Showing 51–75 of 200 documents
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Thomas B Nutman, M.D.
Background: Tuberculosis (TB) is a severe disease and a major cause of death in many people worldwide. It is caused by a bacteria that enters through the lungs and can spread elsewhere in the body. People with latent TB have the bacteria that lie dormant but can become active an…
Ifedayo MO Adetifa, MD FWACP, Martin OC Ota, MD FWACP PhD
In populations with high prevalence of latent tuberculosis infection (LTBI), malnutrition (PEM) may influence incident rates of TB. PEM and specific micronutrient deficiencies compromise cell mediated immunity (CMI) and increase susceptibility to, or severity of infections. Vitam…
I. V. Kudryavtsev, Анна Старшинова, Artem Rubinstein, Anastasia Kulpina, Hong Ling, et al.
Despite advancements in modern medicine, tuberculosis continues to be one of the leading causes of death globally. Findings indicate that COVID-19 may trigger the activation of tuberculosis infection (TB), leading to its spread. Despite the development of new immunological diagno…
Navin Kumar Devaraj, Rabiatul Adawiyah Sufian, Nuzul Evana Jasmi, Ah San Leong, Rosmaliza Kamaruddin, et al.
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as the presence of Mycobacterium tuberculosis antigen without the evidence of tuberculosis infection. Approximately 5-10% of untreated LTBI would progress to clinically active tuberculosis during their lifetime or usua…
Kulkanya Chokephaibulkit, Keswadee Lapphra, Paninun Srinuchasart, Sansnee Senawong, Utane Rungpanich, et al.
…ldren younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active tuberculosis. QuantiFERON-TB Gold, T-SPOT.TB and tuberculin skin test were performed in each patient.Results: Of the 60 children, median age 3.3 years, 17 had tuberculosis an…
Yong Fang, Na Wang, Liang Tang, Xiaojun Yang, Yuan Tang, et al.
…onsuming and of low sensitivity for the diagnosis of active tuberculosis (ATB). The purpose of this study is to investigate the accuracy of CD27 - CD38 + IFN-γ + CD4 + /CD4 + for active tuberculosis (ATB) diagnosis. Methods: This prospective diagnostic accuracy study was conducte…
Lijiao Chen, Lingke Yuan, Tingting Sun, Ruiqing Liu, Qing Huang, et al.
Abstract Background Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis (MTB) and is the ninth leading cause of death worldwide. It is still difficult to distinguish active TB from latent TB ,so it is very important for individualized management and …
Muhammad Irshad, Shahzeen Irshad
…vity (83%) and 100% specificity for detecting Mycobacterium tuberculosis from fresh ulcer base biopsy samples, offering an alternative to conventional methods like acid-fast bacillus staining, TB-PCR, and histopathological examination. Given the diagnostic challenges in tuberculo…
Giovanni Battista Migliori, Ong C, Linda Petrone, Lia D’Ambrosio, Rosella Centis, et al.
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or…
Bo Su, Yong Fang, Na Wang, Liang Tang, Xiaojun Yang, et al.
…onsuming and of low sensitivity for the diagnosis of active tuberculosis (ATB). The purpose of this study is to investigate the accuracy of CD27 - CD38 + IFN-γ + CD4 + /CD4 + for active tuberculosis (ATB) diagnosis. Methods: This prospective diagnostic accuracy study was conducte…
Alison Smith, Russell R. Kempker, Liya Wassie, Kidist Bobosha, Azhar Nizam, et al.
…amines the association between diabetes mellitus and latent tuberculosis infection among a cohort of household contacts exposed to active tuberculosis in Ethiopia, focusing attention on the need for further translational research to determine the mechanisms of susceptibility to M…
Mariana S. Sousa, Inês Ladeira, Carlos Fernandes, Ana Ponte, Adélia Rodrigues, et al.
Portugal is one of the countries with the highest tuberculosis burden in the European Union, with a reporting rate in the North region registered in 2016 of 21.6 cases per 100000 inhabitants. Anti-TNF can increase up to five times the reactivation of tuberculosis in patients with…
E. M. Bogorodskaya, В. И. Литвинов
…erature review briefly describes the main aspects of latent tuberculosis infection and the place of tuberculosis infection among various variants of the course of tuberculosis. Latent tuberculosis infection is one of the main problems of phthisiology. Today we have made significa…
I. Mouslim, Chaimae Jioua, Abdelfettah Touibi, S. Ouahid, F. Nejjari, et al.
…apy between 2021 and 2024. Results The prevalence of latent tuberculosis TBL identified in patients with chronic inflammatory bowel disease candidates for anti-TNFα therapy in our study was 24.1%, detected by the Quantiferon Gold IT® test. Factors influencing the results of the t…
Y. Nakano, Kenta Yamada, Koji Suzuki, Motoko Yasutomi, Motohiro Takeuchi, et al.
Pancreatic tuberculosis (TB) is a rare form of extrapulmonary TB.1 We present a case of pancreatic TB requiring differentiation from pancreatic neoplasms. A 13-year-old boy born in the Philippines presented with fever and back pain lasting 6 days. While living in the Philippines,…
Derliyana Irwan Badarudin, Muhammad Nasrum Massi, Ahyar, Arif Santoso, Burhanuddin Bahar, et al.
…Immunosorbent Assay (ELISA). The samples in this study were tuberculosis and latent after 2 months of treatment, the samples used were 30 samples, statistic tests were normality tests with Shapiro Wilk and Independent sample tests. The results of the research that has been done, …
Christine Ho, MD, Dolly Katz, PhD, Thara Venkatappa, PhD
… is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease. The study will assess the relative performance and cost of three diagnostic test…
S Praveen Raj Dr. Anitha S Menon
…cemasks is likely to reduce the spread of <em>Mycobacterium tuberculosis (MTB)</em>. However, there is an anticipated net negative effect of COVID-19 on TB control, including an increase in the number of TB cases, death and the proportion of drug- resistant TB. Here, we present s…
M. A. Vladimirskiy, M. B. Lapenkova, A. A. Elov, В. А. Аксенова, М. А. Плеханова, et al.
…led in the study, of them 8 children suffered from pulmonary tuberculosis (TB Group) and 91 had LTBI (LTBI Group). Detection of subclinical signs of tuberculosis infection activity in LTBI Group included testing the concentration of antigen-specific induction of IFN-γ at the level …
Azadeh Jafrasteh, Abdollah Karimi, Seyedeh Mahsan Hoseini‐Alfatemi, Leila Azimi, Payam Tabarsi, et al.
…are the most important diagnostic approach to Mycobacterium tuberculosis infection diagnosis. However, they cannot discriminate between latent tuberculosis infection (LTBI) and active tuberculosis (TB). Some recent studies suggested that interleukin-2 (IL-2) response to M. tuberc…
Jeffrey M. Singh, Lamiya Balushi, Nada Mahrazi, Esklid Peterson, Olivier Koole, et al.
…ackground: Oman is a high-income, low prevalent country for tuberculosis disease. Although the rates have remained static over the last decade, the country is aiming for Tuberculosis (TB) elimination. Household contacts of pulmonary TB (PTB) patients form a high-risk group of sus…
Rosana Agus, Sjafaraenan, Yulianti Samara, Muhammad Nasrum Massi
The main challenge in the management of Tuberculosis (TB) is diagnosing quickly and accurately, especially Latent Tuberculosis Infection (LTBI). LTBI detection was carried out using the Tuberculin Skin Test (TST) and Interferon Gamma Release Assay (IGRA). In TB endemic areas, the…
Paola Dal Monte, MD
In the last 30 years, tuberculosis (TB) has re-emerged in industrialised countries as a public health, with a decrease in incidence among the resident population and an increase in the burden of immigrants. Therefore, it becomes a priority to implement an effective TB control tha…
Collin R. Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn Baranowski, Alexander G. White, et al.
…nfection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a well-characterized cynomolgus macaque model of human TB, we compared radiographic, immunologic and microbiologic characteristics of early (subclinical) reactivat…
Sanghmitra Singh, Geetu Singh, Himalaya Singh, Gajendra Vikram Singh
Introduction: Tuberculosis (TB) remains a significant global health challenge, with India bearing the highest burden. Tuberculosis Preventive Therapy (TPT) is a critical strategy to prevent latent TB infection (LTBI) from progressing to active disease, particularly among househol…