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World Health Organization
World Health Organization
World Health Organization
Tolderlund, Knud, Bunch-Christensen, Kirsten, Waaler, Hans
World Health Organization
World Health Organization
World Health Organization
World Health Organization
Mussi-Pinhata, M. M., Goncalves, A. L., Foss, N. T.
Červenka, J., Tlučková, I.
Milstien, J. B., Gibson, J. J.
World Health Organization
Lin, H. T.
…lipid antigen for incorporation into multicomponent subunit vaccines. In this study, we utilized the enhanced stability of bicontinuous nanospheres (BCN) to efficiently encapsulate MA for in vivo delivery to MA-specific T cells, both alone and in combination with an immunodominan…
…lipid antigen for incorporation into multicomponent subunit vaccines. In this study, we utilized the enhanced stability of bicontinuous nanospheres (BCN) to efficiently encapsulate MA for in vivo delivery to MA-specific T cells, both alone and in combination with an immunodominan…
Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…prevention of COVID-19, and the latest progress of novel TB vaccines.BCG: Old tree sprouts new budsAlthough BCG vaccination can effectively protect infants and young children from M. tuberculosis infection, especially in the prevention of severe TB diseases such as disseminated t…
François Nosten, Professor
…pant will receive single or double doses of one of COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine, AstraZeneca vaccine or Janssen Ad26.COV2.S COVID-19 vaccine) in the deltoid muscle of the non-dominant arm. Study Duration approximately 1 year. The main focus of this study is…
Mark F. Cotton, Helena Rabie
…. WHO established criteria for introducing new tuberculosis vaccines in 2018, supporting efficacy of at least 50% in adults and adolescents, although acknowledging that a slightly less efficacious vaccine could be beneficial in this population. For infants, a vaccine should be ei…
Helen McShane, Dr
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Helen McShane
…tify a potential correlate of protection. Future candidate vaccines can then be assessed against their capacity to induce such an immune response. Potential risks to human subjects: The general risks to participants in this human pilot study are associated with phlebotomy, vac…
Jinxiang Xi, Xiuhua April
…irus disease 2019 (COVID-19). Up to date, approved COVID-19 vaccines and boosters are all administered intramuscularly. Interests in developing mucosal vaccination have been arising again during this pandemic for its convenience and painless characteristics.2 COVID-19 is known as…
Mangalakumari Jeyanathan, Dominik Fritz, Sam Afkhami, Emilio Aguirre, Karen Howie, et al.
Summary Background Adenoviral (Ad)-vectored vaccines are typically administered via intramuscular injection to humans, but this route of delivery is unable to induce respiratory mucosal immunity which requires respiratory mucosal route of vaccination. However, inhaled aerosol del…
Yue Wang, Weibing Wang
…, treatments, and innovative tools such as new tuberculosis vaccines are urgently needed. Although there have been rapid advances in tuberculosis vaccine clinical research over the past decade, mathematical modelling studies, which can provide a method to predict the potential fu…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
François Spertini
…t" vaccination strategies, in which two different candidate vaccines expressing antigens in common are given weeks or months apart, have generated strong and sustained cellular immune responses correlating with an M.tb protective effect in preclinical animal models. In such a "pr…