Showing 176–200 of 200 documents
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Marta Gómez Muñoz
Tuberculosis (TB) is an infectious disease caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb). During infection, Mtb is continuously exposed to stress from the host immune system. In order to adapt and survive, Mtb counts on its defence mechanisms, which are ti…
Abigail E. Schiff
…ved to contribute to the increased susceptibility to active tuberculosis (TB) seen in this population. The lung is an early site of HIV replication and HIV RNA and DNA have been detected in AMs in the initial stages of infection, even though HIV at this stage does not enter macro…
Louis R. Joslyn
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases in the world and remains a significant global health burden. Central to the immune response against Mtb are T cells, a type of adaptive immune cell that can k…
Nurul Adila Mohammed
Tuberculosis (TB) is an old, infectious disease scourge caused by \nMycobacterium tuberculosis (M.tb) that affects human. There are several laboratories \ndiagnostic methods available for TB screening such as sputum smear microscopy, \nculture and nucleic acid amplifi…
Solveig Birkedal Wiig
Tuberculosis is the leading cause of death caused by a single agent worldwide. A new and effective vaccine against this infection is therefore imperative. This study is a part of a larger project where the long-term goal is to create an effective vaccine against tuberculosis usin…
Paula H. Marjamäki
… meles) to examine the genetic basis of variation in bovine tuberculosis infection and its progression. I first estimate a genetic pedigree and characterise variation in extra-group paternity in the population (Chapter 2). Then, adopting a pedigree-based quantitative genetic appr…
Katrina Madden
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious lung disease that is among the leading causes of death worldwide. The complex nature of this disease has proven difficult to treat and significant research efforts are now evaluating the feasibility …
Jessica Gräb
The emergence and prevalence of Mycobacterium tuberculosis (Mtb) resistant strains requires the development of alternative therapeutic strategies, such as host-directed therapies (HDT), to treat tuberculosis (TB) infections. These HDT act on the host- response to a pathogen rathe…
Ivan Surya Pradipta
Objectives: Since the risk of multidrug-resistant tuberculosis (MDR-TB) may depend on the setting, we aimed to determine the associations of risk factors of MDR-TB across different regions. Methods:A systematic review and meta-analysis was performed with Pubmed and Embase databas…
Viktoria Brunner
…tive to traditional phenotypic testing, particularly for M. tuberculosis. However, discrepancies between phenotypic and genotypic results persist, limiting the clinical reliability of genomic prediction. This work investigates the sources of these discrepancies across three main …
Raymond M Moseki
…mechanisms underlying the immunopathogenesis of paradoxical tuberculosis associated immune reconstitution inflammatory syndrome (TB-IRIS). Paradoxical TB-IRIS is an aberrant immune response targeted against Mycobacterium tuberculosis or its residual antigens in patients with adva…
S Naidoo
Despite efforts to eradicate Tuberculosis (TB), Mycobacterium tuberculosis (Mtb), a causative agent for TB, can persist, and the emergence of drug resistance, emphasizes a dire need for new effective treatments and vaccine candidates. Recent understanding of TB immunology has sho…
Chabala, Chishala
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to …
Brianna Cheng
…ing (WGS) has the potential to improve the understanding of tuberculosis (TB) epidemiology. However, standardized reporting is necessary to enhance the reproducibility and interpretation of WGS results in genomic epidemiologystudies of TB to better inform public health decision-m…
Elmira Gurbanova
Latent tuberculosis infection LZD Linezolid MDR-TB Multidrug-resistant tuberculosis MFX Moxifloxacin MGIT Mycobacteria growth indicator tube MIC Minimum inhibitory concentration MODS Method and microscopic observation
Aisenstat, Maximilian J A
….: Scale-up of a Low-temperature Spray-drying Process for a Tuberculosis Vaccine Candidate using Lab-scale Equipment. International Journal of Pharmaceutics, 674, 125456, 2025. The publication outlines the scale-up process for an adjuvanted subunit tuberculosis (TB) vaccine. The …
Jalal Miah
…reasing burden of diabetes mellitus (DM) posing a threat to tuberculosis (TB) control globally. The global estimate of DM is expected to reach 592 million by 2030. In Europe, the estimated prevalence of DM is 8.5% and the rate of TB is 40 cases per 100,000 persons, with 74, 000 n…
Gangabhavani Pothuraju, Sk. Iaefath Naaz, Dr. Bushra, Syed Touseef Banu
Background: Multidrug-resistant tuberculosis (MDR-TB) remains a public health concern, particularly in resource-constrained settings. Limited data exist on the regional burden and epidemiological patterns of MDR-TB in Vikarabad district, Telangana, India. This study was conducted…
PATRICK BAGUMA, NEGESA JUSTINE KAFEERO
…ckground This study specifically assessed the prevalence of Tuberculosis among PLWHIV, the social and cultural factors, and the socio-economic factors contributing to the prevalence of Tuberculosis in HIV/AIDS in patients seeking health care in Kawaala Health Center IV in Kampala…
M. M. Shylo
…ues in children and adolescents infected with Mycobacterium tuberculosis and patients with tuberculosis (TB). Materials and methods. A comprehensive dental examination of 215 children aged 6 to 17 years was carried out, including 63 children and adolescents with TB (1st group), 9…
Ian Alfred Wrohan
Tuberculosis (TB) is the ninth leading cause of death worldwide, with an estimated 1.7 billion people currently affected by the disease. Multidrug resistant tuberculosis (MDR-TB) is not responsive to the most effective first-line drug treatments, and is a significant public healt…
Andreia Catarina Fernandes Pinto Fernandes
Tuberculosis (TB) is one of the top causes of death remaining a major public health problem worldwide. Mycobacterium tuberculosis is the agent of TB, infecting the human respiratory tract. Its remarkable pathogenicity hinges upon the ability to challenge the immune system of the …
Jonathan Fenn
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) and remains as one of the leading causes of death worldwide. Mtb encodes a limited number of ATP-binding cassette (ABC) importers for the acquisition of carbohydrates, potentially reflecting the nutrient…
Hannah Marie Carlson
… sanatorium reflected the predominant medical beliefs about tuberculosis in the early twentieth century. Over the following three decades, clinical treatment for tuberculosis advanced quickly. These changes made keeping up with current standards of treatment for sanatorium patien…
John Titus George
… control on treatment outcomes of sputum positive pulmonary tuberculosis in diabetic and non-diabetic patients. METHODOLOGY: In this prospective observational cohort study, all diabetic and non - diabetic (NDM) patients with sputum positive tuberculosis were recruited and followe…