Showing 26–50 of 200 documents
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Nirajan Niroula
The study of tuberculosis (TB) pathogenesis has benefitted from the use of animal models like mice, guinea pigs, rabbits, and non-human primates (NHPs). Except for NHP, most animal models have limitations mimicking different aspects of human TB. We propose that the domestic pig, …
Valentina Aksenova, Nadezda I. Klevno, А. И. Казаков, D.А. Kudlаy, T. A. Sevostyanova, et al.
…ologic drugs, GEBD) is associated with a high risk of local tuberculosis (TB) development. Objective. The aim of the study was to examine efficacy of tuberculosis services in children with high risk of developing tuberculosis associated with immunosuppressive therapy. Methods . T…
Tülin Çağatay, Zeki Kılıçaslan, Aylin Pıhtılı, Züleyha Bingöl, Merih Oray, et al.
Objective: Ocular tuberculosis is still considered to be a controversial issue in terms of both terminology and diagnostic criteria and treatment options. There is no common diagnostic/treatment algorithm even though new approaches exist.In this study, the results of the treatmen…
Joshua Rosenheim, Markos Abebe, Mulugeta Belay, Begna Tulu, Dawit Tayachew, et al.
…eviously reported detection of genomic DNA of Mycobacterium tuberculosis (Mtb) in peripheral blood mononuclear cells (PBMC) of asymptomatic adults with recent household exposure to an index case of infectious pulmonary tuberculosis (TB). It is not known whether this phenomenon in…
The continuing tension of the tuberculosis epidemic situation and the limited information on standard diagnostic methods for latent tuberculosis infection dictate the need to search for methods that allow us to assess with a high level of probability the risk of latent infection …
Анна Старшинова, Yulia Zinchenko, E. V. Istomina, Natalia Basantsova, M. V. Filatov, et al.
Early diagnosis of tuberculosis remains essential for the prevention of the disease and control of its incidence. The diagnosis of latent tuberculosis infection (LTBI) has significantly improved over the last years due to the use of new immunological tests, including the Diaskint…
Н. А. Стогова, Olga A. Panina
Aim: to study the prevalence of latent tuberculosis infection (LTI) among individuals with residual post-tuberculosis changes in the lungs and assess the effectiveness of the Diaskintest® for LTI detection. Materials and methods. We carried out a retrospective analysis of results…
Tao Ding, Y. Mei
…nts with rheumatoid arthritis (RA) are at increased risk of tuberculosis infection, including active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Treatment with immunosuppressive agents in patients with RA also increases the risk of ATB, the main reason for which …
Rukhshan Khurshid, Farwa Sijjeel, Samar Asim, Maira Mahmood, Huma Ashraf, et al.
Tuberculosis (TB) is endemic in many developing countries including Pakistan. It is a leading cause of death from a single infectious agent worldwide. Identification and early treatment of latent conditions help reduce the complications associated with TB. However, the identifica…
Mikhail V. Fursov, I. A. Dyatlov, В. Д. Потапов
Modeling of tuberculosis infection is carried out in order to clarify various aspects of the tuberculosis pathogenesis, as well as the testing of new anti-tuberculosis drugs. The characteristic of in vitro models (n = 16) for Mycobacterium tuberculosis dormant state and in vivo m…
Yu. V. Myronchuk, O. O. Pushnova, L. I. Chernyshоva, O. V. Dvizov
…monstrate the features of detection and diagnosis of latent tuberculosis infection and pulmonary tuberculosis in children from household contacts based on own clinical observation.
 Materials and methods. A clinical case of own observation of pulmonary tuberculosis and laten…
L. V. Slogotskaya, М. В. Синицын, D.А. Kudlаy
…ticle assesses existing immunological tests aimed to detect tuberculosis infection (tuberculin skin test, IGRA, skin test with a recombinant tuberculosis allergen). The latest inventions in the development of immunological tests that can differentiate latent tuberculosis infectio…
Ralph A Stidham, Rachel G Tyler
Tuberculosis (TB) remains a force health protection threat to the U.S. military, particularly in crucial populations at increased risk of exposure or re-activation. This analysis examined TB testing trends and the prevalence of latent tuberculosis infection (LTBI) among U.S. Army…
Davoud Sadeghi Gariz, Nader Mosavari
Background and Objectives: Tuberculosis (TB) is an infectious disease and about one-third of the world population are infected with latent TB infection. Active TB infection may develop in 5 to10 percent of individuals with latent infection; therefore, detection of latent infectio…
H-C Lai, K-S Cheng, Chia‐Hsuin Chang, C-L Feng, T-W Chen, et al.
…ern countries, low prevalence of IBD and high prevalence of tuberculosis infection were reported in Taiwan. Biological agents are a great advance in treating patients with IBD, but they can increase the risk of tuberculosis (TB) infection. This study was to investigate the incide…
Mohamed E. El Zowalaty, Hossam M. Ashour
Tuberculosis (TB) remains a challenge and threat to public health despite being a curable and preventable infectious disease. TB is caused by a potentially serious respiratory acid-fast bacillus Mycobacterium tuberculosis (Mtb). As one of the top ten causes of death globally, the…
Olga Bilogortseva, Ya. I. Dotsenko, Oksana Sivachenko, L. V. Arefyeva, V. V. Gorbenko, et al.
…h LTBI represent a large risk group for reactivation of the tuberculosis process at any time. The available diagnostic methods do not answer the question regarding the risk of local TB formation in them. Aim: to present a model for predicting the risk of developing localized tube…
Yong Li, Linlin Song, Ying Zhang, Zhenzhou Feng, Feng Sun, et al.
…or distinguishing healthy individuals and those with latent tuberculosis infection from patients with active tuberculosis, but their changes during the treatment process have been rarely studied, especially in the context of drug-resistant tuberculosis treatment. Methods: This st…
Jiayun Liu, Fengjuan Wang, Xiaoyan Hao
…atic diseases is a contributing factor to the occurrence of tuberculosis (TB) infection. The primary objectives of this investigation were to examine the risk factors associated with the advancement of rheumatic diseases in conjunction with latent tuberculosis infection (LTBI) le…
Jingyan Zhang, Qiangsen Zhong, Xiaochun Wang
…imely diagnosis is crucial for reducing the transmission of tuberculosis.In this study, we constructed and expressed PhoY2, a persistent infection related antigen of Mycobacterium tuberculosis and evaluated its potential as a diagnostic target through population experiments.The i…
Mufradul Islam Rafi, Fahmida Rahman, Sraboni Mazumder, Maksurat Zereen Khan, Avizit Sarker, et al.
Abstract Individuals with latent tuberculosis infection (LTBI) are possible reservoirs for active tuberculosis. Currently, TST and IGRA are used to diagnose LTBI, but neither can distinguish between active TB and LTBI. The purpose of this study was to assess serum miRNA-144-3p's …
Юлия Анатольевна Яровая, M. E. Lozovskaya, S. A. Krylova, O. P. Gurina, A. E. Blinov, et al.
Introduction. Vitamin D plays an important role in anti-tuberculosis immunity, and the reduction level of this vitamin in the body is critical. Aim . To estimate the probability of diagnosis of active tuberculosis in children with positive ATR-test and/or IGRA test results and di…
Mustafa As
The worldwide control of tuberculosis (TB) requires affordable and easy to apply test(s), which could diagnose active/latent TB and differentiate from vaccination with Mycobacterium bovis Bacillus Calmette Guerin (BCG), and exposure to environmental mycobacteria. The currently us…
Л. Н. Мотанова, M. N. Kudrya
…: to estimate the occurrence of clinical forms of childhood tuberculosis (TB) depending on BCG vaccination in regions with a high prevalence of TB. Materials and Methods . The research design is a retrospective continuous comparative study. We analyzed the data of registration fo…
Digambar Behera
…. However, the association and effect of COVID-19 vis-a-vis tuberculosis (TB) on each other is not clearly understood and experience on COVID-19 in TB patients is limited. There are many similarities and differences between the two diseases. Some limited and preliminary observati…