Showing 1–15 of 15 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
**BACKGROUND:** Drug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-r…
Kabelo Gabriel Kaapu, Vukosi Treasure Makondo, Emilyn Costa Conceição, Ivy Rukasha
: Bedaquiline (BDQ) resistance poses a serious threat to its long-term efficacy, particularly in high-burden settings like South Africa, where data remain scattered and largely non-synthesized.: This study aimed to estimate the trends of BDQ resistance in drug resistant tuberculo…
Mansour Kargarpour Kamakoli, Ehsan Zare BanadKoki, Mehran Nakhaeizadeh, Ava Behrouzi, Nasim Ebrahimifard, et al.
**BACKGROUND:** Monitoring the genetic diversity of the drug-resistant(Mtb) population contributes to gaining better insight into the bacterial dynamics and informing effective strategies to tackle the challenge of drug resistance. This meta-analysis study investigates the pooled…
Muluneh Assefa, Mitkie Tigabie, Azanaw Amare, Getu Girmay, Alene Geteneh, et al.
**INTRODUCTION:** The growing challenge of antimicrobial resistance in Ethiopia and itsprogression towards XDR and PDR has become a critical public health concern. Therefore, thisreview determined the current state of emerging XDR and PDR bacteria, including pre-XDR and XDR-TB, t…
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
**BACKGROUND:** Children and adolescents with multidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis (TB) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrap…
Salman Daneshi, Esmaeil Barkhori Mehni, Mohammad Kamali, Eshagh Barfar, Fatemeh Bagher Barahouei, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) is an increasing public health concern in Iran, with multidrug-resistant tuberculosis (MDR-TB) posing significant challenges to disease control efforts. This study examines the prevalence of DR-TB in Iran from January 2000 to …
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
…n Sub-Saharan Africa, exacerbated by the high prevalence of drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for DR-TB, including multidrug-resistant TB (MDR-TB) and extensively DR-TB (XDR-…
Md Mahmudul Islam, Md Zahid Hasan, Md Touki Tahamid Tusar, Md Yeamin Hossain, Md Motaher Hossain, et al.
…reatment progress is increasingly threatened by rising multidrug-resistant tuberculosis (MDR-TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug-susceptible and drug-resistant() strains. However, data on its resistance mechanisms, dru…
Majed Al-Mourgi, Anwar Shams, Majed Wasal Al-Morgi, Ziyad Al-Morgi
**BACKGROUND:** The incidence and prevalence of multi-drug-resistant and extensively drug-resistant pulmonary tuberculosis are increasing, posing profound health concerns; therefore, surgical intervention is gaining popularity again. However, the effectiveness of surgical treatme…
Hanie Sakhi, Maryam Meskini, Mojgan Sheikhpour
…al infectious diseases worldwide, with rising cases of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Bedaquiline (BDQ)-containing regimens have become important for the treatment of MDR/XDR-TB, and resistance to BDQ is increasing. Understanding genetic m…
Mamta Choudhary, Mamta, Pushpa
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) continues to present critical public health and individual challenges, especially in high-burden settings such as India. Despite advancements in diagnostics and therapeutics, individuals affected by MDR/…
Seyyed Mohammad Amin Mousavi-Sagharchi, Mina Rezghi Rami, Hanieh Hasani, Maede Mohammad Ghasemi, Maryam Farahhal, et al.
…or global health challenge, exacerbated by the rise of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains. Limitations in current antibiotic therapies have intensified interest in alternative antimicrobials, including plant-derived phytochemicals. Essential oi…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
…is reported in several regions. Treatment success rates for drug-sensitive TB reached up to 97%. New regimens incorporating bedaquiline and delamanid for multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) showed cure rates as high as 94.6%. **CONCLUSION:** O…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
…ES:** The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is essential for optimizing trea…