Showing 1–24 of 24 documents
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Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
… and compare the effectiveness of different DR-TB treatment regimens and to assess their safety profiles based on the frequency of adverse events and drug-specific reactions. **METHODS:** We systematically searched PubMed, Web of Science, and Embase for relevant studies publishe…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…dies that reported AE data for bedaquiline-pretomanid-based regimens. In total, 14 studies from various countries were included in the analysis, comprising seven clinical trials, six implementation studies and one pharmacovigilance study. AE detection methods differed between cli…
Beatriz Bernava Sarinho, Inajara Rotta, Tácio de Mendonça Lima, Brígida Dias Fernandes, Patricia Melo Aguiar, et al.
…uating the efficacy, effectiveness, and safety of different regimens. Thus, this protocol outlines the approach for systematically reviewing and synthesizing the existing literature regarding the efficacy, effectiveness, and safety of different regimens for histoplasmosis and tub…
Yang Li, Ammar Saad, Zhen Feng, Shijia Ge, Lingyun Song, et al.
…remain poorly defined, and there is no consensus on optimal regimens, duration, or outcomes. **METHODS AND ANALYSIS:** We will conduct a systematic review of observational and interventional studies reporting anti-TB treatment in patients with asymptomatic TB. Databases includin…
Ashutosh N Aggarwal, Ritesh Agarwal, Sahajal Dhooria, Perumal K Bhavani, Kuruswamy T Prasad, et al.
Standard rifampicin doses used to treat pulmonary tuberculosis lie at the lower end of drug exposure-response curve. We evaluated if higher daily rifampicin doses result in greater efficacy or harm. We searched literature databases for randomized controlled trials comparing effic…
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk fac…
Emma C Carter, Victoria Simpson, Tilly Fox, Andrea M Collins, Stephen B Gordon, et al.
**OBJECTIVES:** This systematic review aims to synthesize the best available evidence on antimycobacterial management of Bacille Calmette-Guérin (BCG) infection in hosts without significant immunocompromise. **METHODS:** We performed a systematic review searching Medline, S…
Alice Bai, Hari Dandapani, Amrita Dosanjh
…, with a median treatment duration of 30 weeks. Common regimens included combined ethambutol with rifampin (n=9) or clarithromycin (n=6), and clarithromycin with amikacin (n=6). Most patients started on therapy for tuberculosis before switching treatment courses after NTM di…
Omri A Arbiv, Thomas Holmes, Marie JeongMin Kim, Marie Yan, Kamila Romanowski, et al.
…hat only 2 included studies were blinded. **CONCLUSIONS:** Regimens that used TDR were associated with an increase in SevAEs, raising concerns regarding safety of TDR regimens.
Svetlana Degtyareva, Yohhei Hamada, Rebecca F Baggaley, Nasser Hassan, Santino Capocci, et al.
…ing, immunological testing, treatment start and completion. Regimens lasting <6 months had higher completion rates (88.4%) than those lasting 6-9 months (74.4%) or >9 months (61.6%). **CONCLUSIONS:** Our analysis highlights substantial loss to follow-up at m…
Bhavani Perumal Kannabiran, Jayanthi Arthanari, Adhin Bhaskar, Mukesh Kumar Sathya Narayanan, Leeberk Raja Inbaraj
Background & objectives Evidence suggests that higher doses of rifampicin aid in faster culture conversion, but its effects on unfavourable outcomes are unclear. We aimed to synthesise evidence on the efficacy and safety of high-dose rifampicin (>15 mg/kg) containing anti-tubercu…
Maria-Angelica B Lerma, Ayla Niel L Castillo, Gelza Mae A Zabat
…nimal, but the studies significantly differed in the dosing regimens of the intervention, populations included, and attrition rates. The RoB was also low, but there were concerns due to high attrition rates, lack of blinding, and the addition of unplanned post-hoc analysis. The b…
Gehang Ju, Xin Liu, Meng Gu, Lulu Chen, Xintong Wang, et al.
…fampicin. Extracted data included basic information, dosing regimens, sampling strategies, model parameters, and covariate details. Non-English studies, non-parametric models, and duplicates were excluded. The repository was built using R package mrgsolve, and a Shiny application…
Warinmad Kedthongma, Sopon Usaprom, Wuttiphong Phakdeekul
…trol must integrate socioeconomic support alongside medical regimens to achieve meaningful outcomes.
Maria Magdalene Namaganda, Joyce Nakatumba Nabende, David Patrick Kateete, Charles Batte, Gerald Mboowa
Despite widespread rollout of dolutegravir-based (DTG) antiretroviral therapy (ART) in East Africa, viral non-suppression, advanced HIV disease (AHD), and multimorbidity persist, reflecting gaps in service response rather than regimen potency alone. In Uganda's The AIDS Support O…
Michael Prodanuk, Sarah L Silverberg, Pierre-Philippe Piché-Renaud, Daniel S Farrar, Jessie Cunningham, et al.
…ne were at high risk of bias. **CONCLUSIONS:** Higher-dose regimens in children were associated with increased AEs, raising caution for further dose increases and necessitating additional study of treatment tolerability. These findings are limited by publication bias in observat…
Hui Ming, Biao Fu, Xiaogang Chen, Wenbing Hu, Hui Yu
…th a significantly increased risk of TB compared to non-ICI regimens. Importantly, patients with a history of prior TB were found to be at significantly higher risk. This highlights the critical need for enhanced TB screening and vigilant monitoring, especially in this vulnerable…
Pablo Troop, Brenna Keam, Caroline Mullen, Julius Nyerere Odhiambo
**INTRODUCTION:** Tuberculosis (TB) is a notable public health issue in sub-Saharan Africa (SSA), disproportionately affecting vulnerable populations such as nomads. Their migratory lifestyles limit consistent access to TB diagnostic and treatment services, leading to delays in d…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
**BACKGROUND:** Treatment-related adverse events are one of the leading barriers to tuberculosis treatment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifam…
Xianni Wei, Ruina Cai, Xiaohong Wu, Yonglong Su, Siheng Lian, et al.
…stic criteria (ALT > 3ULN vs. >5ULN), anti-TB regimens (3-drug vs. 4-drug), HCV definition (antibody vs. RNA positivity), and study design (prospective vs. retrospective). **RESULTS:** Thirteen studies comprising a total of 3,174 patients met the inclusion criteria…
Omar Oliveira Meira, Luiz Gustavo Ribeiro Silva, Raquel Fonseca Sales, Renata Maria Colodette, Lucas Borges Gomes Ferreira Pinto, et al.
**INTRODUCTION:** Tuberculosis, although curable, presents challenges related to treatment adherence, which compromises treatment effectiveness. Individual, social and structural barriers interfere with patients' ability to properly follow the therapeutic regimen, thereby impacti…
Vishal Kumar, Sitanshu Barik, Shivji Prajapati, Lakshmana S Das, Vikash Raj
Total hip replacement (THR) in the tuberculous (TB) hip joint can be done in the same sitting or in a staged manner. The study aimed to analyse evidence within the current literature on single-stage THR in active TB hip in terms of duration and regimen of anti-tubercular treatmen…
Ramesh Kumar, Abhishek Kumar, Sudhir Kumar
… a heavy disease burden. Although current anti-TB treatment regimens demonstrate high efficacy, the hepatotoxic potential of first-line anti-TB drugs (ATDs) - particularly isoniazid, rifampicin, and pyrazinamide-poses a considerable risk, as these agents are associated with a sig…
Johnessa Cung, Patihul Husni, Kyung Taek Oh
…mortality worldwide, hampered by prolonged, toxic treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evaluates recent advancement in actively targeted nanoparticle (…