Showing 101–125 of 200 documents
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Eoghan C. W. Farmer
This study looks to monitor tuberculosis treatment response using molecular techniques. An assay for the detection and enumeration of Mycobacterium tuberculosis already existed in the form of the Mycobacterial Load Assay (MBL). This utilised reverse transcriptase quantitative pol…
Peter D. Craggs
…idoglycan have been shown to be essential for Mycobacterium tuberculosis growth. Mycobacterium tuberculosis GlmU is an essential bifunctional N-acetyltransferase, uridylyltransferase enzyme involved in the formation of uridine-diphosphate N-acetylglucosamine, which is the univers…
Prabhakar Bhushan Mishra, Rajendra Prasad Jaiswal, Bharat Bhushan
…hensive analysis, this study investigated the prevalence of tuberculosis infection (TBI) in India between 2013 and 2022. Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), 70 papers were examined using databases such …
Lintang Dian Saraswati, Lintang Dian Saraswati
This research examined how screening for tuberculosis among people with diabetes can be strengthened in Indonesia. Prior research has demonstrated that integrating tuberculosis and diabetes services at healthcare facilities improves early detection rates for tuberculosis, support…
Victor Barozi
…inst multi-drug resistant strains like multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Besides the search for new antimicrobial agents, the other avenue for addressing AMR is studying drug resistance mechanisms, especially single n…
Sibongakonke Siphelele Mlambo, Nokukhanya Thembane, Ziningi Nobuhle Jaya
…: The co-epidemic of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB), Extrapulmonary Tuberculosis (EPTB) pose a major health issue in KwaZulu Natal (KZN) South Africa (SA). Despite improvements in HIV care, EPTB continues to affect immunocompromised individuals. Therefor…
Titilade Kehinde Ayandeyi Teibo
The virulence of Tuberculosis (TB) in the population makes it imperative to intensify studies on the disease caused by Mycobacterium tuberculosis. TB most frequently affects the lungs (pulmonary TB) and may also affect other organs (extra-pulmonary TB). There are few studies on T…
Ana María García Marín
Tuberculosis (TB) is an airborne infectious disease with a high global burden that continues to be one of the top leading causes of death worldwide despite decades of global efforts to control it. The combination of social inequalities, difficulties in diagnosis, complicated trea…
Jeffrey Kawahara
Tuberculosis infects approximately one-quarter of the world’s population and is the leading cause of death by a single infectious disease, responsible for a reported 1.3 million deaths in 2017. Though Mycobacterium tuberculosis, the causative bacteria, is treatable with antibioti…
Cross, Gail
Tuberculosis (TB) treatment remains prolonged despite highly effective antimicrobial regimens, reflecting persistent host-mediated inflammation and tissue damage. Host-directed therapies (HDTs) have emerged as a complementary strategy to improve treatment response by modulating m…
Melissa Davidsen Jørstad
Tuberculosis (TB) is still a major global public health concern. Of the 7 million incident TB cases recognized by the World Health Organization in 2018, 15% were extrapulmonary tuberculosis (EPTB) cases. Diagnosing EPTB remains a challenge despite continuing efforts and progress …
G. L. M. Chappell
Mycobacterium tuberculosis is a pathogen responsible for around 10 million new TB cases and 1.4 million deaths per year, making it the primary cause of death from an infectious agent. A range of effective treatments are available, typically involving complex and lengthy protocols…
Khalil Al-Ismail
Background: To estimate the prevalence of latent Pulmonary Tuberculosis infection among healthcare workers in Communicable Disease Center (CDC) in Qatar and explore the factors associated with latent tuberculosis infection LTBI. Methods: A retrospective cohort study was carried o…
Se-Jin Kim
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of infectious disease mortality worldwide. Effective host immunity is critical by sampling intracellular microbes and activating appropriate T cell responses through multiple antigen presentation pa…
Szilvia Z. Tóth
An estimated 1.67 million people died of tuberculosis (TB) in 2016 and it is a threat to human life on a global-scale. To shorten current treatments and battle drug resistant strains it is important to discover and develop new drugs against the causative agent, Mycobacterium tube…
Chiara Sepulcri
Tuberculosis (TB) is still the world’s top infectious killer and drug-resistant TB (DR-TB) poses a global health threat, being among the major contributors to the antimicrobial resistance crisis worldwide. The past years have seen unprecedented step forwards in DR-TB management, …
Vikneswaran Mathiyazakan
Tuberculosis is the second leading cause of death caused by a single causative agent. The M. tuberculosis oxidative phosphorylation (OXPHOS) pathway terminal oxidases cyt-bcc:aa3 and cyt-bd were successfully targeted by Telacebec and ND-011992 respectively. The interest to unders…
Nurlilah Ab Rahman
Tuberculosis is a global disease that carries with it high health and socio-economic burdens onto populations. Millions of people come down with the active form of the disease every year but the proportion of the world population that carries the latent form of this disease is be…
Trisha Ghosh
…s to identify candidates that bind the enzyme Mycobacterium tuberculosis UDPGalactopyranose mutase (MtUGM). The enzyme catalyzes the reversible conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf), which is then assembled as the galactofuran layer in Myc…
Divenita Govender
Tuberculosis (TB), caused by the human adapted members of the Mycobacterium tuberculosis complex (MTBC), is a threat to global health. Understanding the regulatory network of the MTBC members may reveal novel vaccine candidates and drug targets. The small RNAs (sRNAs) have only r…
Noreafifah Semail
… in the ecological niche of human throat with Mycobacterium tuberculosis \ninfection are poorly understood. This study was aimed to investigate the composition of \nthroat microbiota in pulmonary tuberculosis patients in comparison to healthy TST \n(Tuberculin Skin Te…
Chiara Sepulcri
Tuberculosis (TB) is still the world’s top infectious killer and drug-resistant TB (DR-TB) poses a global health threat, being among the major contributors to the antimicrobial resistance crisis worldwide. The past years have seen unprecedented step forwards in DR-TB management, …
Timur Avkiran
Mycobacterium tuberculosis, the causative agent of Tuberculosis (TB) is estimated to cause nearly two million deaths worldwide each year. Current therapy for patients with drug-sensitive TB involves dosing with a combination of antibiotics over 6 months. The likelihood of recover…
Seyedehsara Motamen
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It usually affects the lungs (pulmonary TB) but can also affect other parts of the body (extrapulmonary TB). According to the World Health Organisation (WHO) report in 2020, TB is one of the top ten …
I.O. Semianiv
Pathomorphological changes in the lungs in tuberculosis are diverse and have many features. They range from the formation of granulomas and necrotic processes to the development of caverns and fibrosis, which together form a complex of destructive changes in lung tissue. Pathomor…