Showing 76–100 of 200 documents
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Aarav Sinha, Jothsna Kethar, Dr.Rajagopal Appavu
Drug-resistant tuberculosis (TB) poses a significant global health challenge, affecting millions worldwide. Annually, around half a million individuals develop drug-resistant TB, underscoring the urgency of addressing this issue. Treating drug-resistant TB is complex and lengthy,…
Anil Regmi, Bishwa Bandhu Niraula, Abdus Sami, Vijay Kumar Jain, Gayatri Vishwakarma, et al.
Multidrug-resistant (MDR), pre-extensively drug-resistant (pre-XDR), and extensively drug-resistant (XDR) strains are associated with delayed diagnosis, protracted therapy, and increased morbidity. This article aims to systematically review the clinical spectrum, diagnostic strat…
Robin Varughese John, Hafiz Deshmukh, Sunil Jadhav, Ashish Deshmukh, Shivprasad Kasat, et al.
OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have register…
Jalil Kardan-Yamchi, Hossein Kazemian, Arash Ghodousi, Daniela María Cirillo, Masoumeh Douraghi, et al.
Aims and objectives: Treatment of patients with drug-resistant tuberculosis is time-consuming and requires expensive drugs with more toxicity. Proper and timely identification of drug-resistant genotypes and determining the minimum inhibitory concentrations (MICs) alongside with …
Tawsifur Rahman, Amith Khandakar, Ashiqur Rahman, Susu M. Zughaier, Muna Al Maslamani, et al.
… and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infectio…
Vinayak Talwar, Abhishek Sadasivan
…e global TB elimination without TB elimination in SEAR, and drug resistance is a significant obstacle to the elimination of TB.[4] Drug-resistant TB is brought on by either the spread of Mycobacterium tuberculosis strains that are already resistant or by the inadequate treatment …
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, et al.
…mains a global health concern because of the development of drug resistance. The adaptability of MTB in response to a variety of environmental stresses is a crucial strategy that supports their survival and evades host defense mechanisms. Stress regulates gene expression, particu…
Callistus A. Akinleye, Adekola O. Adekunle, A. Onabule, Olugbenga Adekunle Olowe, Olusoji Daniel
… tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a sign…
Parissa Farnia, Ali Akbar Velayati
With worldwide increases of rifampicin resistance, the World Health Organization (WHO) comes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who …
Mandira Varma‐Basil
Aims and objectives: Multidrug resistant TB (MDR-TB) and extensively drug resistant (XDR) are responsible for significant obstruction to global control of tuberculosis (TB). Drug resistance in Mycobacterium tuberculosis mainly occurs through chromosomal mutations in genes encodin…
Ifrah Amjad, Saba Riaz
…rganisms. Microorganisms have noteworthy amplitude to offer resistance to antimicrobial agents and becoming an awful public health plight. The rising probability of infections is attributed to the ability of microbes conferring drug resistance. Drug resistance is a horrible capac…
A. A. Zhurilo, A. I. Barbova
The continued rise in the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis in the era of human immunodeficiency virus infection poses a serious threat to effective tuberculosis control. Drug resistance in M. tuberculosis occurs due to lowfrequency spo…
Noorsuzana Mohd Shariff, Shamsul Azhar Shah, Fadzilah Kamaludin
…ients had a significant contribution to the transmission of drug-resistant tuberculosis in the community. However, little is known about the profile of foreign-born drug-resistant patients in Malaysia, and this has become the aims of this current study. Methods and materials: Thi…
Durgadevi Ravi, Vishwanath kaliyaperumal, Bhuvaneswari Gunasekar, Shyamaladevi Babu
… health crisis, with millions of cases and deaths annually. Drug-resistant strains like multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB further complicate treatment. Conventional TB treatment, reliant on lengthy drug regimens, faces issues of non-compliance, dru…
Yitagesu Habtu, Tesema Bereku, Girma Alemu, Ermias Abera
…iopia is one of among thirty high burden countries of multi-drug resistant tuberculosis (MDR-TB) in the regions of world health organization. Contextual evidence on the emergence of the disease is limited at a program level. </sec> <sec> <title>OBJECTIVE</title> The aim of the st…
Balaji Zacharia, Antony Roy
…the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
…evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB)…
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
ABSTRACT Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the prim…
Kyla Sherwood, Shom Dasgupta-Tsinikas, David L Fuller
Abstract Background Prompt identification of drug-resistant tuberculosis (DR-TB) is crucial for the timely initiation of effective therapy, but phenotypic drug susceptibility testing (pDST) takes weeks to provide results. Advanced molecular drug susceptibility testing (mDST) allo…
Dirie AMH, S Çolakoğlu, Abdulle OM, Abdi BM, Osman MA, et al.
…ospital, Mogadishu, Banadir, Somalia; 2Manager of the Multi-Drug Resistant Center in Southern Somalia, Mogadishu, Banadir, Somalia; 3HIV Program manager, Ministry of Health, Somali Federal Government, Mogadishu, Banadir, Somalia; 4Infectious and Microbiology Department, Somalia M…
Askar Zetov, Kulakhmed Erimbetov, Nargiza Parpieva, Bolat Zhetibayev, Abzal Malbaskanov
… a surgical approach in treatment of multi- and extensively drug-resistant tuberculosis.Design:The article described a retrospective analysis of surgical treatment of 246 multi- and extensively drug-resistant tuberculosis patients who were divided into 3 groups: 152 multi-drug-re…
Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez, Alma R. Soriano-Herrera, et al.
…es worldwide. New diagnostic tools and approaches to detect drug-resistance must be introduced by 2025 to achieve the End-TB Strategy goals set for 2030 by the WHO. Genomic epidemiology of TB has allowed the expansion of catalogs listing genetic signatures of Mtb drug-resistance.…
Oyeniyi Muhammed, Israel Olukayode Popoola, Muhammed Mubashir B Uthman, Ebenezer Obi Daniel, Taiwo Popoola, et al.
… in regions like Nigeria. In this context, the emergence of drug-resistant strains of Mycobacterium tuberculosis poses an escalating challenge. This study aimed to assess awareness of anti-TB drug resistance among TB patients in Kwara State, Nigeria. Utilizing a descriptive cross…
Venkata Giri Prasad Polu, Sreekanth Basireddy, Kota Neela Mani Kanta, Mithun Roy, Benson Wesly Buraga, et al.
The rise of pre-extensively drug-resistant (pre-XDR) and extensively drug-resistant (XDR) tuberculosis (TB) represents a serious threat to global health. This research investigates resistance patterns of Mycobacterium tuberculosis (MTB) clinical isolates to fluoroquinolones (FQs)…
Álvaro Auñón, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, et al.
…thetic joint infection (PJI), but the outcome impact of key resistance phenotypes is unclear. Methods: We retrospectively studied consecutive monomicrobial S. epidermidis PJIs treated at a tertiary hospital (2010–2024). PJI was defined according to 2018 ICM criteria. Success requ…