Showing 1–25 of 45 documents
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Md Mayin Uddin Hasan, Mohammad Injamul Hoq, Saifur R Chowdhury
**BACKGROUND:** Tuberculosis remains one of the primary infectious diseases in Bangladesh that affects both adults and children. Poor diagnostic criteria and insufficient reporting, especially of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in children, lim…
Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, et al.
…ated 1.3 million children (aged 0-14 years) became ill with tuberculosis, and 166,000 children (aged 0-15 years) died from the disease. Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that detects Mycobacterium tu…
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…n tests, such as loop-mediated isothermal amplification for tuberculosis (TB-LAMP), are among the molecular WHO-recommended rapid diagnostics and can provide results within a few hours, even in resource-limited settings. We aimed to synthesise evidence on the accuracy of these te…
Mikashmi Kohli, Leeberk Raja Inbaraj, Angela Salomon, Katie Scandrett, Alexei Korobitsyn, et al.
…sts widely used for simultaneous detection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum. To extend our previous review on extrapulmonary tuberculosis, we performed this update to inform a WHO policy update. **OBJECTIVES:** To estimate the diagnostic …
Xiaoli Liu, Chunmei Liu, Rong Yao, Bin Wan, Li Fu, et al.
…tic review of risk factors for drug-induced liver injury in tuberculosis patients. **METHODS:** Computerized searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Library databases to identify studies investigating risk factors for drug-induced liver injury…
Roméo Bujiriri Murhega, Yao Christian Hugues Dokponou, Férol Baudelaire Babatundé Gbenou, Laté Dzidoula Lawson, Raïssa Diaby, et al.
**BACKGROUND:** Spinal tuberculosis is the most common form of extra pulmonary tuberculosis. While cervical involvement, known as cervical Pott's disease, has traditionally been considered rare, its incidence is increasing. However, comprehensive data on its clinical presentation…
Yohanna Idsabella Rossi, Gabriel Bolner, Fabiana Dolovitsch de Oliveira, Jonathan Costa Dall'Acqua, Vânio Antunes do Livramento Junior, et al.
…ct of BCG revaccination with no revaccination in preventing tuberculosis (TB) disease. **METHODS:** We searched PubMed, Embase, and the Cochrane Library databases from inception to December of 2023 for studies that compared BCG revaccination with no revaccination or placebo for …
André Amate Neto, Taylor Endrigo Toscano Olivo, Patrícia Mastroianni, Mariane Nunes de Nadai, Marcela Forgerini, et al.
**BACKGROUND:** Pleural tuberculosis is one of the most frequent extrapulmonary manifestations ofinfection and is characterized by a pronounced immune-mediated response with a low bacillary burden. Host genetic factors appear to play a central role in its immunopathogenesis. **M…
Khalid Alyahyawi
Intestinal tuberculosis (ITB) is a complex form of extrapulmonary tuberculosis characterized by nonspecific gastrointestinal symptoms and substantial overlap with conditions such as Crohn's disease and gastrointestinal malignancies. These similarities frequently lead to diagnosti…
Zohreh-Al-Sadat Ghoreshi, Mohammad Ali-Hassanzadeh, Habibeh Mashayekhi-Sardoo, Hedyeh Askarpour, Nasir Arefinia
…*BACKGROUND:** Rapid and precise detection of Mycobacterium tuberculosis (MTB) is essential for effective management and control of tuberculosis. The diagnostic challenge is particularly acute for extrapulmonary TB, which accounts for approximately 15-20% of cases and often prese…
Guocan Yu, Xudong Xu, Yanqin Shen, Yuyang Ling
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a serious type of tuberculosis (TB) which can cause systemic clinical manifestations. Rapid diagnosis of EPTB for intervention is of great importance. Nanopore sequencing as a third-generation gene sequencing method is a new k…
Ika Nindya Kadariswantiningsih, Roy Novri Ramadhan, Derren David Christian Homenta Rampengan
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a significant public health issue in Indonesia, a country with a high tuberculosis burden. EPTB accounts for 15%-20% of global TB cases, with the proportion rising in populations co-infected with HIV. In Indonesia, estimates o…
Derara Girma Tufa, Leta Adugna Geleta, Hiwot Dejene Dissassa, Erean Shigign Malka, Addisu Waleligne Tadesse, et al.
…* The dual burden of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in children is leading to significant mortality. Although primary studies have reported wide ranges of mortality rates among HIV-TB co-infected children in various African countries, a comprehensive est…
Mohd Jaish Siddiqui, Abhishek Karmacharya, Xuemeng Wan, Yu Zhu, Chaomin Wan, et al.
**INTRODUCTION:** Abdominal tuberculosis (ATB) in children is an uncommon form of extrapulmonary tuberculosis that often presents with non-specific symptoms. These features frequently overlap with other abdominal conditions, increasing the risk of misdiagnosis or delay in diagnos…
Ravindra Kumar Garg, Shweta Pandey, Raza Abbas Mahdi, Sanjay Singhal
**BACKGROUND:** Tuberculosis (TB) affecting the central nervous system (CNS) can lead to a broad range of movement disorders, which are frequently overlooked in clinical settings. This review explores the various presentations, underlying mechanisms and patient outcomes related t…
Pranav Shivashankar, Praween Senanayake, Thomas Stephen Ledger, Nicholas Ngui
**BACKGROUND:** Thyroid tuberculosis abscesses (TTA) are rare manifestations of extrapulmonary tuberculosis, with the available literature consisting almost exclusively of individual case reports and small observational series. This systematic review aimed to evaluate current man…
Seetu Palo, Sarita Rawat, Debadutta Mishra, Monica Mishra
Female genital tuberculosis (FGTB) is a challenging extrapulmonary manifestation of tuberculosis, often presenting with nonspecific symptoms and a paucibacillary profile, complicating diagnosis. This systematic review and meta-analysis evaluated the diagnostic performance of vari…
Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
**BACKGROUND:** Diagnosing extrapulmonary tuberculosis (EPTB) in children is challenging due to nonspecific presentations and poor diagnostic yield from conventional microbiologic tests. Host gene expression signatures offer a non-sputum-based diagnostic alternative. This systema…
Amit Harshana, Mohit Goyal, Augustine Chako, Raman Mahajan
The dual burden of HIV and tuberculosis (TB) impacts people living with HIV (PLHIV) coinfected with TB. Although some primary studies have been reported on the burden of extrapulmonary TB (EPTB) among PLHIV in Southeast Asia (SEA), there is no systematic review or meta-analysis t…
Isabelle Munyangaju, Lucía Carratalà-Castro, Dulce Osório, Jacob Bigio, Kondwelani John Mateyo, et al.
Diagnosing tuberculosis (TB) in children is challenging due to non-specific symptoms, paucibacillary disease, and difficulty producing sputum. Chest X-rays (CXRs), though widely used, are often inaccessible in low-resource settings and involve radiation. Ultrasound (US) is a radi…
Juan Espinosa-Pereiro, Ana Aguiar, Eva Nara, Angelica Medina, Gladys Molinas, et al.
…cin could improve the treatment outcome of drug-susceptible tuberculosis (TB) without compromising the safety of patients. **METHODS:** We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin dos…
Muluneh Assefa, Mitkie Tigabie, Azanaw Amare, Mebratu Tamir, Abebaw Setegn, et al.
…*BACKGROUND:** Patients with cancer are at a higher risk of tuberculosis (TB) infection because of the immunosuppressive effect of prolonged chemotherapy. This study determined the prevalence of TB and TB-related deaths among patients with cancer from a global perspective. **MET…
Alhassane Diallo, Boubacar Djelo Diallo, Oumou Hawa Diallo, Miguel Carlos-Bolumbu, Mohamed Camara, et al.
…tality in persons living with HIV (PLHIV) being treated for tuberculosis (TB). **DESIGN:** Systematic review and meta-analysis. **DATA SOURCES:** PubMed, CENTRAL and EMBASE through 31 December 2023 STUDY SELECTION: Randomised placebo-controlled trials (RCTs) with published Kapl…
Louise Preston, Alexander Thompson, Susan Baxter, Duncan Chambers, Paul Collini, et al.
**BACKGROUND:** Delays in diagnosing and treating tuberculosis (TB) have significant implications. We undertook a rapid review to explore factors associated with delays at all stages of the diagnostic and treatment pathways in low-burden settings. **METHODS:** We searched databa…
Lynn Moshi, Hafidha Mhando Bakari, Jackline Vicent Mbishi, Zuhura Mbwana Ally, Mariam Salim Mbwana, et al.
…bacteria count and high likelihood of having extrapulmonary tuberculosis (TB) among patients with advanced human immunodeficiency virus (HIV) disease, the World Health Organization (WHO) recommended the use of urine lateral flow urine lipoarabinomannan (LF-LAM) or sputum-Xpert to…