Showing 51–75 of 87 documents
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Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, et al.
…adian Bronchiectasis and Nontuberculous Mycobacterial (NTM) Registry aims to 1) outline the clinical characteristics and natural history of bronchiectasis in Canada, 2) identify risk factors contributing to disease progression within Canadians, 3) integrate comprehensive clinical…
Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry Brown, et al.
… fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would improve searching for believable, generalizable, reproducible and accurate biomarkers. METHODS: We r…
Yuli Lily Hsieh
…ologies to enhance the quality of evidence translation from clinical trial findings into real-world healthcare decisions. Decisions on whether to adopt new healthcare technologies often rely on evidence from randomized controlled trials (RCTs). However, trial and target populatio…
Erin Boland, Halle R Amick, Leila C. Kahwati, Daniel E Jonas, Cynthia Feltner, et al.
…ing its 1996 recommendation. MEDLINE, Cochrane Library, and trial registries, searched through August 3, 2015; references from pertinent articles; and experts. Literature surveillance was conducted through May 31, 2016. English-language studies of LTBI screening, LTBI treatment w…
C.A. Celis-Preciado, Simon Leclerc, Martine Duval, Dominic O. Cliché, Pierre Larivée, et al.
…r utility in acute asthma is unclear. We speculate that the clinical and biological response to those treatments varies according to inflammometry and microbiological test results. Methods and analysis An observational longitudinal pilot study with multimodal clinical and transla…
Stefano Aliberti, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Sotgiu, Maura Spotti, et al.
…This manuscript describes the protocol of the first Italian registry of adult patients with respiratory infections caused by NTM (IRENE). Methods: IRENE is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory …
David Gisselquist
…sks for Covid-19 infection. Expedited randomized controlled trials, as done for Covid-19 vaccines, could have assessed their protection against C19 no later than end-July 2020. Methods: On 21 April 2021, I searched trial registries maintained by the US National Institutes of Medi…
Faidra Laskou, Victoria Konzett, Josef S. Smolen, Christopher J. Edwards, Daniel Aletaha, et al.
…e were searched for observational and randomized controlled trials (RCTs) with a primary endpoint of DMARD safety on conventional-synthetic, biological, and targeted-synthetic DMARDs (csDMARDs, bDMARDs, tsDMARDs respectively), as well as glucocorticoids (GC) and biosimilars, publ…
Lovely Jain, Meenakshi Malik, Kulbir Kaur, Sarita Dogra, Abhishek Purohit, et al.
…SE, Scopus, CINHAL, Web of Science, Cochrane Library, major trial registries, and grey literature. We searched for randomized controlled trials, and observational studies, comparing World Health Organization (WHO) approved treatment regimens of 12 months duration (shorter regimen…
Yu Bai, Y. Xue, Mucong Li, Mengtao Li, Chanyuan Wu
… drawing on epidemiological studies, observational cohorts, clinical trials, and international guideline documents, with emphasis on quantitative risk stratification and clinically relevant diagnostic and therapeutic considerations. Epidemiological data consistently demonstrate t…
Enya Daynes, Neil Greening, Salman Siddiqui, Sally Singh
…be recruited to a double-blind, randomised, sham-controlled trial. Both groups will follow an 8-week intervention phase using the device three times per day for 5 min at a time. This will be recorded in a self-reported diary. The device applies a flow resistive load and oscillati…
Stefan Weber, Betsy Wolf, Katharina Manten, Balamugesh Thangakunam, Barney Isaac, et al.
…). Diagnostic potential of a multi-variable model combining clinical and ultrasound findings was explored using generalized mixed methods and random forest approach. (German trial registry DRKS00026636) Findings We included 541 participants of whom 102 (19%) had TB and 1% had HIV…
Dick Menzies, MD
… will use a Bayesian adaptive Phase 2 randomized open-label trial design to test at least three experimental Tuberculosis Preventive Treatment (TPT) regimens to identify at least one regimen of ≤2 months duration that has non-inferior safety, completion, and tolerability in adult…
Joshua P. Metlay, Grant Waterer
…n, should be similarly investigated in this regard. Ongoing trials will help clarify whether immunomodulating therapies are beneficial in patients with COVID-19–related pneumonia.References1. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-…
Yingqi Liu, Huarui Shen
…al fusion [1,2]. There are still no studies to evaluate the clinical efficacy of OLIF in lumbar tuberculosis surgery. Recently, Du et al. [3] performed a retrospective comparative study to evaluate the clinical efficacy of OLIF combined with posterior percutaneous pedicle screw f…
Christoph Lange, Anca Vasiliù, Anna M. Mandalakas
…g, pretomanid, became available. Unfortunately, the phase 3 trial evaluating delamanid did not report superiority of this drug compared with a placebo in achieving treatment success,3von Groote-Bidlingmaier F Patientia R Sanchez E et al.Efficacy and safety of delamanid in combina…
Nathalie Lachenal, CCH Hewison, Catherine Berry, CD Mitnick, SM Ali Ahmed, et al.
…ected as part of a pharmacovigilance programme supporting a clinical trial (TB-PRACTECAL; N=552) and a prospective cohort (endTB; N=2,906). We present the birth outcomes as reported to investigators by participants. ETHICS The endTB and TB-PRACTECAL studies were both approved by …
Rakshit Kumar Singh, Chehak Bewtra, Praveena Kher
…ven the most effective treatment can cause vision loss, and clinical recovery is not always permanent. Ocular tuberculosis frequently results in permanent impairment, lowering patients' quality of life.
 Objective: This article reports the various known presentations of ocul…
M Tachibana, Shunji Matsuki, Akifumi Kurata, Masato Fukae, Sayaka Shinohara, et al.
…) of valemetostat in healthy Japanese participants. In this trial, 20 participants received two doses of valemetostat 200 mg, once alone and once after repeated daily doses of rifampicin 600 mg. Coadministration with rifampicin decreased the maximum plasma concentration ( C max )…
Dick Menzies, MD
The study is a pragmatic cluster randomized trial that is being conducted in 5 countries, with sites in 4 cities in Canada, Benin, Ghana, Indonesia and Vietnam. The unit of randomization is the health facility (24 health facilities randomized). The trial tests a complex intervent…
D Munce, W Elmaraachli, V Chen, A E Brunton, A Geyer, et al.
…iagnoses enrolled in the US Bronchiectasis and NTM Research Registry (BRR). Patients not receiving NTM treatment during the baseline period were excluded, with baseline defined as the 2-year period prior to enrollment. Patients were grouped by treatment regimen: clofazimine-conta…
Putera, Iwan
…g of ocular TB (OTB) by integrating immunological insights, clinical observations, and innovative diagnostic strategies. It combines findings from laboratory studies and patient registries in both Indonesia, a high TB-endemic country, and the Netherlands, a low TB-endemic country…
Mohanad Saleh, Tasneem Mustafa Almashaiekh, Rahaf Wasfi Thabaineh, Rawda Qasrawi, Ikram Aldarabee, et al.
…though it has been reported worldwide, its epidemiology and clinical characteristics in Palestine remain unclear. This study aimed to estimate the incidence, prevalence, and sociodemographic characteristics of sarcoidosis diagnosed between 2019 and 2024 in the southern West Bank …
Gavin Churchyard, MD, PhD, Bernard Landry, MPH
…as a Phase II, randomized, double-blind, placebo-controlled trial conducted at 1 site in South Africa. A total of 26 subjects were randomized 1:1 to receive 2 doses of either AERAS-402 at 3 x 10\^10 vp (N=13) or placebo (N=13) on Study Days 0 and 28. Dose-escalation to a second g…
Vanya Dhagat, MD
… tuberculosis infection. The study will be conducted at one clinical research site in India. The available live tuberculosis vaccine, Bacillus Calmette-Guérin (BCG), provides incomplete protection against pulmonary tuberculosis. For unknown reasons, a BCG revaccination or "boost…