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Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Bavesh D Kana
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Srikant Kashinath Malegaonkar, Valliappan Muthu, Ashutosh N. Aggarwal, Digambar Behera, Ritesh Agarwal
… article by Velayutham and colleagues, reporting on shorter regimens for newly diagnosed pulmonary tuberculosis [1]. Shortening the duration of tuberculosis treatment is an unmet research need [2]. In this regard, the trial by Velayutham et al. is commendable. Nevertheless, it ha…
University College, London
…: The objective of the Phase 2B stage is to identify novel regimens of 16 weeks' duration with acceptable safety profile and the greatest potential, based on assessment of quantitative sputum liquid culture and treatment failure/relapse, to progress to investigation of optimal t…
Wenhong Zhang, PhD
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36\~44 weeks) i…
Soumya Swaminathan, MD MNAMS
…l trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis. Number of Sites:Four 1. Tuberculosis Research Centre, Chennai 2. Government Ge…
Aliya Moreira, Dana Hassneiah, Susan E. Beekmann, Philip M. Polgreen, Maunank Shah, et al.
…e 2020, CDC guidance has preferentially recommended shorter regimens for tuberculosis (TB) infection and since 2022, recommendations include 6-month regimens for drug-resistant (DR-TB) disease containing bedaquiline, linezolid, and pretomanid (BPaL) and a 4-month regimen for drug…
Suman Saurabh, Pankaj Bhardwaj
…ed as a key drug with its inclusion in all the standardized regimens for drug-resistant tuberculosis. Therefore, it is important to prevent the emergence of resistance to bedaquiline. Active drug safety monitoring (aDSM) should be rigorously implemented in addition to ensuring co…
Raehan Satya Deanasa, Arya Marganda Simanjuntak, Fara Syafira, Putri Mahirah Afladhanti, Anisa Hawari, et al.
… and moxifloxacin was active in ABSTRACT INTRODUCTION Newer regimens are needed and expected to have a shorter therapeutic time to increase drug adherence to completion in drug sensitive tuberculosis (DS-TB) patients.METHODS We conducted first a systematic review and meta-analysi…
Dr. Banurekha MBBS., MPH
The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial. Of the 321, there were 96% with sputum smear grading of 2+/3+ and 80% with \>2 zone involvement in the chest …
Ju Mi Lee, Jiyun Park, Sang‐Won Choi, Byung Woo Jhun, Su‐Young Kim, et al.
…se (MAC-PD) remain unsatisfactory. Thus, improved treatment regimens for MAC-PD are required. Clofazimine has recently been revisited as an effective drug against mycobacterial infection. We performed a comparison between the standard regimen and an alternative regimen (replacing…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Joseph M. Cicchese
… antibiotic treatment. Importantly, we find that changes to regimens provide greater improvements in granuloma sterilization times for these individuals. We also present a new pharmacodynamic model that incorporates the synergistic and antagonistic interactions associated with co…
Wenhong Zhang, PHD
…l to evaluate the efficacy and safety of seven 9-month oral regimens compared to a 9-month standard of care (SOC) regimen in RR-TB participants susceptible to fluoroquinolones, and a bedaquiline-containing 9-month oral regimen compared to a 20-month conventional regimen in RR-TB …
Beijing Chest Hospital
…dard of care in China has historically involved 18-20 month regimens, the World Health Organization (WHO) has recently endorsed shorter, all-oral regimens. The BLMZ regimen, composed of Bedaquiline (B), Linezolid (L), Moxifloxacin (M), and Pyrazinamide (Z), demonstrated high effi…
J van Ingen, F -Q ter Bruggen, A Lemson, W Hoefsloot
…cure in MAC-PD patients treated with clofazimine-containing regimens at a Dutch tertiary care center. Methods Single-centre retrospective cohort study of adults with macrolide-susceptible MAC-PD who initiated treatment with clofazimine as part of either a standard ethambutol-macr…
Ilangovan Ilavarasan, Vidhyanathan Ariharanathan, Chandrasekaran Sabitha Devi
…CI). Conclusion: The weekly HP regimen is superior to other regimens in reducing the incidence of TB. Additionally, the duration of the HP regimen is shorter compared to the commonly advised nine-month Isoniazid regimen. Compared with the daily dosage of Isoniazid, the weekly HP …
В. П. Гусева, Irina Vasilyeva, V. V. Testov
…dities. Therefore, developing alternative shortened therapy regimens with a favourable safety profile and proven efficacy remains an urgent task. Objective To compare the effectiveness of treatment of pulmonary TB with preserved susceptibility of M. tuberculosis to isoniazid, rif…
J. A. M. Raaijmakers, Mike Marvin Ruth, Jodie A. Schildkraut, Erik van den Hombergh, Rob E. Aarnoutse, et al.
…ls infected with M. avium ATCC 700898 were exposed to these regimens for 21 d. PK profiles were determined at d 0 and d 21. The pharmacodynamic effect was measured by determining bacterial densities at d 0, 3, 7, 14 and 21 for intra- and extracellular fractions. Emergence of macr…
Xueyi Chen, Oscar J Nino-Meza, Mona O. Sarhan, Bhavatharini Arun, Byeonghoon Jeon, et al.
…dicted tissue exposures which were used to design optimized regimens (Fig.1).Figure 1.Study design. Dynamic positron emission tomography (PET) was performed using radioanalogs of antibiotics (18F-pretomanid, 18F-sutezolid, 18F-linezolid and 76Br-bedaquiline) active against MDR st…
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…
Hélène E. Aschmann, Allan Musinguzi, Jillian L. Kadota, Catherine Namale, Juliet Kakeeto, et al.
…f offered different tuberculosis preventive treatment (TPT) regimens, and under which conditions they would accept treatment. Actionable evidence regarding preference for TPT is needed to inform policy and the development of novel TPT regimens. Methods: Adults engaged in care at …
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…
Rashmi Ratnam, Parul Jain, Ram Awadh Singh Kushwaha, Amita Jain, Urmila Singh, et al.
…the World Health Organization (WHO) recommends two all-oral regimens for rifampicin-resistant (RR), multidrug-resistant (MDR), and extensively drug-resistant (XDR) TB: a longer M/XDR-TB regimen (18–20 months) and a shorter bedaquiline-containing MDR/RR-TB regimen (9–11 months). T…
Heping Xiao, M.D
Multi-center, prospective study is performed to investigate the efficacy of new short-course regimen for retreatment pulmonary tuberculosis patients. To obtain optimized short-course regimen, decrease treatment cost and improve success rate. China is the country with the second…