Showing 76–100 of 200 documents
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Allison Portnoy, Rebecca A. Clark, Matthew Quaife, Chathika K. Weerasuriya, Christinah Mukandavire, et al.
…liminating it has proven challenging. Safe and effective TB vaccines that can rapidly reduce disease burden are essential for achieving TB elimination. We assessed future costs, cost-savings, and cost-effectiveness of introducing novel TB vaccines in low- and middle-income countr…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Suraj B. Sable, Vijayakumar Velu, Andreas Kupz
…y mechanism of infection and immune modulation.Nucleic-acid vaccines offer a key advantage: rapid development and flexibility (11,12). A thorough review of DNA and RNA TB vaccines by Kazakova et al. https://doi.org/10.3389/fimmu.2024.1457327 (13) highlights their promise but also…
Helen McShane
…been immunised with various recombinant MVA investigational vaccines including constructs expressing malaria, HIV, hepatitis B and melanoma antigens without significant adverse reactions (Hill, unpublished data). Furthermore, 190 children aged 1-5 years were vaccinated with a rec…
Mohamed E. El Zowalaty, Hossam M. Ashour
…able protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB vaccine pipeline, as was reviewed elsewhere.2TuBerculosis Vaccine Initiative (TBVI)Pipeline of Vaccines.https://www.tbvi.eu/what-we-do/pipeline-of-vacci…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
Coronavirus Disease-2019 (COVID-19) has become a worldwide emergency and announced as a pandemic recently with variable incidence and mortality in different geographical areas.1 The relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigati…
Veli Sungono
… Building trained immunity Historically, researchers design vaccines by identifying the “perfect” antigen, molecules that generates long-term, infection-specific responses by the body’s immune system. This then provides immunity on re-encounter with the same disease-causing agent…
Gokhan Burul, Büşra Tuğçe Tonyalı, İstemi Serin
…dies on early post-HSCT administration of immunostimulatory vaccines have generally shown them to be safe; however, caution is warranted regarding inflammatory responses and increased reactogenicity [4]. In particular, in the presence of immune-modulating factors such as GVHD or …
Leonora Svarça, Sonja Bojadzieva, Premtim Rashiti, Albiona Rashiti
Vaccines are recognized as one of the most effective public health interventions. Routine immunization has resulted in large reductions in vaccine-preventable disease and death. Vaccine-related hypersensitivity reactions are not uncommon. The concern about the occurrence of hyper…
Helen McShane
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines induce both CD4+ and CD8+ T cells and thus offer a potential new approach to a TB vaccine. DNA vaccines encoding various antigens from M. tuberculosis have been evaluated in the murine model, and t…
Rhonita Schutz
Tuberculosis (TB) has many known risk factors that contribute to its persistence worldwide, particularly in developing countries. Aotearoa New Zealand (NZ), as a high-income country, is fortunate to fall in the low-risk category. However, the incidence of TB is more common in par…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
… for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to treating COVID-…
Gurudeeban Selvaraj, Satyavani Kaliamurthi, Dongqing Wei
…hus providing a promising foundation for next-generation TB vaccines (1). This work also exemplifies how integrating pathogen genomics with host response profiling can accelerate rational vaccine design.Building on the theme of precision, the second study focuses on cervical canc…
N.А. Matsegora, A.V. Kaprosh
…uding the AEC/BC02, Ad5 Ag85A and ChAdOx185A-MVA85A phase 1 vaccines, MTBVAC, ID93+GLA-SE, TB / FLU-04L and the GamB phase vaccine. 2a, amplifiers DAR-901, H56:IC31, M72/AS01, BCG revaccination and RUTI vaccine in phase 2b, VPM1002 and MIP/Immuvac in phase 3. Candidate TB vaccine…
Eleni I. Katsarou, George C. Fthenakis
…inst staphylococcal mastitis’ and ‘total number of optional vaccines administered’. Univariable and multivariable analyses were first performed to establish associations of each of the above outcomes with climatic variables. Then, the same approach was employed to assess the impo…
Puck T. Pelzer, Marit Holleman, Michelle E. H. Helinski, Ana Lúcia Weinberg, Pauline Beattie, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Sasheela Ponnampalavanar, Anjanna Kukreja, Sazali Basri, Sheron Sir Loon Goh, Syifa’ Ahmad Faisol, et al.
Background and objectives: Since the introduction of the COVID-19 vaccine through the National COVID-19 Immunization Program in Malaysia in February 2021, the number of cases of severe COVID-19 and mortality have progressively decreased. We explored the association between vaccin…
Veronika A. Petrova, Leyla S. Namazova-Baranova, Мarina V. Fedoseenko, Dina S. Rusinova
…). It has also been shown that timely vaccination with both vaccines in the early neonatal period significantly reduces the risk of AD in general infant population compared to non-vaccinated individuals or those who had only one vaccine (odds ratio [OR] 0.374; 95% confidence inte…
Akhil Sharma, Shaweta Sharma, Mobeen Shaik, Hrithik Dey, Pankaj Agrawal
…including influenza, COVID-19, or tuberculosis, traditional vaccines such as oral formulations and injections have limitations in effectively targeting these pathogens. However, the solution to this challenge lies in the development of inhalable vaccines. Inhalable vaccines take …
Ting Huang, Master
…esign. In this trial, 160 subjects were enrolled. The test vaccines are divided into four dose groups: dose group 1 (0.025mg / 0.1ml / person), dose group 2 (0.05mg / 0.1ml / person), dose group 3 (0.075mg / 0.1ml / person), dose group 4 (0.1mg / 0.1ml / person), each Each dose …
Mark Hatherill, MD, FCPaed
…as been excluded. Clinical trials of new viral-vectored TB vaccines, including MVA85A, a modified vaccinia virus Ankara (MVA) vaccine expressing the Mycobacterium tuberculosis antigen 85A, have to date enrolled infants who were already vaccinated with routine BCG at birth. Howev…
Renee Gresh, Kimberly Davidow, Jeff Myers, D Morley
Abstract Introduction: It is well known that children with cancer are at an increased risk of severe influenza infections due to immunosuppression and co-morbidities. Serious influenza infections can lead to increased hospitalizations, outpatient visits, and delays in treatment. …
Fabiola Silva-Angulo, Henao-Tamayo, Marcela, Weir, Tiffany, Abdo, Zaid, Izzo, Angelo
Tuberculosis is an infectious lung disease responsible for approximately 1.4 million human deaths, world-wide every year. The causal agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), has been estimated to latently infect one-third of the human population. Curre…
Viktoria A. Minaeva, Alla A. Golubkova
BACKGROUND: Reducing population immunity to vaccine-controlled infections because of low vaccination coverage at any moment could destabilize earlier epidemiological well-being against vaccine-controlled infections in the context of the COVID-19 pandemic. AIM: This study comprehe…
National Institute of Allergy and Infectious Diseases (NIAID)
This study will assess the safety of a Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis (TB) and will evaluate if giving the vaccine by mouth, injection, or by both methods produces greater results. BCG vaccine and/or placebo (substance containing no medication) will b…