Showing 1–25 of 33 documents
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Cornelius Gweba, Adegboyega Omoniyi Oyefabi, Abimbola Awopeju, Regina Doro Jabaka, Leonard Ighodalo Uzairue
**INTRODUCTION:** The emergence of multidrug-resistant tuberculosis has eroded the gains made in the fight against tuberculosis. This review aims to provide current perspectives on the lineages of thecomplex (MTBC) associated with drug-resistant tuberculosis (DR-TB) in Africa. *…
Jaishriram Rathored, Tanushree Budhbaware, Sandesh Shende, Vishwanath Upadhyay
**INTRODUCTION:** In high-burden nations like India, tuberculosis (TB) continues to be a significant global public health concern. HIV infection, diabetes mellitus, and low socioeconomic status are examples of comorbid illnesses that increase susceptibility to tuberculosis (TB), …
Getu Diriba, Ayinalem Alemu, Abyot Meaza, Muluwork Getahun, Getachew Seid, et al.
**BACKGROUND:** Tuberculosis (TB) is a severe public health issue in prison inmates in Ethiopia since there is no routine screening for TB during prison admission. Also, drug-resistant tuberculosis (DR-TB) is a significant public health problem. Prisons are the most important per…
Muluwork Getahun, Getu Diriba, Michael Hailu, Amanuel Wondimu, Ayinalem Alemu
**BACKGROUND:** Mycobacterium tuberculosis lineages exhibit variability in geographic distribution, transmissibility, and disease phenotype. Ethiopia is one of the countries with the highest prevalence of tuberculosis. The aim of this study was to summarize the proportion of line…
Mengistu Abayneh, Ahmed Zeynudin, Yared Alemu, Teshome Degefa, Abdulhakim Abamecha, et al.
**BACKGROUND:** The spread of tuberculosis (TB), including strains resistant to at least rifampicin and/or isoniazid, remains a major public health problem in developing nations, yet few comprehensive and comparative data on TB have been produced. The aim of this systematic revie…
Deresse Daka, Belay Tessema, Awelani Mutshembele, Amir Alelign, Wubet Birhan, et al.
…lly transmissible. NTM infections are often misdiagnosed as tuberculosis (TB), especially in Ethiopia, where data on prevalence is scarce. This research aims to analyze NTM isolation from pulmonary samples and other specimens used in pulmonary tuberculosis (PTB) diagnosis among p…
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia
: The use of linezolid in drug-resistant tuberculosis has shown good effectiveness but has a high risk of adverse drug reactions (ADRs). Linezolid-related ADRs have been widely reported and may affect their therapeutic effect. This systematic review aimed to describe linezolid-re…
Nakwon Kwak, Joong-Yub Kim, Areum Han, Catherine Berry, Maria Beumont, et al.
…d for treating multidrug-resistant and rifampicin-resistant tuberculosis remains unclear. We conducted an individual patient data meta-analysis to determine the optimal linezolid dosing strategy. **METHODS:** We searched for randomised controlled trials and prospective cohort st…
Timothy Hudson David Culasino Carandang, Dianne Jaula Cunanan, Gail S Co, John David Pilapil, Juan Ignacio Garcia, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) infection, remains a significant public health threat. The timeliness, portability, and capacity of nanopore sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial…
Oumar Abakar Mahamed, Noussissy Sandokane Hounnoukon, Soraya Laraqui Houssaini, Imane El Faziki, Meryeme Kirat, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) is a constraining challenge for tuberculosis (TB) control worldwide. The Middle East and North African (MENA) region represents a significant part of the global MDR-TB burden. **AIM:** To estimate the pooled prevalence of…
Xinyang Hu, Zhiwei Wu, Jing Lei, Yanqin Zhu, Jingtao Gao
**BACKGROUND:** Drug-resistant tuberculosis (TB) remains a major global public health challenge. While bedaquiline (BDQ) offers improved treatment outcomes for patients with multi-drug resistant TB (MDR-TB), its widespread use has led to the emergence of BDQ resistance. **METHOD…
Ravindra Nath, Nitin Panwar, Aninda Debnath, Anirban Bhaumik, Jugal Kishore, et al.
Tuberculosis (TB) poses a significant occupational hazard for healthcare workers (HCWs) in India, a country bearing a substantial portion of the global TB burden. This systematic review and meta-analysis aims to determine the prevalence of TB among HCWs in India. Analyzing 10 stu…
Yipeng Sun, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib
… time to culture conversion in patients with drug-resistant tuberculosis (DR-TB). However, pulmonary lesion improvement based on chest imaging after BDQ treatment has not been evaluated. We aimed to evaluate pulmonary lesion improvement in patients with DR-TB following treatment …
Yihui Zhou, Hongxia Niu
Tuberculosis (TB) remains a global public health emergency, with multidrug-resistant TB (MDR-TB) and rifampicin-resistant TB (RR-TB) posing critical challenges. Conventional longer regimens are characterized by suboptimal effectiveness, high toxicity, and poor tolerability. Conse…
Taha Maatoug, Farah Seedat, Eman Elafef, Anissa Ouahchi, Ali Mtiraoui, et al.
…iddle East and North Africa (MENA) region face an increased tuberculosis (TB) risk due to socioeconomic and structural barriers. This systematic review synthesises evidence on TB burden, clinical outcomes, and epidemiological characteristics among migrants in MENA. **METHODS:** …
Leonardo Martinez, Jeffrey I Campbell, Lauren Linde, Fadila Boulahbal, Joan A Cayla, et al.
…sts that isoniazid may lead to a risk reduction of incident tuberculosis (TB) among close TB contacts of someone with multidrug-resistant TB (MDR-TB). **OBJECTIVES:** To evaluate the association between isoniazid TB preventive treatment (TPT), compared to no treatment, upon inci…
Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xiaohan Chen, Yan He, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) presents a significant global obstacle to TB control efforts, necessitating improved intervention strategies. The introduction of potent drugs, such as bedaquiline (Bdq), has led to the development of shorter treatment regimens.…
Mita Restinia, Jheng-Yan Wu, Fajri Gafar, Wen-Hsuan Hou, Chung-Yi Li
…olid-containing regimens for multidrug/rifampicin-resistant tuberculosis. Seven databases (January 2001-February 2026) were searched for randomized controlled trials comparing linezolid-containing regimens with standard of care (SOC). Pooled risk differences (RDs) and 95% confide…
Yusuf Wada, Hafeez A Afolabi, Ahmad Adebayo Irekeola, Kizito Eneye Bello, Chan Yean Yean, et al.
**BACKGROUND:** Latent tuberculosis infection (LTBI) remains a major public health challenge in Malaysia, yet prevalence estimates across population groups and settings are fragmented. This systematic review and meta-analysis aimed to synthesize available evidence and identify so…
Christina Zouganeli, Dimitra K Toubanaki, Ourania Karaoulani, Georgia Vrioni, Evdokia Karagouni, et al.
…antimicrobial resistance (AMR), particularly in relation to tuberculosis (TB). In the European Union (EU), the reallocation of healthcare resources towards managing COVID-19 led to a de-prioritization of TB surveillance and control. This shift contributed to delays in TB diagnosi…
Lutfian Lutfian, Sidik Maulana, Jonathan Hasian Haposan, Izdihar Javier Wardika, Muhammad Amir Mukminin, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) remains a major global health concern due to its high mortality and recurrence rates. Understanding the factors associated with these adverse outcomes is essential for guiding targeted interventions and strengthening TB co…
Dao Weiangkham, Adinat Umnuaypornlert, Surasak Saokaew, Neeranuch Wongcharoen, Samrerng Prommongkol, et al.
**BACKGROUND:** Pulmonary Tuberculosis (PTB) remains a pressing public health concern. Long hospital stays for PTB patients can overburden both patients and healthcare systems. **OBJECTIVE:** To identify the key factors contributing to extended length of stay in PTB patients. *…
Grethel N Hernandez, Kofi Seffah, Mustafa Abrar Zaman, Nimra Awais, Travis Satnarine, et al.
[This corrects the article DOI: 10.7759/cureus.36833.].
Amy Nel, Mary E Miller, Hanna-Andrea Rother
**BACKGROUND:** The impact of environmental health risk factors on the optimization of health in MDR-TB infected individuals, as well as on the prevention of transmission to household contacts, is not well documented. Establishing the recommendations of environmental health risk …
Ratnesh Sinha, Agus Fitriangga, Anushka Priya Sharan, Sameer Uz Zaman, I Wayan Gede Artawan Eka Putra, et al.
**BACKGROUND:** Tuberculosis (TB) is a major global public health concern, particularly in the South-East Asia Region (SEAR), which accounts for 43% of worldwide TB cases. Loss to follow-up (LTFU) during treatment poses a significant obstacle to tuberculosis management, leading t…