Showing 76–87 of 87 documents
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Souleymane Mboup, Robert Wilkinson, Bernard Landry
…(immunogenicity analysis set). This Phase II multi-country trial was conducted as a randomized, double-blind, placebo-controlled trial in 650 HIV-positive adults with no evidence of active TB disease. Subjects were stratified at the time of randomization by whether or not they w…
Mercedes Yanes Lane, Anete Trajman, Mayara Lisboa Bastos, Olivia Oxlade, Chantal Valiquette, et al.
…scade of care for latent TB infection. A cluster randomized trial of a programmatic public health intervention to improve management of latent TB infection in household contacts was conducted in Rio de Janeiro. Interventions included contact registry, initial and in-service train…
Eve Denton, Peter Wark, Mark Hew
…gal burden. Observational studies and randomized controlled trials of azoles including Ketaconazole, Itrazonazole, Voriconazole and Posaconazole all show benefit, reducing exacerbations, steroid requirements and total IgE over time.7-9 However, side effects and drug interactions …
Mercedes Yanes‐Lane, Anete Trajman, Mayara Lisboa Bastos, Olivia Oxlade, Chantal Valiquette, et al.
…scade of care for latent TB infection. A cluster randomized trial of a programmatic public health intervention to improve management of latent TB infection in household contacts was conducted in Rio de Janeiro. Interventions included contact registry, initial and in-service train…
Amadou T LY
…mple size, and recruitment strategies for a future efficacy trial of vaccine candidate MTBVAC in young children. MTBVAC is a new TB vaccine candidate based on an attenuated clinical isolate of M. tuberculosis. The clinical development consortium of this EDCTP program is preparin…
Kamini Jain, Claire Wainwright, Alan R Smyth
… improve the selection of antimicrobials, which may lead to clinical benefits. This is an update of a previous review that was first published in 2013 and was updated in 2016 and in 2018. OBJECTIVES: To evaluate the use of bronchoscopy-guided (also known as bronchoscopy-directed)…
Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
…B) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasibility of different DR-TB case-finding strategies to inform research, policy, and practice,…
Andrew Schmidt, Ziad Bakouny, Chris Labaki, Babar Bashir, Jessica Clément, et al.
…re on COVID-19 severity in oncology patients from the CCC19 registry. Methods: The CCC19 registry (NCT04354701) was used to identify patients with prior BCG exposure. Cohort A received intravesical treatment for bladder carcinoma, and cohort B received prior BCG vaccination. Each…
Stephen Joseph, C Chen, N Smallcombe, Veronica White, Heinke Kunst
…ease. MDR-TB poses concern for clinicians due to its poorer clinical outcomes and public health implications. Current guidelines do not differentiate between contact tracing for MDR-TB and fully sensitive TB, nor do they recommend preventative treatment for MDR-TB contacts. <h3>M…
Angelique Luabeya, MD
…3 will enroll 9 subjects. This study is planned at a single clinical site in South Africa. The sizes specified for each study group were selected because they are judged to be adequate for preliminary safety and immunogenicity evaluations for a Phase I study rather than for stati…
Kashyap Surender, Bhardwaj Manisha
…culosis (TB) closely mimics sarcoidosis on epidemiological, clinical and radiological grounds. There is a high possibility of labelling a patient with sarcoidosis as tubercular, especially in TB endemic countries. Furthermore, sarcoidosis is a diagnosis of exclusion. It is impera…
Shivanthan Shanthikumar, Sarath Ranganathan, Melanie R. Neeland
… no effective anti-inflammatory therapies routinely used in clinical practice, however, significant resources are allocated to identifying such treatments.1 Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy is transforming the care of CF and is now used…