Showing 26–50 of 200 documents
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Annelies Van Rie, Conor J. Meehan
…ing (WGS) approach to explore the within-host Mycobacterium tuberculosis (Mtb) microevolution in response to antibiotic pressure, the impact of Mtb genetic diversity on treatment outcome, and the clinical implication of hetero-resistance in 331 patients with a single-strain Mtb i…
Digby F. Warner, Robin Wood
Tuberculosis (TB) remains an enigmatic disease. Consistently among the leading causes of annual global mortality, its impact is greatest in a limited number of high-burden countries, many of which are marked by poverty, stark internal inequalities, societal instability and, since…
First Affiliated Hospital of Zhejiang University
…and moxifloxacin for ethambutol) for treatment of pulmonary tuberculosis. The standard six-month regimen is two months of isoniazid, rifampin, ethambutol, and pyrazinamide, followed by four months of isoniazid and rifampin. The four-month regimen consists of two months of isoniaz…
Dongxia Zhu, Martin R. Bryce
…oviding insights for solid-state luminescence applications. Tuberculosis (TB) infection, caused by Mycobacterium tuberculosis, reveals tens of millions of new cases and causes millions of deaths each year. The traditional clinical treatment for TB is long-term and combined usage …
Chanjuti Sriruan, Watchara Kasinrerk, Sorasak Intorasoot, Bordin Butr-Indr, Nathiprada Netirat, et al.
Background: Mycobacterium tuberculosis is the most common causative agent of tuberculosis. It releases secretory proteins, especially the Ag85 complex, from actively growing mycobacteria, which can be detected in mycobacterial liquid culture. Ag85B is the most abundant in the Ag8…
Yiwang Chen, Howard Takiff, Qian Gao
…wn great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observatio…
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…y is to determine whether one or two four-month regimens of tuberculosis treatment are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week, with direct observation of each dose …
B. P. Pirmakhmadzoda, Z. Kh. Tilloeva, Kh. S. Sharifzoda, Olim Kabirov, K. A. Imomnazarova, et al.
The objective of the study: to determine the burden of tuberculosis with concurrent HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV stat…
Shanghai Pulmonary Hospital, Shanghai, China
…loxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized, controlled, multicenter study planned to enroll 45 rifampicin-susceptible tuberculosis patients, who will be randomized in a 1:1:1 ratio to the BZMD group (bedaquiline + p…
Rada Savic, PhD
The Tuberculosis Trials Consortium (TBTC) phase 3 treatment trial, Study 31, will investigate the efficacy and safety of daily rifapentine (1200 mg daily) with or without moxifloxacin as part of multidrug treatment regimens for drug-sensitive pulmonary TB. The proposed study (Stu…
Prince Malonda ma Ndungi, Blaise Idiamwana Kutokama, Bijou Masokolo Malamba, Dosithée Ngo-Bebe
Background Tuberculosis, the second deadliest infectious disease in the world after COVID-19, is caused by Mycobacterium tuberculosis. This bacterium most commonly affects the lungs. Economic and financial barriers can hinder access to healthcare services for the diagnosis and ma…
Jiwon Lyu, Tae Sun Shim
…tant thing for the management of drug susceptible pulmonary tuberculosis is to diagnose active pulmonary tuberculosis as soon as possible and prevent the occurrence of new patients through appropriate treatment. Therefore, it should be a priority to quickly detect tuberculosis my…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
…n (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group without tuberculosis admitted in selected health facilities in Oyo State, Nigeria. Methodology: Over the course of four mont…
Mukunda Prasad Kafle
Treatment of Mycobacterium tuberculosis infection (tuberculosis disease) involves the use of multiple antimicrobials over several months. Therapy directed against tuberculosis (anti-tubercular therapy, or ATT) consists of rifampicin and isoniazid given daily for 6 months and pyra…
S. N. Demidik, С. Б. Вольф, E. N. Alekso
Background. Tuberculosis influences female health significantly. Aim of the study: to analyze social and clinical characteristics of tuberculosis in women with different mycobacterium tuberculosis drug susceptibility residing in Grodno region and to assess the effectiveness of th…
Daniel W Fitzgerald, MD, Carl Nathan, MD, Jean William Pape, MD
…(NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment. The study is being conducted at the GHESKIO Centers in Port au Prince Haiti This is a prospective randomized two-arm 14-day, early bactericidal activity study …
Atefeh Sadeghi Shermeh, Majid Khoshmirsafa, Ali‐Akbar Delbandi, Payam Tabarsi, Esmaeil Mortaz, et al.
Introduction: Tuberculosis (TB) and especially resistant forms of it have a substantial economic burden on the community health system for diagnosis and treatment each year. Thus, investigation of this field is a priority for the world health organization (WHO). Cytokines play im…
Simone Villa, Giovanni Battista Migliori, Lia D’Ambrosio, Mario Raviǵlione
Tuberculosis is an infectious disease caused by bacteria of the Mycobacterium tuberculosis complex that are transmitted through air droplets from persons with pulmonary tuberculosis. Once exposed, a person might become infected but only 5–10% of them will, eventually, develop the…
E. S. Nikitina, O. S. Ilyina, О. Д. Баронова
…n 150 mg, pyrazinamide 375 mg) in patients with respiratory tuberculosis and preserved susceptibility of Mycobacterium tuberculosis (MTB) to anti-tuberculosis drugs. Subjects and Methods. A post-registration observational study was conducted to assess treatment effectiveness of p…
Е. Г. Чурина, А. В. Ситникова, О. И. Уразова, V. V. Novitskiy, M. R. Patysheva, et al.
… surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and sensitivity of the pathogen to anti-TB drugs. Materials and methods . 40 patients (36 men and 4 women) with pulmonary tuberculosis (TB) were examined: 18 pa…
Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, et al.
ABSTRACT Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic e…
National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis (TB) is a serious infection that can affect the lungs and other parts of the body. The usual way to treat TB is to take 4 medicines by mouth every day for 2 months, then take 2 of the same medicines for 4 more months, for a total of 6 months. The purpose of this stud…
Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
Anna Turkova, Genevieve H. Wills, Eric Wobudeya, Chishala Chabala, Megan Palmer, et al.
BACKGROUND: \nTwo thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen. \n \nMETHODS: \nWe conducted an open-label, treatment-shortening, noninferiority trial involving childr…
V. Guseva, I. А. Vаsilyevа, V. V. Testov
…is of effectiveness and safety of treatment for respiratory tuberculosis with confirmed drug susceptibility of M. tuberculosis using short-course regimens and a six-month regimen, based on the published data. Subjects and Methods. A systematic search for randomized and quasi-rand…