Showing 1–9 of 9 documents
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Nurlilah Ab Rahman
Tuberculosis is a global disease that carries with it high health and socio-economic burdens onto populations. Millions of people come down with the active form of the disease every year but the proportion of the world population that carries the latent form of this disease is be…
Cross, Gail
Tuberculosis (TB) treatment remains prolonged despite highly effective antimicrobial regimens, reflecting persistent host-mediated inflammation and tissue damage. Host-directed therapies (HDTs) have emerged as a complementary strategy to improve treatment response by modulating m…
Nathan Hicks
Tuberculosis (TB) disease, caused by Mycobacterium tuberculosis (Mtb) infection, affects millions of people across the world annually. The best tool for controlling TB in individual patients and preventing transmission in populations is combination antibiotic therapy. Six months …
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Chabala, Chishala
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to …
Lena Faust
The COVID-19 pandemic has disrupted tuberculosis (TB) services globally. Measuring the extent of these disruptions is critical to mitigate their impact and provide valuable information for TB program improvement, particularly in settings hard-hit by both COVID-19 and TB, such as …
Tijani Sulaimon
We demonstrate not only that sensitivity and specificity by themselves offer a limited view into the performance of a test, but also that these metrics are not intrinsic to a test, but vary with disease prevalence.More generally, the contextual 'spectrum of disease' -which, in pr…
Markus Soner
Tuberculosis is a major yet preventable airborne infectious disease. From the infectious diseases caused by a single pathogen, tuberculosis has caused the most deaths in the world per year until the COVID-19 pandemic. In 2019, an estimated 10 million new TB cases emerged, and mor…