Showing 1–25 of 74 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
**BACKGROUND:** Drug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-r…
Kabelo Gabriel Kaapu, Vukosi Treasure Makondo, Emilyn Costa Conceição, Ivy Rukasha
: Bedaquiline (BDQ) resistance poses a serious threat to its long-term efficacy, particularly in high-burden settings like South Africa, where data remain scattered and largely non-synthesized.: This study aimed to estimate the trends of BDQ resistance in drug resistant tuberculo…
Xinyang Hu, Zhiwei Wu, Jing Lei, Yanqin Zhu, Jingtao Gao
**BACKGROUND:** Drug-resistant tuberculosis (TB) remains a major global public health challenge. While bedaquiline (BDQ) offers improved treatment outcomes for patients with multi-drug resistant TB (MDR-TB), its widespread use has led to the emergence of BDQ resistance. **METHOD…
Ya-Li Chen, Yu He, Victor Naestholt Dahl, Kan Yu, Yan-An Zhang, et al.
…informatics tools for predicting Mycobacterium tuberculosis drug resistance. A systematic review of PubMed, Embase, Scopus, Web of Science, CINAHL and the Cochrane Library was performed to identify studies reporting the effectiveness of bioinformatic tools for predicting resistan…
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia
: The use of linezolid in drug-resistant tuberculosis has shown good effectiveness but has a high risk of adverse drug reactions (ADRs). Linezolid-related ADRs have been widely reported and may affect their therapeutic effect. This systematic review aimed to describe linezolid-re…
Mansour Kargarpour Kamakoli, Ehsan Zare BanadKoki, Mehran Nakhaeizadeh, Ava Behrouzi, Nasim Ebrahimifard, et al.
**BACKGROUND:** Monitoring the genetic diversity of the drug-resistant(Mtb) population contributes to gaining better insight into the bacterial dynamics and informing effective strategies to tackle the challenge of drug resistance. This meta-analysis study investigates the pooled…
Rohan Shrivastava, Kashmi Sharma, Somesh Mishra, Poonam Parihar, Gobardhan Das, et al.
…osis (TB) remains a leading infectious cause of death, with drug-resistant TB threatening control gains worldwide Rapid, accurate prediction of resistance to first-line agents is essential to guide therapy. The objective of this meta-analysis is to evaluate the diagnostic perform…
Muluneh Assefa, Mitkie Tigabie, Azanaw Amare, Getu Girmay, Alene Geteneh, et al.
**INTRODUCTION:** The growing challenge of antimicrobial resistance in Ethiopia and itsprogression towards XDR and PDR has become a critical public health concern. Therefore, thisreview determined the current state of emerging XDR and PDR bacteria, including pre-XDR and XDR-TB, t…
Wamaka Kaminyoge, Reuben Simfukwe, Mwiza Singini, Norman Sitali, Felix P Chilunga
**BACKGROUND:** Children and adolescents with multidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis (TB) face major treatment challenges. Although newer all-oral regimens have transformed adult TB care, their use in younger populations has largely been extrap…
Salman Daneshi, Esmaeil Barkhori Mehni, Mohammad Kamali, Eshagh Barfar, Fatemeh Bagher Barahouei, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) is an increasing public health concern in Iran, with multidrug-resistant tuberculosis (MDR-TB) posing significant challenges to disease control efforts. This study examines the prevalence of DR-TB in Iran from January 2000 to …
Timothy Hudson David Culasino Carandang, Dianne Jaula Cunanan, Gail S Co, John David Pilapil, Juan Ignacio Garcia, et al.
…e sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial for effective TB control. This study synthesized current evidence on the diagnostic accuracy of the nanopore sequencing technology in detecting MTB and its DST profile.…
Xinru Xu, Yanyi Lei, Li Zheng
… nationwide data on epidemiology, species distribution, and drug resistance patterns have been lacking. This study aimed to systematically evaluate the prevalence, geographical and temporal trends, species composition, and antimicrobial resistance of NTM in mainland China and Tai…
Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) remains a formidable public health challenge, posing a significant threat to human life and health security. Comprehensive comparative evidence on the efficacy and safety of various DR-TB treatment strategies remains limited. Th…
Christina Zouganeli, Dimitra K Toubanaki, Ourania Karaoulani, Georgia Vrioni, Evdokia Karagouni, et al.
…antly intensified global concerns surrounding antimicrobial resistance (AMR), particularly in relation to tuberculosis (TB). In the European Union (EU), the reallocation of healthcare resources towards managing COVID-19 led to a de-prioritization of TB surveillance and control. T…
Cornelius Gweba, Adegboyega Omoniyi Oyefabi, Abimbola Awopeju, Regina Doro Jabaka, Leonard Ighodalo Uzairue
**INTRODUCTION:** The emergence of multidrug-resistant tuberculosis has eroded the gains made in the fight against tuberculosis. This review aims to provide current perspectives on the lineages of thecomplex (MTBC) associated with drug-resistant tuberculosis (DR-TB) in Africa. *…
Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xiaohan Chen, Yan He, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) presents a significant global obstacle to TB control efforts, necessitating improved intervention strategies. The introduction of potent drugs, such as bedaquiline (Bdq), has led to the development of shorter treatment regimens.…
Denekew Tenaw Anley, Melaku Ashagrie Belete, Ermias Sisay Chanie, Anteneh Mengist Dessie, Melkamu Aderajew Zemene, et al.
Tuberculosis (TB) remains a global health challenge, with drug-resistant (DR) forms of the disease posing a significant threat to effective disease control. Prognostic models are crucial tools that aid in clinical decision-making by predicting the likelihood of adverse treatment …
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk fac…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…se events (AEs) associated with the new shorter regimen for drug-resistant tuberculosis (TB) containing a bedaquiline-pretomanid-based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by comb…
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
…n Sub-Saharan Africa, exacerbated by the high prevalence of drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for DR-TB, including multidrug-resistant TB (MDR-TB) and extensively DR-TB (XDR-…
XiaoBo Wei, Norhashimah Mohd Norsuddin, Hamzaini Bin Abdul Hamid, Mohd Imree Azmi, GuiLan Zhang, et al.
…ystematic evidence on its role in predicting and diagnosing drug-resistant tuberculosis (DR-TB) is lacking. This study integrates a systematic review and meta-analysis to consolidate ML's performance in DR-TB diagnosis and prediction to promote artificial intelligence in this fie…
Yipeng Sun, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib
… accelerate the time to culture conversion in patients with drug-resistant tuberculosis (DR-TB). However, pulmonary lesion improvement based on chest imaging after BDQ treatment has not been evaluated. We aimed to evaluate pulmonary lesion improvement in patients with DR-TB follo…
Getu Diriba, Ayinalem Alemu, Abyot Meaza, Muluwork Getahun, Getachew Seid, et al.
… no routine screening for TB during prison admission. Also, drug-resistant tuberculosis (DR-TB) is a significant public health problem. Prisons are the most important permissive environments for TB transmission. However, less attention has been given to this segment of the popula…
Oumar Abakar Mahamed, Noussissy Sandokane Hounnoukon, Soraya Laraqui Houssaini, Imane El Faziki, Meryeme Kirat, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) is a constraining challenge for tuberculosis (TB) control worldwide. The Middle East and North African (MENA) region represents a significant part of the global MDR-TB burden. **AIM:** To estimate the pooled prevalence of…
Edward Masoambeta, Charity Mkwanda, Edna Ibrahim, Kenneth Chizani, Chikondi Chapuma, et al.
…ined methodologies used to cost the impact of antimicrobial resistance (AMR) infections in humans from household and health system perspectives. Although extensive research has been conducted on the clinical AMR burden in low- and middle-income countries (LMICs) in terms of preva…