Showing 1–24 of 24 documents
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Darja Sadovska
Despite significant advancements in tuberculosis (TB) diagnostics, treatment, and prevention, the disease remains a major global public health challenge, with only limited reductions in incidence rates observed. In recent years, whole-genome sequencing (WGS) of Mycobacterium tube…
Darja Sadovska
Despite significant advancements in tuberculosis (TB) diagnostics, treatment, and prevention, the disease remains a major global public health challenge, with only limited reductions in incidence rates observed. In recent years, whole-genome sequencing (WGS) of Mycobacterium tube…
Amit Gupta, Aditya Anand, Dr. Md Sarfaraz Nawaz, D Haider
Introduction Intestinal tuberculosis-related bowel obstruction is notably prevalent in underdeveloped nations. This study aims to explore the factors leading to suboptimal patient outcomes and to detail the surgical treatments, clinicopathological features, and prognoses of tuber…
Chikwaiwa, Belamino K.
…rden TB treatment non-adherence and factors associated with tuberculosis adherence among active age-group patients on tuberculosis treatment at Wilkins Infectious Diseases Hospital and its catchment area. The specific objectives of this study were to assess the prevalence of TB a…
Sibongakonke Siphelele Mlambo, Nokukhanya Thembane, Ziningi Nobuhle Jaya
…: The co-epidemic of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB), Extrapulmonary Tuberculosis (EPTB) pose a major health issue in KwaZulu Natal (KZN) South Africa (SA). Despite improvements in HIV care, EPTB continues to affect immunocompromised individuals. Therefor…
Titilade Kehinde Ayandeyi Teibo
The virulence of Tuberculosis (TB) in the population makes it imperative to intensify studies on the disease caused by Mycobacterium tuberculosis. TB most frequently affects the lungs (pulmonary TB) and may also affect other organs (extra-pulmonary TB). There are few studies on T…
Melissa Davidsen Jørstad
Tuberculosis (TB) is still a major global public health concern. Of the 7 million incident TB cases recognized by the World Health Organization in 2018, 15% were extrapulmonary tuberculosis (EPTB) cases. Diagnosing EPTB remains a challenge despite continuing efforts and progress …
Seyedehsara Motamen
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It usually affects the lungs (pulmonary TB) but can also affect other parts of the body (extrapulmonary TB). According to the World Health Organisation (WHO) report in 2020, TB is one of the top ten …
V. Krishna, P Swetha, Rangu Srikanth Chandra
…is increasingly recognized as a significant risk factor for tuberculosis (TB), particularly in developing countries where both conditions are highly prevalent. The coexistence of these diseases complicates clinical outcomes and challenges TB control efforts. This study aimed to d…
Imman Kalyani Jena, Sunil Kumar Agarwalla
Background Extrapulmonary tuberculosis (EPTB) in children remains a significant health challenge with diverse clinical presentations and diagnostic difficulties. Given the diagnostic complexity and potential severity of pediatric extrapulmonary TB, particularly in high-burden reg…
Fajri Gafar
…and pharmacological approaches to optimize the treatment of tuberculosis (TB) in children and adolescents. In this thesis, we assessed the epidemiological characteristics and treatment outcomes, as well as the pharmacokinetics and safety/tolerability of first-line anti-TB drugs, …
M Sugumar
BACKGROUND: The risk of development of active TB from latent infection is 5-10% for lifetime in non-HIV patients and 10% per year or 30% over lifetime in HIV patients. Extrapulmonary TB accounts for 15-20% in non-HIV individuals but up to 50% in patients with advanced HIV infecti…
J Webster Jemin
OBJECTIVE: Rapid diagnosis of tuberculous meningitis (TBM) is crucial for prompt initiation of treatment. We are evaluating the diagnostic accuracy of modified Zeihl-Neelsen stain a newer diagnostic tool for the diagnosis of TBM, using consensus uniform research case definition c…
R Pathmini
…ulous lymphadenitis, the most common form of extrapulmonary tuberculosis constituting 15-20% of all cases of tuberculosis. Control of tuberculosis has become a global challenge due to emergence of MDR and XDR tuberculosis. Delay in the diagnosis and treatment increases the severi…
Sushil Pandey, Ashish Tirkey
Background: India has the highest incidence of tuberculosis in the globe, with twenty percent of cases. In India, tuberculous lymphadenitis is the most prevalent extrapulmonary variant of tuberculosis. The purpose of this study is to share our knowledge regarding tuberculous cerv…
Titilade Kehinde Ayandeyi Teibo
The virulence of Tuberculosis (TB) in the population makes it imperative to intensify studies on the disease caused by Mycobacterium tuberculosis. TB most frequently affects the lungs (pulmonary TB) and may also affect other organs (extra-pulmonary TB). There are few studies on T…
M. Dhivya
…l-time heminested PCR test which detects the presence of M. tuberculosis complex bacilli. By using 5molecular beacons that span the rpoBgene81-bp rifampin resistance-determining region (RRDR), the test simultaneously determines susceptibility to rifampin, which can be used as a s…
Stefan-Dan Zaharie
Tuberculosis is a devastating disease worldwide, and a major health issue, affecting millions of people. Considered primarily a pulmonary disease, TB can involve every system and organ in the human body. The most severe form of extra-pulmonary TB is neurotuberculosis - especially…
IL Manneh
Introduction: Tuberculosis (TB) remains a major global health challenge, partly driven by the limitations of current diagnostic and treatment monitoring tools, and an incomplete understanding of immune correlates of protection. Standard diagnostic tools, culture and molecular tes…
Mikashmi Kohli
…es that globally in 2021, 10.6 million people fell ill with tuberculosis (TB). Nearly 4.2 million people were either not diagnosed or not reported during 2021, and this makes TB diagnosis the biggest challenge. With the emergence of molecular rapid tests for TB, there is some hop…
Beatrice Napoli
Tuberculosis (TB) still represents one of the leading diseases globally, causing significant morbidity and mortality. Among the possible approaches to the disease, vaccination has been considered the most important measure for its prevention. Nowadays, it comprises the use of the…
Tshavhungwe, Mvuwo phophi
BACKGROUND: Tuberculosis (TB) remains the single leading infectious disease killer across the world. Infection of the central nervous system (CNS) is the most lethal form of the disease. There has been little adjustment to the standard drug regimens over several decades, but ther…
Joseph Donovan
…y modulate the intracerebral inflammatory response to <i>M. tuberculosis</i>. ONSD ultrasound may identify severity and predict death, in TBM. Persistent hyponatraemia associates with poor clinical outcomes.
Aditya Narayan Sahu, Asit Kumar Mallick, Suman Kumar Jagaty, Saswat Subhankar, Debasis Behera, et al.
Aim The study aims to establish the diagnostic accuracy of GeneXpert MTB/RIF in CSF for early diagnosis of tubercular meningitis and to compare the efficacy of CSF GeneXpert MTB/RIF with CSF culture for mycobacterium. Methodology This was a prospective, cross-sectional study cond…