. Hussain H. Malik A. Jaswal M. Siddiqui S. Barry Z. Fuad J. Becerra M.C. Seddon J. Furin J. How to care for people exposed to drug-resistant tuberculosis: a practical …
Sora Yasri, Viroj Wiwanitkit
Emergence of drug-resistant tuberculosis has become an important public health problem at present[1]. In Indochina, especially for Myanmar and Thailand, the extensively drug-resistant Mycobacterium tuberculosis is an emerging problem[2]. The extensively drug-resistant M. tubercul…
N.V. Chumovatov, O.G. Komissarova, N.A. Chernykh
… was 9.9. million people. We also observed proliferation of drug-resistant TB. According to the WHO, 450,000 TB patients with multiple drug resistance (MDR) were registered worldwide in 2021, which exceeded the similar rate in 2020 by 3%. In the recent years we observed decrease …
Tingting Li
…, significantly compounded by the rising prevalence of multidrug-resistant (MDR-TB) and rifampicin-resistant (RR-TB) strains [1,2]. The cornerstone of effective TB management is timely and accurate diagnosis, yet the current gold standards for detecting drug resistance-molecular …
Ketema Tafess, Timothy Ting-Leung Ng, Hiu Yin Lao, Kenneth Siu Sing Leung, Kingsley King Gee Tam, et al.
…mergence of Mycobacterium tuberculosis strains with complex drug resistance profiles necessitates a rapid and extensive drug susceptibility test for comprehensive guidance of patient treatment. Here, we developed two targeted-sequencing workflows based on Illumina MiSeq and Nanop…
Sari Afiah Miyuki Rifani, Zen Ahmad, M. Yusri, Erial Bahar
…esia ranks third in tuberculosis cases, with 23,000 new dualdrug-resistant tuberculosis patients. The delay in predicting tuberculosis resistanceoccurs because sputum tools are not yet available. This study aimed to determinethe differences in chest x-rays for drug-sensitive mult…
Prerna Jasmine Kerketta
…s (TB) by 2025.So we need to have high adherence to anti-TB drugs. We conducted this study to know the adherence to second line drugs for drug-resistant TB. It was a prospective-observational study conducted from November 2022 to May 2024. After obtaining informed consent from th…
Thi-Kim-Thang Dao, Dao Dinh, Mai-Hien Chuc, Hai‐Anh Ha
…m 448 inpatient TB cases throughout 2022, encompassing both drug-sensitive and drug-resistant forms of TB. Analysis revealed that drug-resistant TB patients incur significantly higher treatment costs compared to those with drug-sensitive TB, with costs escalating further among ol…
Ehssan Moglad, Hisham N. Altayb
…tant pattern for different clinical isolates to control the resistance phenomena. This study was designed to provide the resistance pattern of isolated Staphylococcus spp. from various clinical samples in Khartoum State and to elucidate the frequencies of Multidrug-resistant (MDR…
Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu, et al.
Abstract Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5%…
Tong Chen, Tianchi Yang, Xiang Lin, Sijia Wang, Ping Guo-hua, et al.
ObjectiveTo evaluate the levels and patterns of drug resistance in initially treated smear-negative pulmonary tuberculosis (TB) patients in Ningbo, and provide scientific evidence for the prevention and control of drug-resistant TB. MethodsSputum samples of 1 434 initially treate…
Selma Zein Syafira, Nabilla Ghina Zavitri, Su Yan, Yunia Sribudiani, Alexander Lezhava, et al.
…olecular techniques, which detect mutations associated with drug resistance tuberculosis (TB), are promising technologies for rapid diagnosis and monitoring of drug-resistant TB. Pyrosequencing is a potential rapid and robust molecular technique to detect drug resistance but its …
Zhongchen Ma, Tianhao Sun, Xinyu Bai, Xiang Ji, Qian Zhang, et al.
Introduction In recent years, drug-resistant Mycobacterium tuberculosis strains have gradually become widespread. Most drug resistance is related to specific mutations. We investigated M. tuberculosis drug resistance in the Kashgar area, China. Methods The drug-susceptibility tes…
DK Mumena, Geoffrey Kwenda, CW Ngugi, AK Nyerere
Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia is highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from the new and previously treated cases of TB were examined for drug-resistant …
Saad Ahmed Jamal
…ases, 1.4 million deaths and nearly half a million cases of drug-resistant TB, in 2019. The need of the hour is to prevent the rise of drug resistance in TB. The rise in drug resistance can be mainly attributed to failure to adhere to treatment regimens. Recent studies show that …
Elmiawati Latifah, Endang Yuniarti, Rinto Susilo, Hidayah Karuniawati, Nur Azizah, et al.
Drug-resistant tuberculosis (TB) is a public health problem that poses major challenges to patients, health workers, society, and the health care system. This research is a qualitative study to explore the implementation of drug side-effect monitoring and the role of health worke…
Yi-Ran Han, Tianhao Wang, Wenping Gong, Jianqin Liang, Huiru An
…nical efficacy of thymopentin combined with antituberculous drugs in treating drug-resistant pulmonary TB (PTB).Methods: Relevant studies were retrieved from PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, and Wanfang Database. STATA software was u…
Heather Stone, Mili Duggal, Leonard Sacks, Mayurika Ghosh
Abstract Background Multi and extensively drug-resistant (MDR and XDR) tuberculosis (TB) remains a treatment challenge due to drug adverse events (AEs) and long regimens. Our aim was to identify AEs which resulted from repurposing drugs for MDR and XDR-TB. Methods A PubMed search…
Mandira Varma‐Basil, Mridula Bose
…tion assays. However, successful diagnosis and treatment of drug-resistant TB depend on not only rapid identification of MTB complex (MTBC) but also universal access to accurate drug susceptibility testing (DST). Conventionally, the diagnosis of drug resistance in MTB isolates ha…