Showing 1–15 of 15 documents
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Abdelgawad, Noha
Tuberculosis (TB) is the primary cause of death from a single infectious agent worldwide. During the coronavirus disease (COVID-19) pandemic, TB briefly fell to second place, but it has now regained its position as the top infectious killer. It is caused by Mycobacterium tubercul…
Marie Sjölin Wijk
Tuberculosis remains the leading cause of death from a single infectious agent globally, posing a significant threat to public health. This highlights the need for improved treatment strategies to enhance outcomes and limit the emergence of resistance. Optimizing therapy requires…
Aisha Alnami
Tuberculosis (TB) is a bacterial infection responsible for more than 1.5 million deaths per year. The emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) poses an urgent need for novel antituberculosis drugs. Filamentous temperature-sensitive p…
Michael L. Chen
…nosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susc…
Victor Barozi
…inst multi-drug resistant strains like multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Besides the search for new antimicrobial agents, the other avenue for addressing AMR is studying drug resistance mechanisms, especially single n…
Chiara Sepulcri
Tuberculosis (TB) is still the world’s top infectious killer and drug-resistant TB (DR-TB) poses a global health threat, being among the major contributors to the antimicrobial resistance crisis worldwide. The past years have seen unprecedented step forwards in DR-TB management, …
Timur Avkiran
Mycobacterium tuberculosis, the causative agent of Tuberculosis (TB) is estimated to cause nearly two million deaths worldwide each year. Current therapy for patients with drug-sensitive TB involves dosing with a combination of antibiotics over 6 months. The likelihood of recover…
Chiara Sepulcri
Tuberculosis (TB) is still the world’s top infectious killer and drug-resistant TB (DR-TB) poses a global health threat, being among the major contributors to the antimicrobial resistance crisis worldwide. The past years have seen unprecedented step forwards in DR-TB management, …
Salam El Achkar
Tuberculosis (TB) is the first killer infectious disease, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year …
Erick Manuel Delgado Moya
…parameters associated with TB. We proved the persistence of tuberculosis in a subpopulation showing the need to apply a control strategy. We formulated and studied an optimal control problem with the objective of reducing resistance to tuberculosis treatment. The controls are foc…
Tamara. Sneyd
BackgroundDrug resistant tuberculosis (DR-TB) is a serious public health issue both globally and nationally, with South Africa and Kwazulu-Natal, in particular, being among the regions with the highest burden of DR-TB.Detecting drug resistance and initiating patients onto the app…
Olatunde Olayanju
Background: There is widespread concern about the rise of drug-resistant TB because treatment outcomes of affected patients remain poor and treatment options are limited. After more than a forty-year gap without any breakthrough discovery, several new (bedaquiline and delamanid) …
F. Morel
Background: Tuberculosis (TB) remains one of the leading causes of death worldwide. The spread of multidrug-resistant (MDR) strains is alarming. Second-line drugs classified in WHO group A (fluoroquinolones (FQ), bedaquiline (BDQ) and linezolid) are the key drugs. Unfortunately, …
Erick Manuel Delgado Moya
…parameters associated with TB. We proved the persistence of tuberculosis in a subpopulation showing the need to apply a control strategy. We formulated and studied an optimal control problem with the objective of reducing resistance to tuberculosis treatment. The controls are foc…
Xie, Yan
Tuberculosis (TB) is the number one cause of human death from infectious disease in the world. Current treatments are challenged by the high levels of drug-resistant Mtb infection, which including rifampicin-resistant TB (RR-TB), multidrug-resistant TB (MDR-TB), and extensively d…