Showing 1–25 of 26 documents
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Ya-Li Chen, Yu He, Victor Naestholt Dahl, Kan Yu, Yan-An Zhang, et al.
…informatics tools for predicting Mycobacterium tuberculosis drug resistance. A systematic review of PubMed, Embase, Scopus, Web of Science, CINAHL and the Cochrane Library was performed to identify studies reporting the effectiveness of bioinformatic tools for predicting resistan…
Xinru Xu, Yanyi Lei, Li Zheng
… nationwide data on epidemiology, species distribution, and drug resistance patterns have been lacking. This study aimed to systematically evaluate the prevalence, geographical and temporal trends, species composition, and antimicrobial resistance of NTM in mainland China and Tai…
Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) remains a formidable public health challenge, posing a significant threat to human life and health security. Comprehensive comparative evidence on the efficacy and safety of various DR-TB treatment strategies remains limited. Th…
Denekew Tenaw Anley, Melaku Ashagrie Belete, Ermias Sisay Chanie, Anteneh Mengist Dessie, Melkamu Aderajew Zemene, et al.
Tuberculosis (TB) remains a global health challenge, with drug-resistant (DR) forms of the disease posing a significant threat to effective disease control. Prognostic models are crucial tools that aid in clinical decision-making by predicting the likelihood of adverse treatment …
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk fac…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…se events (AEs) associated with the new shorter regimen for drug-resistant tuberculosis (TB) containing a bedaquiline-pretomanid-based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by comb…
XiaoBo Wei, Norhashimah Mohd Norsuddin, Hamzaini Bin Abdul Hamid, Mohd Imree Azmi, GuiLan Zhang, et al.
…ystematic evidence on its role in predicting and diagnosing drug-resistant tuberculosis (DR-TB) is lacking. This study integrates a systematic review and meta-analysis to consolidate ML's performance in DR-TB diagnosis and prediction to promote artificial intelligence in this fie…
Edward Masoambeta, Charity Mkwanda, Edna Ibrahim, Kenneth Chizani, Chikondi Chapuma, et al.
…ined methodologies used to cost the impact of antimicrobial resistance (AMR) infections in humans from household and health system perspectives. Although extensive research has been conducted on the clinical AMR burden in low- and middle-income countries (LMICs) in terms of preva…
Helen Zhang, Naomi Medina-Jaudes, Alicia Forcada-Nadal, Ewan M Harrison, Francesc Coll
…utated MTBC loci across patients and estimated the rates of drug resistance (DR) acquisition during treatment. **RESULTS:** Using 5882 high-quality genomes from 1044 patients with TB, we identified 21 genes, 25 operons, and 27 promoter regions statistically enriched by mutations…
Erum Siddiqui, Mohammad Saad Khan, Maliha Khalid, Harshika Khaim Chandani, Umaimah Naeem, et al.
…olution in combating TB, particularly in the face of rising drug-resistant strains and suboptimal current vaccines. It has the potential to address the unmet need for more effective interventions against drug-resistant TB, a growing global health issue that continues to challenge…
David J Horne, Jerry S Zifodya, Adrienne E Shapiro, Elizabeth Chandler Church, Jonah S Kreniske, et al.
…est that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF. **OBJECTIVES:** To determine the diagnostic accuracy of Xpert MTB/RIF Ul…
Maja L Brinch, Andrea Palladino, Jeroen Geurtsen, Thierry Van Effelterre, Lorenzo Argante, et al.
**BACKGROUND:** In the fight against antimicrobial resistance, mathematical transmission models have been shown as a valuable tool to guide intervention strategies in public health. **OBJECTIVE:** This review investigates the persistence of modelling gaps identified in earlier s…
Malika Idayat, Elena von der Lippe, Nailya Kozhekenova, Oyunzul Amartsengel, Kamila Akhmetova, et al.
…/RIF, 89-96% sensitivity and 98% specificity for rifampicin resistance). Diagnostic turnaround times ranged from hours (molecular) to weeks (conventional). Only 58% of TB facilities had GeneXpert technology, with urban-rural disparities in diagnostic access. Drug-resistant TB imp…
Alfred Ngwira, Samuel Manda, Esron Daniel Karimuribo, Sharadhuli Iddi Kimera
…fects the cattle economy in Africa, with zoonotic TB posing drug-resistance issues in humans. The burden of TB in cattle and zoonotic TB in humans in sub-Saharan Africa (SSA) is not well understood. This study aimed to determine the prevalence of both TB in cattle and zoonotic TB…
Omayma Benbrik, Oumaima Bounar, Imad Chakri, Laila Lahlou, Hind Serhane
…a random-effects model. Subgroup analyses were performed by drug-susceptibility status and treatment history. Heterogeneity was assessed using the I² statistic, and risk of bias was evaluated using Joanna Briggs Institute Critical Appraisal Checklists of prevalence and case …
I Made Bayu Anggriawan, Ike Dhiah Rochmawati
…s has contributed to the rising prevalence of antimicrobial resistance. However, limited studies have systematically analyzed the prevalence of fluoroquinolone resistance (FQR) and its associated risk factors. **METHODS:** A systematic review and meta-analysis were conducted, sc…
Johnessa Cung, Patihul Husni, Kyung Taek Oh
… treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evaluates recent advancement in actively targeted nanoparticle (NP) systems designed to improve TB diagnosis, tre…
Sanjay Singhal, Ranganath Ganga, Pulkit Gupta, Aneeket Rastogi, Shilpi Arya, et al.
…* With the increasing use of Linezolid for the treatment of drug-resistant tuberculosis, concerns have emerged about serious adverse effects, including optic neuritis. **OBJECTIVES:** To systematically review available evidence on the incidence reported in the cohort, onset, lin…
Ravindra Kumar Garg, Rajiv Garg, Akshaya Anand Agrawal, Sanjay Singhal, Raza Abbas Mahdi
… 38.4%. Anti-TB therapy was administered to 79.5%; 8.2% had drug-resistant TB. Neonatal TB manifestations included congenital TB (39.7%), miliary TB (34.2%), and CNS TB (15.1%). Of 55 live births, 28 infants survived, 12 died neonatally, and outcomes were missing for 15; there we…
Ana Luíza Brasileiro Nato Marques Assumpção, Flávia Correia Silva, Licia Kellen de Almeida Andrade, Quézia Rosa Ferreira, Gilberto da Cruz Leal, et al.
…dies focused on pulmonary tuberculosis, with one addressing drug-resistant tuberculosis. The results revealed that women's experiences with tuberculosis are shaped by the following four thematic categories: (1) stigma and social vulnerability of women with tuberculosis; (2) gende…
Hanxin Wu, Liangyu Zhu, Rui-An Bao, Suyi Luo, Li Peng, et al.
…al attainment 0.39 % (95 % CI: 0.31 to 0.47), and drug-resistant tuberculosis 7.0 % (95 % CI: 4.6 to 9.4) as significantly associated with higher co-infection prevalence. Regional variation was also significant, with Africa showing the highest burden. No assoc…
Emilyn Costa Conceição, Felicia Wells, Abhinav Sharma, Mishka Haffejee, Brendon Mann, et al.
…) holds promise for accurate and comprehensive diagnosis of drug resistance inand identification of transmission events. 'Early positive cultures' (EPC) are increasingly used when WGS is implemented to guide clinical care to reduce the turnaround time. We performed a systematic l…
Maria-Angelica B Lerma, Ayla Niel L Castillo, Gelza Mae A Zabat
… status (sufficiency/insufficiency/deficiency), presence of drug resistance, and genetic polymorphisms; these may be explored in future studies sufficiently powered to examine such a relationship.
Olivia Alise D'Silva, Samantha Lancione, Oviya Ananthakrishnan, Angelina Addae, Suvesh Shrestha, et al.
…94 USD. Costs were consistently higher amongst persons with drug resistant TB (DR-TB) and those identified through passive case finding (PCF). Hospitalization and loss of income were the largest drivers of cost. Despite many countries offering free TB treatment, patients still in…
Saeid Sadeghi Ghazi Chaki, Saeed Babaie Pirsoltan, Masoumeh Beig, Tahereh Navidifar, Elnaz Parvizi, et al.
**BACKGROUND:** Macrolide resistance in Mycobacterium species is an emerging global problem, complicating treating non-tuberculous mycobacteria (NTM) and Mycobacterium tuberculosis. Understanding global resistance patterns is essential to improve treatment strategies and reduce m…