Showing 151–175 of 200 documents
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Shelby-Sara Jones
…which has been shown to provide great potential in treating tuberculosis (TB). It is evident that Mycobacterium tuberculosis (Mtb), the causative agent for TB, is capable of developing resistance to various treatments that target the bacterium itself. Therefore, by designing ther…
Bumi Herman, Sathirakorn Pongpanich
Background: Diagnosis of Pulmonary Rifampicin Resistant Tuberculosis (RR-TB) with the Drug-Susceptibility Test (DST) is costly and time-consuming, and the GeneXpert for rapid diagnosis is not widely available in Indonesia. This study aims to develop an Artificial Neural Network m…
Viktoria Betin
Tuberculosis (TB) disease causes 1.6 million deaths annually, making it the leading infectious killer in the world. The causative agent of TB, Mycobacterium tuberculosis (Mtb), must replicate in macrophages to cause disease within the host. Simultaneous profiling of host and path…
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Christian Noel Dide-Agossou
…tment regimens for both drug-susceptible and drug-resistant tuberculosis (TB) are urgently needed. The key roadblock in TB regimen development is lack of valid surrogate pharmacodynamic markers for TB relapse. A recently-proposed assay called the ribosomal RNA (rRNA) synthesis (R…
Marambire, Edson Tawanda
Introduction: Tuberculosis (TB) remains a critical global health challenge, disproportionately affecting high-burden regions in Southern Africa. Household contacts of people with TB (PWTB) face elevated risks of Mycobacterium tuberculosis (Mtb) infection, yet gaps persist in unde…
Joseph M. Cicchese
Tuberculosis (TB) is one of the world’s deadliest infectious diseases. Caused by the pathogen Mycobacterium tuberculosis (Mtb), the standard regimen for treating TB consists of treatment with multiple antibiotics for at least six months. There are a number of complicating factors…
Yi Chu Liang
Tuberculosis (TB) remains a top 10 cause of death globally, with its causative agent Mycobacterium tuberculosis (Mtb) being the single deadliest infectious agent. The immune response is often unable to effectively fight Mtb infection as the bacteria is adept at manipulating and e…
Zonghao Lin
The bacterial pathogen Mycobacterium tuberculosis (Mtb) poses a significant health challenge, tuberculosis disease (TB), to humanity. The (glyco)lipids, from the cell wall of Mtb, exhibit immunological properties and hold potential as vaccine adjuvants. This thesis elaborates the…
Daniel J. Greenwood
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), remains the world’s deadliest infectious disease. Although treatable, effective chemotherapy requires at least six months of treatment with a minimum of four antibiotics. Novel antibiotics a…
Asma Javid
…ential components of the unique, lipid rich cell wall of M. tuberculosis. However, enzymes involved in the biosynthesis of mycolic acids remain under exploited as drug targets despite one of the early and hallmark anti-TB drug isoniazid which inhibits mycolate biosynthesis. Previ…
Seankongsuk Pattarakiat
Tuberculosis (TB) is a lethal disease considered a direct threat to human wellbeing in all regions worldwide Mycobacterium tuberculosis (Mtb) is a species of bacteria that causes almost all cases of TB in humans. Currently, multidrug therapy is a key strategy for treating TB. How…
Frida Arrey Takubetang
…e array of human infectious pathogens such as Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease. These models have served reasonably well in understanding the heterogeneity of pulmonary granulomas which are the main pathological hallmark of TB in …
Lona Gcanga
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to current antimicrobials. Non-coding RNAs are emergin…
Maxime Godfroid
Mycobacterium tuberculosis (MTB) is a slow-growing, gram-positive bacterium from the phylum Actinobacteria and is the causative agent of human tuberculosis disease. MTB is a strict host-associated pathogen thought to have infected one third of the human population. In addition, M…
Imman Kalyani Jena, Sunil Kumar Agarwalla
Background Extrapulmonary tuberculosis (EPTB) in children remains a significant health challenge with diverse clinical presentations and diagnostic difficulties. Given the diagnostic complexity and potential severity of pediatric extrapulmonary TB, particularly in high-burden reg…
Theresia Shirima Sabini
Bovine tuberculosis (bTB) is a bacterial and zoonotic disease which is transmitted through; consumption of unpasteurized milk, raw meat and inhalation of aerosols. This study used a deterministic mathematical model to assess the impact of each parameter in the transmission of bTB…
Mokgerwa Zacharia Monama
Emerging resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, continue to plague mankind and reduce the efficacies of antitubercular therapies that have been an effective defence against TB for decades. More specifically, mutati…
Ordoñez León, Kerly Gisselle
Tuberculosis (TB) is one of the most important infectious diseases worldwide. Understanding the transmission of MTB is essential to analyze and propose control strategies, and to monitor drug resistance spread. Ecuador is a middle burden country for tuberculosis with 7,200 new ca…
Beatrice Chung
Mycobacterium tuberculosis (M. tb) is the causative agent of tuberculosis (TB), a severe lung infection that causes 1.4 million deaths per year. During infection, M. tb is able to subvert host immune responses and survive within the macrophage by using its type-7 early secreted a…
Inês Alexandra Cesário e Araújo
Tuberculosis (TB) is a disease caused by a group of genetically related bacteria known as the Mycobacterium tuberculosis complex (MTBC) and causes 1.6 million deaths yearly. The TB granuloma is the hallmark cellular structure of latent TB that contains the spread of infection. Mo…
Nathan Hicks
Tuberculosis (TB) disease, caused by Mycobacterium tuberculosis (Mtb) infection, affects millions of people across the world annually. The best tool for controlling TB in individual patients and preventing transmission in populations is combination antibiotic therapy. Six months …
Souleymane Hassane Harouna
Tuberculosis (TB) is a contagious disease caused by the Mycobacterium tuberculosis complex (MTBc) posing a global health challenge, particularly with drug-resistant TB (DR-TB) detection and treatment. Indeed, despite global efforts, only about 43% of DR-TB cases are diagnosed and…
Ssv Jagadeeswara Rao Muvva
Tuberculosis infection remains a global health problem and the emergence of multidrugresistant TB (MDR-TB) adds further challenges in the battle to stop the spread of infection. Macrophages are the primary host cells to be infected with Mycobacterium tuberculosis (Mtb), and are t…
Santhuri Rambaran
Background: Tuberculosis is one of the major causes of morbidity and mortality worldwide. The COVID -19 pandemic has had a devastating impact on TB, contributing to increased incidence of both TB and drug-resistant TB. Identification of host immune biomarkers of TB risk, treatmen…