Showing 1–25 of 25 documents
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Matthew Willis, Joelle Van de Wetering, Heynes Brown, Ewelina Julia Barnowska, Sophie Cw Stuetzle, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) is a significant public health concern in India, contributing to 28% of the global pediatric TB burden. Despite its impact on child health, strategies to control TB have inadequately addressed pediatric cases, resulting in suboptimal ma…
Tom Liba, Amit Olami, Michael Brant, Alon Gorenshtein, Adir Sommer, et al.
Pediatric uveitis is a leading cause of visual impairment, often resulting in severe complications without timely and appropriate intervention. Its etiology varies geographically, necessitating a comprehensive epidemiological assessment. To identify prevalent causes of pediatric …
Vega Pangaribuan, Muhammad Arifin Parenrengi, Wihasto Suryaningtyas
…e literature on the clinical presentation and management of pediatric cervical spine tuberculosis (CST) and evaluate the outcomes of conservative or surgical treatment based on anatomical location (craniovertebral junction [CVJ], subaxial, and cervicothoracic junction). **METHOD…
Walter Fagundes, Aisha R Ahmed, Yasmin P Silva, Paweł Łajczak, Helvécio N Feitosa Filho, et al.
…loperitoneal shunt (VPS). However, its efficacy in treating pediatric tuberculous meningitis-related hydrocephalus (TBMH) remains uncertain. The authors' review aimed to evaluate the safety and effectiveness of ETV compared to VPS. **METHODS:** The authors searched PubMed, Embas…
Agata Gierlotka, Ryszard Sordyl, Ireneusz Bielecki, Marek Mandera
…te the management options for pituitary tuberculosis in the pediatric population. **METHODS:** The study was conducted based on a comprehensive literature review using the PubMed, Cochrane Library, and ScienceDirect electronic databases. The following keywords were used: pituita…
Michael Prodanuk, Sarah L Silverberg, Pierre-Philippe Piché-Renaud, Daniel S Farrar, Jessie Cunningham, et al.
**BACKGROUND:** In 2010, the World Health Organization (WHO) increased the recommended doses of first-line tuberculosis (TB) drugs for children. In this systematic review, we aimed to determine the proportion of children who developed adverse events (AEs) on first-line TB treatme…
Md Mayin Uddin Hasan, Mohammad Injamul Hoq, Saifur R Chowdhury
…im to estimate the pooled proportions of PTB and EPTB among pediatric and adult diagnosed tuberculosis cases in Bangladesh, and to summarize the associated factors. **METHODS:** We searched PubMed, Scopus, Cochrane Library, and BanglaJOL to retrieve articles published between Ja…
Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
…systematic review evaluates their diagnostic performance in pediatric EPTB. **METHODS:** We systematically reviewed host-based gene expression diagnostics for pediatric EPTB. PubMed, Embase and Cochrane Library (January 1965-May 2025) were searched for studies in children (0-18 …
Vinod Raj, Shilpa Sharma
… A PubMed search was done on 27th March 2025 with keywords "pediatric abdominal tuberculosis", using the filter of last 10 years. The articles were screened for relevance and the data were compiled on gender, age, presenting complaints, diagnosing criteria, associated pathol…
Mohd Jaish Siddiqui, Abhishek Karmacharya, Xuemeng Wan, Yu Zhu, Chaomin Wan, et al.
…dies published between 1900 and 2024. Eligible studies were pediatric case series that included confirmed ATB cases and provided information on initial misdiagnosis or diagnostic delays. Patients who were misdiagnosed or delayed in diagnosis were categorized under the "misdiagnos…
Alice Bai, Hari Dandapani, Amrita Dosanjh
…acteria (NTM) infection and disease is increasing globally. Pediatric studies on treatment of pulmonary NTM disease in immunocompetent infants are limited, and adult guidelines lack details regarding age-specific management strategies. This systematic review analyzes pharmaceutic…
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
…wer, all-oral bedaquiline- and delamanid-based regimens for pediatric MDR/XDR-TB are effective and generally well tolerated, though the full safety profile remains incompletely characterized. In pediatric MDR/XDR-TB, where studies are rare, our findings provide the best available…
Gehang Ju, Xin Liu, Meng Gu, Lulu Chen, Xintong Wang, et al.
…uded in the rifampicin model repository: 23 on adults, 5 on pediatrics, 1 on both populations, and 1 on pregnant women. Most rifampicin popPK models were one-compartment linear elimination models, with transit compartment or lagged absorption models improving drug absorption fitt…
Tae Kyu Chung, Eunsol Yang, Maureen Shin, Belen P Solans, Xujia Zhou, et al.
… **CONCLUSION:** Our IPDMA supports the revision of current pediatric EMB dosing guidelines for the treatment of tuberculosis. Our findings aim to ensure adequate drug exposure across all pediatric weight bands, while also accounting for toxicity and challenges related to formula…
Liai Peng, Yiqing Zhou, Min Wang, Zhipeng Zu, Qian Wu, et al.
Tuberculosis preventive treatment (TPT) is essential for pediatric tuberculosis control in children and adolescents. Evidence indicates most attrition occurs prior to TPT initiation rather than from post-initiation nonadherence. This study systematically evaluated TPT acceptance …
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala, Mercy Takuwa, et al.
…n countries, HIV-affected populations, social determinants, pediatric TB, and extrapulmonary disease. **CONCLUSIONS:** Machine learning models for predicting TB treatment failure show promising discrimination but are not yet ready for routine clinical implementation. Performance…
Shyamkumar Sriram, Tareq Abualfaraj, Manal Ali Alsharif, Marwa Zalat, Saad Madani Alawfi, et al.
…er SN and a higher SP relative to IGRA. However, within the pediatric population, TST showed higher SN and lower SP when compared to IGRA. Furthermore, TST also showed a lower SN and a higher SP within hemodialysis and organ transplant patients than IGRA.Our diagnostic test meta-…
Mark Kosenko, Lilit Davtian, Ekaterina Iakovleva, Mukhammad Ashurov, Dmitrii Podgalo, et al.
… **CONCLUSIONS:** Shorter rifamycin-containing regimens for pediatric TBI probably increase treatment completion and have similar safety outcomes, with no important difference in development of TB disease compared with the standard regimen. These findings support current guidelin…
Eman Farouq Badran, Abdullah Rayyan, Mira Al Jaberi, Muayyed Azzam, Raghad Ramadan, et al.
…more, two studies addressed the prevalence of meningitis in pediatric patients. In adult patients, of 192 patients known to have meningitis, a causative agent was identified in only 86 cases, with 83 (49%) classified as aseptic meningitis. **CONCLUSION:** The review addressed th…
Muhammad Abubaker Tobaiqi, Musleh Naser Alshamrani, Shyamkumar Sriram, Ahmad Bakur Mahmoud, Hammad Ali Fadlalmola, et al.
…I.G.R.A. consistently outperformed T.S.T. in both adult and pediatric populations. Among immunocompromised individuals, T.S.T. had low SN (23%) but high SP (91.2%), whereas I.G.R.A. had higher SN (65.6%) but lower SP (81.9%). Immunocompetent subjects showed that T.S.T. had SN of …
Lucía Carratalà-Castro, Shilzia Munguambe, Belén Saavedra-Cervera, Petra de Haas, Alexander Kay, et al.
… by the EU via Stool4TB Project and the European Society of Pediatric Infectious Diseases.
Jad Khaled Alsmadi, Mohammad Nebih Nofal, Sulieman Alriyalat, Ali Jad Yousef
…comparisons and perioperative outcomes. Exclusions included pediatric cohorts and studies conflating converted LN cases with ON groups. **RESULTS:** From 16 identified studies, 13 met the inclusion criteria, encompassing 868 patients undergoing nephrectomy for IRCs. Of these, 39…
Hanhan Wu, Yazhen Lang, Luqing Jin, Yanqin Shen, Weiyan Pu, et al.
**BACKGROUND:** Pulmonary tuberculosis (PTB) in childhood can result in persistent lung function impairment in adults, but data among children remain limited. This systematic review and meta-analysis aimed to summarize and update current evidence on pulmonary function outcomes af…
Fassikaw Kebede Bizuneh, Tsehay Kebede Bizuneh, Getaye Tizazu Biwota, Biruk Beletew Abate, Tilahun Gizaw Ayenew
**BACKGROUND:** Despite the effectiveness of antiretroviral treatment (ART) in reducing morbidity and mortality, children and adolescents with co-infections face an elevated risk of death due to their young age and compromised immune systems. While risk factors for tuberculosis (…
Isabelle Munyangaju, Lucía Carratalà-Castro, Dulce Osório, Jacob Bigio, Kondwelani John Mateyo, et al.
Diagnosing tuberculosis (TB) in children is challenging due to non-specific symptoms, paucibacillary disease, and difficulty producing sputum. Chest X-rays (CXRs), though widely used, are often inaccessible in low-resource settings and involve radiation. Ultrasound (US) is a radi…