Showing 1–16 of 16 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
**BACKGROUND:** Drug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-r…
Majed Al-Mourgi, Anwar Shams, Majed Wasal Al-Morgi, Ziyad Al-Morgi
…lti-drug-resistant and extensively drug-resistant pulmonary tuberculosis are increasing, posing profound health concerns; therefore, surgical intervention is gaining popularity again. However, the effectiveness of surgical treatment needs to be reassessed. This study attempted to…
Salman Daneshi, Esmaeil Barkhori Mehni, Mohammad Kamali, Eshagh Barfar, Fatemeh Bagher Barahouei, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) is an increasing public health concern in Iran, with multidrug-resistant tuberculosis (MDR-TB) posing significant challenges to disease control efforts. This study examines the prevalence of DR-TB in Iran from January 2000 to …
Jenifer A Otieno, Lisa Malesi Were, Vittoria Lutje, Katie Scandrett, Yemisi Takwoingi, et al.
… as Xpert MTB/RIF Ultra, as the initial diagnostic test for tuberculosis (TB). However, the effect of these tests on key health outcomes is not well-established. **OBJECTIVES:** To assess the effects of three classes of rapid NAATs-low-complexity automated (LC-aNAATs), low-compl…
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
**BACKGROUND AND OBJECTIVES:** The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is esse…
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major public health challenge in Sub-Saharan Africa, exacerbated by the high prevalence of drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
…dren aged 0-18 years), concept (prevention and treatment of tuberculosis), and context (global settings). Studies with control groups were included, such as randomised controlled trials (RCTs), quasi-experimental studies, cohort studies, case-control studies, and cross-sectional …
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
…ltidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis (TB) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrapolated from adult studies, despite important bio…
Hanie Sakhi, Maryam Meskini, Mojgan Sheikhpour
**BACKGROUND:** Tuberculosis (TB) is one of the deadliest bacterial infectious diseases worldwide, with rising cases of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Bedaquiline (BDQ)-containing regimens have become important for the treatment of MDR/XDR…
Kabelo Gabriel Kaapu, Vukosi Treasure Makondo, Emilyn Costa Conceição, Ivy Rukasha
… to estimate the trends of BDQ resistance in drug resistant tuberculosis (DR-TB), characterize associated resistance mechanisms, and evaluate implications for treatment outcomes in South Africa.: We included primary studies reporting BDQ resistance, resistance mechanisms, minimum…
Mansour Kargarpour Kamakoli, Ehsan Zare BanadKoki, Mehran Nakhaeizadeh, Ava Behrouzi, Nasim Ebrahimifard, et al.
**BACKGROUND:** Monitoring the genetic diversity of the drug-resistant(Mtb) population contributes to gaining better insight into the bacterial dynamics and informing effective strategies to tackle the challenge of drug resistance. This meta-analysis study investigates the pooled…
Md Mahmudul Islam, Md Zahid Hasan, Md Touki Tahamid Tusar, Md Yeamin Hossain, Md Motaher Hossain, et al.
**BACKGROUND AND AIMS:** Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug-resistant tuberculosis (MDR-TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug-su…
Mamta Choudhary, Mamta, Pushpa
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) continues to present critical public health and individual challenges, especially in high-burden settings such as India. Despite advancements in diagnostics and therapeutics, individuals affected by MDR/…
Seyyed Mohammad Amin Mousavi-Sagharchi, Mina Rezghi Rami, Hanieh Hasani, Maede Mohammad Ghasemi, Maryam Farahhal, et al.
(MTB), the causative agent of tuberculosis (TB), remains a major global health challenge, exacerbated by the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Limitations in current antibiotic therapies have intensified interest in alternative antimi…
Muluneh Assefa, Mitkie Tigabie, Azanaw Amare, Getu Girmay, Alene Geteneh, et al.
**INTRODUCTION:** The growing challenge of antimicrobial resistance in Ethiopia and itsprogression towards XDR and PDR has become a critical public health concern. Therefore, thisreview determined the current state of emerging XDR and PDR bacteria, including pre-XDR and XDR-TB, t…