Showing 51–75 of 200 documents
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Julius Brandenburg, Jan Heyckendorf, Franziska Waldow, Nicole Zehethofer, Lara Linnemann, et al.
…'s population is infected with strains of the Mycobacterium tuberculosis complex (MTBC), the causative agents of tuberculosis (TB). In this study, we present rationally developed molecular markers for bacterial burden, which are derived from mycobacterial phospholipids. Using lip…
Benjamin WYPLOSZ, Ph
… viability test in large cohort of smear-positive pulmonary tuberculosis patients under treatment and to determine if the test could help physicians to discontinue isolation measures in hospital setting. When patients with pulmonary tuberculosis (TB) are hospitalized for diagnos…
Alina Malic, Adriana Niguleanu, Tatyana Osipov
Treatment of tuberculosis (TB) includes various therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by…
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, et al.
Abstract Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis (Mt…
Mursalim Mursalim, Syahida Djasang, Muhammad Adil Awal, Sitti Hadijah, Kusnadi Kusnadi
Mycobacterium tuberculosis is a type of bacteria causing infectious desease called tuberculosis. According to the Makassar City Health Office, total tuberculosis (TB) patients in 2019 were 5,412 with 83% cure rate. The number of TB cases had dropped to 3,250 in 2020 with 85% cure…
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
Background: Pulmonary tuberculosis is a debilitating infectious disease that affects all age groups and sadly, a leading cause of death in developing countries particularly in sub-Saharan Africa. One major challenge facing the global efforts against tuberculosis is drug-resistanc…
O.M. Shvets, О.С. Шевченко, Liliia D. TODORIKO, Olena Tovazhnyanska, Olga I. DUBYNSKA, et al.
…heral neuropathy in patients with newly diagnosed pulmonary tuberculosis during the treatment with first- and second-line antitubercular drugs, by studying the changes of plasma vitamin B1 and vitamin B12 levels. Materials and methods. The study involved 22 patients with drug-sus…
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…phic characteristics of drug-susceptible and drug-resistant Tuberculosis in Khyber Pakhtunkhwa, Pakistan. Material and Methods: A retrospective survey was conducted on data from the TB Control Program Khyber Pakhtunkhwa recorded between 1st January 2021 to 3rd June 2022. 7 sentin…
A.O. Temitayo-Oboh, Ayotunde Sherif Azees, J.O. Amin, A.R. Salam, M.M. Fasiku
Background: Surveillance of tuberculosis treatment outcomes is very crucial in evaluating successes of tuberculosis (TB) intervention programmes as well as assessing progress towards achieving the Sustainable Development Goals target of ending TB infection by 2030. The study asse…
Gustavo Amorim, James Jaworski, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Marina C. Figueiredo, et al.
…enetic polymorphisms have been associated with risk of anti-tuberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. Methods Participants were followed in Regional Prospect…
Richard Delali Agbeko Djochie, Berko Panyin Anto, Mercy Naa Aduele Opare-Addo
Abstract Background Achieving optimal rates of success in tuberculosis treatment is vital not just for the individual patient’s well-being but also for preventing the rise of drug-resistant tuberculosis strains. Unfavourable treatment outcomes pose significant challenges for heal…
A.A. Danhausa, E.E. Daniel, C.J. Shawulu, Adamu Nuhu, L. Philemon
…e WHO efforts to promote a unified global control strategy, Tuberculosis remains a leading cause of infectious mortality. In this paper, a Mathematical Model for Tuberculosis Epidemic with Passive Immunity and Drug-Sensitivity is presented. We carried out analytical studies of th…
Maïga Soumaïla, Ouédraogo Gafourou Arsène, Ali Moussa Mahaman Laouali, Ouattara Aïsseta Yasmine, Zonon Hamadé, et al.
Introduction: Tuberculosis remains a public health problem. The objective of this study was to investigate the comorbidities associated with this disease in the city of Ouagadougou. Methodology: This was a retrospective cohort study with a descriptive and analytical purpose, cond…
Т. Е. Кононова, О. И. Уразова, V. A. Serebryakova, С. П. Чумакова, O. A. Vasilyeva, et al.
…with different clinical and pathogenetic forms of pulmonary tuberculosis. Subjects and Methods. 165 pulmonary tuberculosis patients were examined. Venous blood was used for tests. Mononuclear leukocytes were isolated by centrifugation and monocytes were extracted and transformed …
I. A. Lapyreva, O. S. Ilyina, A. S. Goncharov, E. A. Grigorieva, М. А. Плеханова
…up in the complex therapy of patients with drug susceptible tuberculosis and HIV infection. Subjects and Methods. In 2020-2021, 40 patients with HIV infection and drug susceptible respiratory tuberculosis with a positive sputum test were examined in Moscow Regional Clinical TB Di…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
M. Aharmim, Mohamed Lakhal, Nezha Reguig, J.E. Bourkadi
…re but potentially fatal vascular complication of pulmonary tuberculosis and an uncommon cause of massive hemoptysis. A 27-year-old female with no significant past medical history was admitted for a seven-month history of productive cough, intermittent mild hemoptysis, fever, nig…
Ismaheel O. Lawal, Bernard Fourie, Matsontso Mathebula, Ingrid Moagi, Thabo Lengana, et al.
…96 Background: FDG PET/CT imaging at the completion of anti-tuberculosis therapy (ATT) may show residual metabolically activity (RMA) in patients considered cured at end of treatment (EOT) based on current standard of care diagnostic definitions. The significance of RMA as a risk…
Hendra Subroto, Ida Parwati, Bachti Alisjahbana, Coriejati Rita, Yuhpita Indah Efriyani, et al.
There are still limitations in the diagnosis of tuberculosis (TB), and developing monitoring tools to predict treatment outcomes for TB patients is important. Sputum collection is not only challenging but also has low sensitivity when used as a diagnostic specimen. Interferon gam…
Cicik Alfiniyah, Windarto Windarto, Nadiar Almahira Permatasari, Muhammad Farman, Nashrul Millah, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, stands as one of the most infectious diseases globally, predominantly affecting the lungs (known as pulmonary tuberculosis). It manifests in two primary forms based on bacterial drug sensitivity: drug-sensitive TB (DS-TB) a…
Edgardo A. Ferrán, Eliza Alexander, James Brown, A Gibertoni-Cruz, MCI Lipman, et al.
…rated that both Drug-sensitive (DS) and Drug-resistant (DR) tuberculosis (TB) can be treated effectively with short-course quinolone-containing combination therapy. Current WHO guidance includes using a four-month treatment with quinolones throughout for DS TB. The adverse event …
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
Background: Tuberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens …
Lauren A. Saag, Peter F. Rebeiro, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Bruno B. Andrade, et al.
…first two months of anti-TB therapy) is a predictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two mo…