Showing 51–75 of 200 documents
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Mijala Bajracharya, Sanjeev Singh, Sabin Shrestha, Usha Giri
Introduction: Multi drug resistance is a serious threat for high prevalence countries and may have some effect on low prevalence countries and it is defined as resistance to at least isoniazid and rifampicin. Drug resistance tuberculosis results from in sufficient chemotherapy an…
Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…search and development and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (1…
М.В. Ураксина, Petr Rogozhkin, Ekaterina Eremenko
…ic indicators for tuberculosis, the number of patients with drug-resistant forms of tuberculosis is increasing, which complicates and prolongs the treatment of such patients. The aim of the work is to study the drug resistance of Mycobacterium tuberculosis obtained from surgical …
Gunar Günther, Lorenzo Guglielmetti, Claude Leu, Christoph Lange, Frank van Leth, et al.
…sis control at times of emerging Mycobacterium tuberculosis drug resistance. Methods We investigated access to genotypic and phenotypic M tuberculosis drug susceptibility testing (DST), availability of anti-tuberculosis drugs and calculated cost of drugs and treatment regimens at…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-Resistant Tuberculosis (DR-TB) causes high mortality and morbidity rates globally. DR-TB and COVID-19 pandemic are posing a major risk to global public health and economic security, and are jeopardizing efforts in the control, prevention and elimination of TB globally. Mycob…
Ulan Kozhamkulov, Zhannur Abilova, Ainur Akhmetova, Saule Rakhimova, Nuray Tynyshtykbayeva, et al.
…khstan is among the countries with a high incidence rate of drug-resistant TB, especially MDR TB. This study collected 161 drug-resistant <italic>M.tuberculosis</italic> and selected 7 XDR and 42 pre-XDR isolates for whole genome sequencing (WGS). Drug susceptibility testing of <…
Guo Liang Gan, Matthew H. Nguyen, Elijah Willie, Mohammad H. Rezaie, Brian Lee, et al.
Abstract The efficacy of antibiotic drug treatments in tuberculosis (TB) is significantly threatened by the development of drug resistance. There is a need for a robust diagnostic system that can accurately predict drug resistance in patients. In recent years, researchers have be…
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…research was to find out the demographic characteristics of drug-susceptible and drug-resistant Tuberculosis in Khyber Pakhtunkhwa, Pakistan. Material and Methods: A retrospective survey was conducted on data from the TB Control Program Khyber Pakhtunkhwa recorded between 1st Jan…
Norbert Ndjeka, Nazir Ismail
Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrug-resistant tuberculosis. Both drugs have been in use in South Africa at least 10 years: bedaquiline since 2007 and clo…
Platon Eliseev, Irina Vasilyeva, Anatoly Vinokurov, E. A. Kuznetsov, Kirill Baibekov, et al.
…utations in M. tuberculosis (MTB) associated with delamanid drug resistance in patients with tuberculosis (TB) in Russia. Delamanid is important in treatment of multi- and extensively drug-resistant TB. Reports on delamanid drug resistance are increasing making it necessary to pe…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
Olivia Marsha Maritsa, Ni Made Mertaniasih, Ariani Permatasari, Tutik Kusmiati
…the world. This study aims to determine patterns of anti-TB drug resistance in drugresistant TB patients in Dr. Soetomo Academic Hospital from January 2022 to December 2023. This was a descriptive retrospective using patient medical record data in Dr. Soetomo Academic Hospital fo…
Derner, Catherine Marie
…t challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence and mechanisms of drug resistance amplification in TB remain areas of ongoing research and debate. This study investigated the consequences of suboptimal treatment on the acquisitio…
Nattakarn Preehativong
… health problem in Thailand according to the high burden of drug resistant tuberculosis. The drugs used in the treatment of drug resistant tuberculosis are classified as new drugs or drugs with new indications that need to use with precautions in closely monitoring This article w…
Sahjid Mukhida, Chanda Vyawahare
…ng are not in common people regarding various categories of drug-resistant TB (DRTB).[2] They don’t have awareness and differentiation about mono-resistant, multidrug-resistant (MDR), poly-drug-resistant (pDR), pre-extensive drug resistance (Pre-XDR), extensive drug resistance (X…
Mevlüt Karataş, Tülin Kuyucu, Tülin Sevim
…btained from TB surveillance forms, bacteriology laboratory drug resistance database and octomed patient follow-up program. Results: N=1146 (65.4%) of the cases were male and n=607 (34.6%) were female. The male/female ratio was 1.8 and the highest cases were observed in the 15-24…
Olatunde Olayanju
Background: There is widespread concern about the rise of drug-resistant TB because treatment outcomes of affected patients remain poor and treatment options are limited. After more than a forty-year gap without any breakthrough discovery, several new (bedaquiline and delamanid) …
Prabha Desikan, Aseem Rangnekar, Nikita Panwalkar, Ram Prakash Punde, Sridhar Anand
Detection and treatment of drug resistance in extrapulmonary tuberculosis (EPTB) is a major challenge worldwide. Drug resistance in EPTB has not been studied extensively. However, patients with drug-resistant EPTB have been reported to have poor outcomes[1]. Rifampicin and isonia…
Naila Samad, Ghulam Mustafa Wardak, Fakhra Batool, Hadeel Ahmed Kenoosh, Nnamdi C. Opara, et al.
Background. Pakistan is high burden drug resistant tuberculosis (DR-TB) country. For devising a treatment regimen and optimizing empirical drug therapy, the local epidemiology and drug resistance patterns are needed to be considered. Objectives. To evaluate the drug resistance pa…
Siddharth G. Chatterjee, Arvind Pandey
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Dipali Maganbhai Gavali, Binita Aring, Hiral Gadhavi, Akhlakahemad Nathamehta, Abhishek B Dave, et al.
…R-TB who had never been previously treated with second-line drugs. A prospective study was conducted in Culture and Drug susceptibility testing laboratory, Jamnagar and its associated Drug-Resistant Tuberculosis (DR-TB) centre. Materials and Methods: Baseline second-line liquid c…
Monika, Rakesh Yadav
…berculosis and the risk has worsened with the appearance of drug resistance, in particular multi drug resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Antimicrobial resistance (AMR), is one of the most dominant health hazard that has emerged in the 21st century. …
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
…challenge facing the global efforts against tuberculosis is drug-resistance, which necessitates the use of aminoglycoside-based second line drugs that are known to have ototoxic potentials. Hearing impairment can be a source of social distress, professional disability and in some…
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
…olved from conventional methods like culture and phenotypic drug-sensitivity testing (pDST) to rapid molecular assays such as line probe assays (LPA), Xpert MTB/Rif, Xpert Ultra, and Xpert MTB/XDR. While LPAs are highly sensitive and specific, they require specialized infrastruct…
V Bajiya, C R Choudhary, G Purohit, A Kuwal, A Mohanty
<b>Background:</b> Drug resistant tuberculosis is a serious public health problem in India. Due to inappropriate use, resistance to FQs has increased, which is a major threat to control TB worldwide. FQ resistance is caused by mutation in gyrA and gyrB genes of Mycobacterium tube…