Showing 76–100 of 200 documents
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Stefani Candra Firmanti, Rina Triasih, Tri Wibawa, Sofia Mubarika Haryana
BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to a…
Damla Sel Coban, Hıncal Özbakır, Berna Avci Yavuz, Berna Kahraman Çetin, Özlem Erdoğan, et al.
To the Editors: Tuberculosis (TB) remains a significant public health concern in children, particularly in endemic regions. However, diagnosis can be challenging due to other respiratory infections that present with similar clinical and radiological features. Here, we report the …
М. С. Опанасенко, O.V. Tereshkovich, S. М. Shalahai, L. І. Levanda, T.V. Kirillova
Pediatric surgeons often to have different indications for the diagnosis and treatment of pathology of the thoracic cavity. Often, only invasive techniques, such as a biopsy, can help diagnose and determine further treatment. One of the reasons for performing thoracic operations …
The Lancet Microbe
When approximately 40% of people who develop tuberculosis (4·2 million of an estimated 10·6 million people, in 2021, according to WHO) are not diagnosed, how can the widespread use of sputum smear microscopy for initial diagnosis—a method developed over a century ago—still be jus…
Brilliant Deva Aspada, Komang Agung Irianto Suryaningrat, Pudji Lestari, Primadenny Ariesa Airlangga
Spinal Tuberculosis is a secondary tuberculosis due to hematogenous spread from the primary infection site (lungs) caused by the bacteria Mycobacterium tuberculosis and is chronic-destructive in nature which attacks the spine. Manifestations in the form of deformity can also be c…
Daniel Edisha Garba, Uju Marie-Esther Dibua, Chiamaka Ukamaka Oka, Yvonne Ogechukwu Ozoadibe, Friday Attah, et al.
Urogenital tuberculosis (UGTB) is a common extrapulmonary manifestation of TB, but its diagnosis remains challenging due to nonspecific symptoms and limited diagnostic tools. Despite its significant impact on global health, it remains incompletely understood and often overlooked.…
Khondker Qamruzzaman, Syed Ahsan Tauhid, Dr. Md. Ashiqur Rahman, Sk Sadek Ali, Dr. Md. Nahidul Islam, et al.
Background: Pulmonary tuberculosis (PTB) remains a significant health issue in children. Early and accurate diagnosis is critical but challenging, The GeneXpert test, a rapid and accurate molecular diagnostic tool, has improved TB detection by identifying Mycobacterium tuberculos…
Made Winatra Satya Putra, Made Agus Maharjana, I Ketut Siki Kawiyana
Background: Tuberculosis of the bone is a serious problem in developing countries, extra-pulmonary tuberculosis is more common among children. The characteristics of tuberculosis osteomyelitis in children are different. Therefore, the disease is often neglected or diagnosis is de…
Meyer Children's Hospital IRCCS
…s were reported in 2020, of which 1 million occurred in the pediatric population. However, epidemiological data available on tuberculosis (TB) in pediatric age are extremely limited due to diagnostic challenges in this patient category. Furthermore, children are almost never incl…
Claudia Ozela El- Husny, Ângela Maria Rodrigues Ferreira, Jamilie Suelen dos Prazeres Campos, Kamila Nancy Gonçalves da Gama, Iací Proença Palmeira, et al.
Introduction: Tuberculosis control tools are a challenge to primary health care, due to the delay of people from the appearance of the first symptoms to the search for the first health-care service, and health-care services leading to difficulties and delay in establishing the di…
Deepmala Pandey, Ankur Yadav
Background: Body fluids are commonly used for diagnosis as sputum is not reliable in children. Hence it is essential to study efficacy of body fluids in comparison to GeneXpert which is a new diagnostic modality. Objectives of this study was to incidence of rifampicin resistance,…
Muhammad Ali Shodikin, Desie Dwi Wisudanti, Annisa Nadhifa Witanto
Background: Tuberculosis (TB) remains a major public health problem globally. TB in children is an important component in TB control. The diagnosis of TB in children until now is still challenging, underdiagnosis often occurs in primary health facilities in Indonesia. This study …
E. P. Еremenko, Е. А. Бородулина, I. A. Sergeeva, D.А. Kudlаy, B. E. Borodulin
…ests (Mantoux test with 2 TU PPD-L and diaskintest) for the diagnosis of tuberculosis infection, in vitro tests are used. One of these tests is T-SPOT.TB being more widely used in recent years. The objective : to evaluate the effectiveness of T-SPOT.TB test for early detection of…
Anastasia Y. Starshinova, И. Ф. Довгалюк, Ulia Ovchinnikova, Анна Старшинова, P. K. Yаblonskiy
<b>Introduction:</b> Early diagnosis of TB infection in children is complicated due to poor clinical signs, minor X-ray abnormalities, and absence of bacterial excression. Potential of Mantuox 2 TE test in population with common BCG vaccination is limited due to its low diagnosti…
Xiaoxia Wang, Shaomei Huang, Hua Chen
… clinical and Imaging characteristics between children with pediatric pulmonary tuberculosis (PTB) and children with pneumonia who were initially suspected of PTB, and to explore valuable indicators for differential diagnosis. Methods This retrospective study enrolled pediatric i…
Ana Alvarez, Mobeen H. Rathore
…ies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After…
Joana Vieira, Andreia Fiúza Ribeiro, Paula Correia, Helena Loureiro
Background: Tuberculosis disease under six years is an indicator of recent transmission within the community. We aim to characterize tuberculosis disease in children under six years in a pediatric department of a level II hospital in the Lisbon metropolitan area, which serves a h…
Robert Sinurat
Tuberculosis myelitis usually impacts adult patients and is associated with tuberculous meningitis, miliary tuberculosis, or human immunodeficiency virus infection. Pediatric tuberculosis myelitis cases without any associated diseases have never been reported. The author reported…
Caroline Lacroix, Philippe Martin, Sebastien Turcotte, Steven DeRoche, Vanessa Magluilo, et al.
…TION: Despite being more prevalent in developing countries, tuberculosis (TB) remains an important health problem in Canada. Long diagnosis delays of respiratory tuberculosis are associated with adverse consequences for the patient but also for the community. From a public health…
Bárbara Maitee Carmenates-Álvarez, Ana Dianelis Reyes-Escobar, Yosvany Rojas-Peláez, Yamilka Joamis Peña-Borroto, Yon Luis Trujillo-Pérez
Background: tuberculosis is a public health problem to a world scale. It is a systemic illness that can rarely affect the gastrointestinal tract and it is not very frequent in pediatrics. Its diagnosis constitutes a great challenge. Objective: to present the case of an adolescent…
SushantSatish Mane
Childhood tuberculosis (TB) is a grave problem, with nearly one-third of global pediatric TB cases being from India. In 2020, approximately one lakh TB cases (0–14 years of age) were reported to the National TB Elimination Program (NTEP), with around 1.4 lakh cases in the 15–18 y…
Halisyah Hasyim Lubis
Introduction: Drug-resistant tuberculosis (DR TB) is a condition where Mycobacterium tuberculosis is resistant to isoniazid, rifampicin or resistant to isoniazid and rifampin as well as other first-line anti-tuberculosis drugs (OAT). Tuberculosis (TB) is a contagious infectious d…
Venkatesh Karthik S., Jigisha Patadiya
Background: The diagnosis of tuberculosis (TB) by microbiological tests is a major challenge particularly in children. The use of Xpert analysis, a rapid genetic testing modality is not widely reported in our locality. The aim of the study to evaluate the diagnostic accuracy of G…
Ayesha Tariq, Muhammad Naeem
Background: The prevalence of rifampicin resistance in pediatric patients with Mycobacterium tuberculosis is a growing concern, particularly in regions with high TB burden. Early and accurate detection of drug resistance is crucial for effective treatment and management, especial…
Putu Ardy Hartadi, Putu Siska Suryaningsih
Tuberculosis (TB) in children is often difficult to diagnose due to nonspecific symptoms and limited microbiological testing. Severe anemia in children is usually evaluated for nutritional deficiencies or hematological disorders, but can also be an indicator of chronic infections…