Showing 76–100 of 200 documents
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Muhammad Shahzad
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious disease and major global public health problem. Recent evidence from animal studies suggests that the microbiome plays a role in TB pathogenesis and immune response. However, until now, no simil…
Veena Kiran Nambiar, H J GayathriDevi, Rachana Nayak
… the respiratory muscle strength in patients with pulmonary tuberculosis. <b>Participants:</b> Twenty six adults,newly diagnosed with pulmonary tuberculosis (Drug susceptible) visiting respiratory OPD consecutively. Age and gender matched subjects were recruited as controls. <b>M…
Jian Sun, Wenjie Wang, Jing Ding, Yusheng Cheng, Yunfeng Zhou, et al.
Abstract Background Duration of antituberculosis therapy (ATT) for managing female genital tuberculosis (FGTB) is controversial with the intermittent regimen no more advocated. We therefore conducted a prospective, real-world research to compare 6 months and 9 months of ATT. Meth…
Jian Sun, Wenjie Wang, Jing Ding, Yusheng Cheng, Yunfeng Zhou, et al.
Abstract Background Duration of antituberculosis therapy (ATT) for managing female genital tuberculosis (FGTB) is controversial with the intermittent regimen no more advocated. We therefore conducted a prospective, real-world research to compare 6 months and 9 months of ATT. Meth…
Huan Xia, Zaixing Pan, Yun Hong, Qingzhu Zhao, Weili Fan
… aimed to investigate the correlation between Mycobacterium tuberculosis (MTB) genotypes and the severity of pulmonary imaging, and to explore the application of artificial intelligence (AI) in assessing radiological severity in Hainan, China. In this retrospective study, MTB iso…
M. I. Romanova, E. V. Vаniev, D. O. Churkin, A. V. Abramchenko, А. I. Gayda, et al.
…otherapy for drug susceptible rapidly progressive pulmonary tuberculosis in a patient with systemic lupus erythematosus taking glucocorticosteroids on regular basis. Due to adverse events that occurred when using the regimen of first line drugs, the patient discontinued taking fi…
Muhammad Farman, Shahid Mehmood Malik, Ali Akgül, Nadeem Salamat
…millions of people die from the airborne infectious illness tuberculosis (TB). Several drug-susceptible (DS) and drug-resistant (DR) forms of the causative agent, Mycobacterium tuberculosis (MTB), are currently common in the majority of affluent and developing nations, particular…
Rhastin A D Castro, Amanda Ross, Lujeko Kamwela, Miriam Reinhard, Chloé Loiseau, et al.
…in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis ( Mtb ) affects the evolution of FQ-resistance (FQ-R). To investigate this question, we…
Kumari Neha, Jitender K Malik
One of the eldest human diseases is tuberculosis (TB), for which there is molecular evidence dating back more than 17,000 years. Unfortunately, TB is still one of the top 10 infectious diseases that kill people worldwide, second only to HIV, despite advances in detection and trea…
Phenlak Kaewthong, Pramote Tragulpiankit, Chareon Chuchottaworn, Sukanya Wattanapokayakit, Suppanut Prakongsup, et al.
…k factors of isoniazid mono-resistance among Thai pulmonary tuberculosis patients. The case-control study was conducted from 18 th September 2017 to 20 th February 2018. Demographic data were collected from medical record review and interview. NAT2 genotypes were collected from s…
Luanna de Ângelis Correia de Sousa, Ana Lúcia Figueiredo Porto, Giovanna Gabriela Pedroza Rodrigues, Jaqueline Rodrigues da Silva, Milena Brandão de Lima, et al.
Rifampicin (RIF) is one of the main drugs used to treat tuberculosis (TB), primarily caused by Mycobacterium tuberculosis (Mtb) and considered one of the world’s deadliest infectious diseases. However, RIF has limitations in solubility and stability, which compromises its therape…
Nurlilah Ab Rahman
Tuberculosis is a global disease that carries with it high health and socio-economic burdens onto populations. Millions of people come down with the active form of the disease every year but the proportion of the world population that carries the latent form of this disease is be…
Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Danielle Martiniano da Silva Rodrigues, Larissa Pereira Dantas da Silva, João Paulo de Lucena Laet, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the main global public health challenges, worsened by the emergence of strains resistant to conventional treatments. Levofloxacin (LEVO), a fluoroquinolone antibiotic, is an alternative for treating resistant…
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…alized airborne human intracellular pathogen, Mycobacterium tuberculosis ( Mtb ), causes the disease tuberculosis (TB), with one death per second and approximately 10 million cases per year worldwide. Mtb has emerged as a health risk due to its ability to adapt to drugs . The eme…
Novi Maulina, Zinatul Hayati, Zulkarnain Zulkarnain, Kartini Hasballah, Ika Waraztuty
Background: Tuberculosis (TB) remains one of the top ten causes of mortality worldwide. It is caused by a single infectious agent, Mycobacterium tuberculosis. Indonesia has the second highest cases globally and has a high burden of rifampicin-resistant (RR-TB). Xpert MTB/RIF has …
Soedarsono Soedarsono, Alvian Fauzi, Anita Widyoningroem, Ni Made Mertaniasih
Background: Drug-resistant (DR) pulmonary tuberculosis (TB) is often associated with morbidity and mortality compared to drug-susceptible (DS) pulmonary TB. The infectiveness and pathological destruction of DR TB and DS TB strains are still controversial. Objectives: This study a…
Cross, Gail
Tuberculosis (TB) treatment remains prolonged despite highly effective antimicrobial regimens, reflecting persistent host-mediated inflammation and tissue damage. Host-directed therapies (HDTs) have emerged as a complementary strategy to improve treatment response by modulating m…
Yang Zhou, Bing Zhao, Tao Li, Qian Cheng, Yanlin Zhao, et al.
This study reports an outbreak of Tuberculosis (TB) in a high school in Hunan province, China during January 2017-April 2018. Contact investigation and TB screening were conducted through symptom screening, tuberculin skin testing, chest radiography and smear examination. Identif…
Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosis received preventive tuberculosis t…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
Tuberculosis (TB) remains the most challenging infection to treat worldwide. The contemporary TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobac…
Grant Theron, PHD
… of the 1.7 billion individuals infected with Mycobacterium tuberculosis (Mtb) will progress to active tuberculosis (TB). This probability increases in people with human immunodeficiency virus (HIV) and other risk co-morbidities such as malnutrition, diabetes and substance abuse.…
Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
…>BACKGROUND</title> Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasibility of dif…
Pelumi Daniel Adewole, Ogundipe Tosin Deborah
Background: Tuberculosis remains a leading infectious cause of death.Drug resistant tuberculosis (DR-TB) which serves as a major problem for TB control thereby serves as a major hindrance to the recent achievements.Although, there has been an increase in TB and DR-TB cases, the g…
Sunday Olakunle Olarewaju, Sunday Charles Adeyemo, Ayomide Timilehin Kayode, Janet Oluwaseyi Ayinmodu, Olushina Ololade Oladeji, et al.
BACKGROUND: Tuberculosis (TB), an infectious disease caused by _Mycobacterium tuberculosis_ is still one of the leading public health problems, despite advances in the effort to reduce its incidence, morbidity, and mortality. Studies have shown that the prevalence of depression c…
Jamieson O’Marr, Crhistinne Cavalheiro Maymone Gonçalves, Denise Arakaki-Sánchez, Daniele Maria Pelissari, Fernanda Dockhorn Costa, et al.
Abstract Background Tuberculosis notifications in Latin American prisons have more than doubled over the past two decades; however, treatment outcomes and their determinants among incarcerated individuals in this region are not well understood. Methods Newly diagnosed drug-suscep…