Showing 51–75 of 200 documents
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Tushar Garg, Vivek Gupta, Dyuti Sen, Madhur Verma, Miranda Brouwer, et al.
…ompanied by the CHW to a designated government facility for diagnostics. Those with a confirmed TB diagnosis were put on treatment by the CHW and followed-up till treatment completion. All services were provided free of cost and patients were supported throughout the care pathway…
Mercy Corps Pakistan
…ity, cost-effectiveness, and turnaround time of the new NAT diagnostics compared to the Xpert Ultra platform. The strategy will involve both quantitative and qualitative research methods. Quantitative data will be collected and analyzed regarding the cost per test and the time ta…
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
R. Nath, Pranav Ish, Kumari Harshita, Ashish Sethi
…acillary loads, which lower the sensitivity of conventional diagnostics.[7] AI models trained on diverse datasets may help detect subtle radiological or clinical patterns, thus improving case detection in this vulnerable subgroup. Molecular diagnostics are also being transformed …
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
J Stübler, L Denkmayr, M J Studnicka, P Kaiser-Krug
Abstract Rationale Endobronchial ultrasound-guided (EBUS) TBNA is the current standard for minimally invasive sampling of mediastinal/hilar lymph nodes. However, cytological specimen may not be sufficient for diagnosis requiring preserved tissue architecture. EBUS-guided TBINCB h…
Tennis Tomo Camagu Potelwa
In the HIV/TB endemic public care setting of the Western Cape, diagnostic consideration of patients with persistent lymphadenopathy is focused towards extra- pulmonary tuberculosis (EPTB), more than other infectious or malignant causes of lymphadenopathy. We investigated patients…
Cristina Blanco‐Vázquez, Marta Alonso‐Hearn, Ramón A. Juste, María Canive, Tania Iglesias, et al.
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), responsible for important economic losses in the dairy industry. Current diagnostic methods have low sensitivities for detection of latent forms of MAP…
Joyce Mulenga, Lonia Mwape, Patricia Katowa-Mukwato
Background Tuberculosis (TB) and human immunodeficiency virus (HIV) constitute the main burden of infectious disease in resource-limited Countries6. Persons infected with HIV are particularly susceptible to tuberculosis, both from the reactivation of latent infection and from new…
Fahriye Hakan-Groen
The Dutch national uveitis guideline advises on the diagnostic work-up of uveitis patients. However, some of the included diagnostic tests as well as their value in the work-up for new uveitis patients were so far not systematically studied. \nWith the rise of novel diagnost…
Dionysius B. P. Manyakori, Andri Danika
Abstract Wrist tuberculosis (TB) is a rare manifestation of osteoarticular TB that presents substantial diagnostic challenges, particularly in TB-endemic regions. Its insidious onset and nonspecific clinical manifestations frequently lead to misdiagnosis and delayed treatment. Th…
B Bermawi, Dewi Kurniasari, Ayunda Imaniar, Nurul Hidayatih, Diana Arum Lisnawati, et al.
INTRODUCTION: Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is …
Jean de Dieu Iragena, Achilles Katamba, Anandi Martin, Moses Joloba, Willy Ssengooba
…CT Background The implementation of rapid tuberculosis (TB) diagnostics is essential for TB control. Factors influencing their uptake in Africa are unknown. We conducted a survey to collect the status and document Predisposing, Enabling, and Need (PEN) factors influencing so that…
Brooke E Nichols, Alexandra de Nooy, Naseem Cassim, Lucia Hans, Manuel Pedro da Silva, et al.
ABSTRACT To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We therefore sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to deepen …
All India Institute of Medical Sciences
The goal of this Diagnostic accuracy study is * To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and * To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical out…
Justin Onyebuchi Nwofe, Laura Madukaji, Daniel Chinenyeike Offie, Dickson Adeolu Adetoye, Emmanuel Adewale Ojo, et al.
Abstract Introduction Tuberculosis (TB) diagnosis remains the weakest link in the care cascade, particularly among people living with HIV and AIDS (PLHIV) with advanced HIV disease (AHD), who are often cannot produce quality sputum for standard tests. Urine-based assays such as D…
Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, et al.
…et Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-hu…
A. de Nooy
…agnostic care cascade. In many contexts, access to accurate diagnostics can be limited or delayed, with this contributing to onwards transmission and poorer health outcomes. Substantial investment in the research, development, and implementation of affordable, scalable, and conte…
Christoph Lange, Professor
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investig…
Xiaoting Liu, Dong XiLin, Yu Zhang, Ping Fang, Hongyang Shi, et al.
Abstract Background: Pleural effusions are caused by various reasons, whose diagnosis remains challenging in spite of various means of diagnosis. Medical thoracoscopy, greatly improves the diagnostic efficacy and gets preference for managements, especially undiagnosed pleural eff…
Lucy Mupfumi, Tapson Nyondo, Judith Mzyece, V. Kampira, Moussa Condé, et al.
…ators to reaching universal access to WHO-recommended rapid diagnostics (WRDs) in a selection of African countries. Data for 24 African countries were sourced from the WHO Global TB database to evaluate the proportion of notified people with TB tested with a WRD between 2021 and …
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
TB-Speed SAM is a multicentric, prospective diagnostic cohort study conducted in two countries with high and very high TB incidence (Uganda and Zambia). It aims at assessing several diagnostic tests that could result in the development of a score and algorithm for TB treatment de…
Hamid Dahmardeh, Alireza Teimouri, Zeynab Shayan Khah
Background: Pulmonary tuberculosis (PTB) remains a major global health concern that requires early and accurate diagnosis. Standard methods, such as sputum smear microscopy and culture, are often slow and may miss smear-negative cases. Chest computed tomography (CT) can reveal ra…
Olivier Marcy, PhD, Maryline Bonnet, PhD, Eric Wobudeya, PhD
The TB-Speed Decentralisation study aims to increase childhood Tuberculosis (TB) case detection at district hospital (DH) and Primary health Care (PHC) levels using adapted and child-friendly specimen collection methods, i.e. Nasopharyngeal Aspirate (NPA) and stool samples, sensi…
Muhammad Nusrullah, Afeera Hamid, Muhammad Rashid, Hafiz Muhammad Taha Waqas, Abdul Rauf
Fiberoptic bronchoscopy with bronchial washing is done for diagnosis of pulmonary tuberculosis among patients who cannot produce sputum spontaneously. Aim: To evaluate the diagnostic yield of Fiberoptic Bronchoscopy for detection of positive cases in cases of Smear negative pulmo…