Showing 26–50 of 200 documents
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Anila Jaleel, Farouk Qamar Malik, Imran Ali Zaidi, Sana Hafeez, Kiran Namoos
…se which is approximately 270 per 100,000. The emergence of drug resistant MTB poses a serious threat to the ongoing efforts to control the disease epidemic. Drug resistance to the first line drugs such as Isoniazid (INH) and Rifampicin (RIF) needs to be investigated. In this res…
Christoph Lange, Anca Vasiliù, Anna M. Mandalakas
… increase in the number of individuals identified with multidrug-resistant or rifampicin-resistant tuberculosis has been observed.1WHOGlobal tuberculosis report 2022. World Health Organization, Geneva2022Google Scholar Although a large part of this increase is attributed to impro…
E. E. Lesnik, S. Ginda
…e main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective stud…
Abbas Abel Anzaku
Abstract Background: This study evaluated the prevalence of drug resistant tuberculosis infection among suspected tuberculosis patients attending Asokoro District Hospital (ADH), Abuja, Nigeria. Methods: A total of 301 AFB+/- sputum specimens from suspected TB patients were colle…
Lei Wang, Zhidong Teng, Ramziya Rifhat, Kai Wang
Tuberculosis has been prevalent in Xinjiang with severe drug resistance situation. It is unclear that which Mycobacterium tuberculosis (M.tb) infections (drug sensitive or drug resistant) most affected the tuberculosis incidence, how to identify the relative contribution of prima…
Natalie E. Nieuwenhuizen, Lei Ji
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol (EMB), followed by four months treatment with RIF and INH (2) Infection with Mtb strains resistant to RIF and INH is termed mult…
Tuelo Mogashoa, Lucy Mupfumi, Thato Iketleng, Pinkie Melamu, Nametso Kelentse, et al.
Background The emergence and transmission of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to tuberculosis control in Botswana. Early detection of drug-resistant isolates is critical to ensure optimal t…
Dennis Mujuni, Willy Ssengooba, Ivan Ibanda, Joel Kabugo, Dianah Linda Kasemire, et al.
…nt success rates stemming from the emergence of second-line drug resistance. We aimed at determining the usefulness of second-line drug (SLD) resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis treatment outcome, among…
Susanna S van Wyk, Marriott Nliwasa, James A. Seddon, Graeme Hoddinott, Lario Viljoen, et al.
ABSTRACT Background Transmission of drug-resistant tuberculosis (TB) is ongoing, and many households face catastrophic costs when a member is diagnosed and treated for drug-resistant TB. Finding individuals with drug-resistant TB and initiating treatment as early as possible is i…
Nesri Padayatchi, MBChB, PhD
…omparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines. When drug resistance is detected by molecular methods such as the Xpert MTB/RIF assay, seco…
Siddharth G. Chatterjee
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Muhammad Novran Chalik, Alif Fathurrachman, Linda Andriani, Rouly Pola Pasaribu, Sudarto, et al.
…on immunity, there are two types of pulmonary TB infection: drug-sensitive and drug-resistant. Based on ATD sensitization tests, MTb resistance types consist of TB that is monoresistant, polyresistant, multidrug resistance (MDR), pre-extensively drug resistant (Pre-XDR), extensiv…
Yiwang Chen, Howard Takiff, Qian Gao
…g (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multice…
Trương Thiên Phú, Thuy Le, Viet Tran, Tung Thanh Phan
…ground: Tuberculosis (TB) still threatens human beings when drug-resistant tuberculosis (DR-TB), such as rifampicin-resistant TB, isoniazid-resistant TB, multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB, and extensively drug-resistant TB increases continuously. …
Ngula Monde, Mildred Zulu, Mathias Tembo, Ray Handema, Musso Munyeme, et al.
… like many countries in sub-Saharan Africa is affected with drug resistant tuberculosis. However, the drug resistant tuberculosis situation over the years has not been described in various regions of the country. Consequently, this study aims to determine the drug resistant tuber…
Tarun Narang, Divya Kamat, Vishal Thakur, Mallika Lavania, Itu Singh, et al.
…dia. It is believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance as a cause for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. AIM: To study drug-resistance patterns in cases of leprosy re…
Hongkuan Yang, Yahong Cheng, Haoli Ma, Y. Li, Bei Han
Objective: To understand the epidemic status of drug-resistant Mycobacteriun tuberculosis in Xi'an in the past three years, and the impact of COVID-19 epidemic during 2020 so as to provide basic information for local multidrug-resistant tuberculosis (MDR-TB) prevention and treatm…
Keertan Dheda, MD/PhD
Resistance to anti-tuberculosis drugs is a continually growing problem. Multidrug-resistant tuberculosis (MDRTB) is resistance to at least rifampicin and isoniazid, and extensively drug-resistant TB is additional resistance to a fluoroquinolone and a second injectable line drug. …
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
…uberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens can result in…
Xiujuan Zhao, Lin Liu, Xingyong Wu, Sijing Li, Biao Liu, et al.
Abstract BackgroundThe emergence of antimicrobial resistance against mycobacterium tuberculosis has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug-resistant…
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Sunia Karam Din, et al.
…nvolves the administration of a panel of five antimicrobial drugs for the period of 6 months. The purpose of this study was to determine antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure and to determine efficacy of the second l…
P Sudha Kumari, M Siva Durga Prasad Nayak, Usha Devi, Susmita Susmita, SG Sushma
…f the World Health Organisation (WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases have been increasing in India. About half of the world’s MDR-TB cases are present in India. Aim: To assess the incidence of drug resistant TB in Prakasam district, Andhra Pradesh, India, …
Cuiyu Liu, Suping Li, Pan Baoshan, Hui Xing, Liang Bohui, et al.
Objective To understand the prevalence of drug resistance in pulmonary tuberculosis (TB) patients in Jiamusi, Heilongjiang province, and provide reliable references for the prevention and control of TB. Methods Mycobacterium tuberculosis strains isolated from 575 TB cases collect…
Alyssa Schami, M. Nurul Islam, Matthew J. Wall, Amberlee Hicks, Reagan J. Meredith, et al.
…the top infectious killers in the world. In recent decades, drug resistant (DR) strains of M.tb have emerged that make TB even more difficult to treat and pose a threat to public health. M.tb has a complex cell envelope that provides protection to the bacterium from chemotherapeu…
Bharath Kathi, Vubbara Anupama, Attili Sasi Kiran, Balaji Patamsetty, Gorthi Aruna, et al.
Background: Extensively drug-resistant tuberculosis (XDR TB) is a type of tuberculosis (TB) characterized by resistance to isoniazid and rifampicin, along with resistance to one of the fluoroquinolones and at least one of the second line injectable drugs. Bedaquiline is a diarylq…