Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Yihui Zhou, Hongxia Niu
Tuberculosis (TB) remains a global public health emergency, with multidrug-resistant TB (MDR-TB) and rifampicin-resistant TB (RR-TB) posing critical challenges. Conventional longer regimens are characterized by suboptimal effectiveness, high toxicity, and poor tolerability. Conse…
Seyed Alireza Mortazavi, Nicole A Swartwood, Nanki Singh, Melike Hazal Can, Hening Cui, et al.
…D:** Urban and rural settings differ in key determinants of tuberculosis (TB) burden, including transmission dynamics, social and structural determinants, and healthcare access. However, understanding of urban and rural TB burden is limited, hindering implementation of public hea…
Yipeng Sun, Idris Sula, Muhammad Candragupta Jihwaprani, Nazmus Saquib
… time to culture conversion in patients with drug-resistant tuberculosis (DR-TB). However, pulmonary lesion improvement based on chest imaging after BDQ treatment has not been evaluated. We aimed to evaluate pulmonary lesion improvement in patients with DR-TB following treatment …
Beatriz Barreto Duarte, Jerrold Ellner, Alicia D Wright, Mark Hatherill, Amita Gupta, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading infectious cause of death globally. While control strategies have traditionally prioritized symptomatic cases, growing evidence highlights the substantial burden of asymptomatic or subclinical TB, microbiologically confirmed dis…
Isabelle Munyangaju, Lucía Carratalà-Castro, Dulce Osório, Jacob Bigio, Kondwelani John Mateyo, et al.
Diagnosing tuberculosis (TB) in children is challenging due to non-specific symptoms, paucibacillary disease, and difficulty producing sputum. Chest X-rays (CXRs), though widely used, are often inaccessible in low-resource settings and involve radiation. Ultrasound (US) is a radi…
Shunli Cai, Tianwei Yan, Yutian Yang, Xin Guo, Xiang Li, et al.
…(BCG) vaccination is well established for preventing severe tuberculosis (TB) in children; however, its effectiveness in reducing the progression of latent TB infection (LTBI) to active disease remains uncertain, particularly in real-world contact settings. **METHODS:** We condu…
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
…n (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analysis (NMA). **DATA SOURCES:** PubM…
Kindie Fentahun Muchie, Frank Tobian, Mary Gaeddert, Claudia Maria Denkinger, Johanna Kellett Wright, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major global health challenge, with an estimated 10.8 million new cases and 1.25 million deaths in 2023. Despite advances in molecular detection of Mycobacterium TB (MTB), significant diagnostic gaps remain: in 2023, onl…
TianYu Lin, Sheng Liu, Yan-Yu Pan
**BACKGROUND:** Tuberculosis (TB) remains a leading global cause of infectious mortality. Accelerating vaccine development requires validated immune correlates of protection (CoPs). Mechanistic studies have long highlighted Th1 cytokines (IFN-γ, IL-2, TNF-α) as crucia…
Qin Chen, Ningjun Ren, Shengya Liu, Zixin Qian, Mengdie Li, et al.
**BACKGROUND:** Tuberculosis (TB) continues to pose a significant global public health threat, particularly among migrant populations. Screening policies exist in many receiving countries but differ markedly, and there is limited pooled evidence on TB and latent TB infection (LTB…
Aminat Y Saula, Muge Cevik, Jacqueline M Cliff, Katharina Ronacher, Ruth Bowness
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, and the rising prevalence of diabetes mellitus (DM) represents a major obstacle to TB control. DM increases susceptibility to TB, worsens disease severity, delays treatment respon…
Youssra Metarfi, Wissal Chellal, Zineb Ben Khadda, Hasnae Hoummani, Bouchra Amara, et al.
**BACKGROUND AND OBJECTIVES:** The treatment of tuberculosis (TB) depends on anti-TB drugs to eradicate the infection and prevent its transmission. Variability in drug metabolism, interactions, and adherence can affect treatment efficacy. Therapeutic drug monitoring (TDM) is esse…
Zi-Ke Chen, Zhao Wu, Ting Ye, Chao-Yang Lin, Xu-Guang Guo
…xhibited high diagnostic efficiency in detecting lymph node tuberculosis (LNTB). However, different gold standards and types of LNTB specimens may impact Xpert's diagnostic accuracy. This meta-analysis compared the performance of Xpert MTB/RIF on fine needle aspiration (FNA) and …
Paul W Bird, Daniel Pan, Kentaro Trerattanavong, Christopher A Martin, Christopher Holmes, et al.
…rom countries with high incidence of communicable diseases [tuberculosis (TB), HIV, and hepatitis B (HBV) and C (HCV)]; has increased the need for cost-effective early disease diagnosis programmes to improve outcomes. We aimed to synthesize and evaluate current literature on comm…
Michael Prodanuk, Sarah L Silverberg, Pierre-Philippe Piché-Renaud, Daniel S Farrar, Jessie Cunningham, et al.
…ization (WHO) increased the recommended doses of first-line tuberculosis (TB) drugs for children. In this systematic review, we aimed to determine the proportion of children who developed adverse events (AEs) on first-line TB treatment and determine whether a change in toxicity w…
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major public health challenge in Sub-Saharan Africa, exacerbated by the high prevalence of drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for…
Agus Santosa, Neti Juniarti, Tuti Pahria, Raini Diah Susanti
Medication adherence is critical for successful tuberculosis (TB) treatment, yet non-adherence remains a major barrier to TB control globally. Digital adherence technologies (DAT) have emerged as promising tools to support adherence, but their effectiveness remains variably repor…
Juan Espinosa-Pereiro, Ana Aguiar, Eva Nara, Angelica Medina, Gladys Molinas, et al.
…cin could improve the treatment outcome of drug-susceptible tuberculosis (TB) without compromising the safety of patients. **METHODS:** We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin dos…
Kylie Tingley, Angela Li, Emily L MacLean, Becky Skidmore, Nawal Maredia, et al.
**BACKGROUND:** Tuberculosis (TB) remains a global health threat, with millions of new infections annually. While most infected individuals remain asymptomatic, a subset progresses to active disease. Effective tests predicting TB progression are urgently needed to enhance prevent…
Alicia E Madden, Sylvia K Ofori, Marian Budu, Emnet Sisay, Brian Dooley, et al.
**BACKGROUND:** Tuberculosis (TB) is a major global health concern, with long-term complications persisting even after successful treatment. Chronic pulmonary aspergillosis (CPA) is a progressive fungal disease that frequently develops in TB survivors, contributing to post-TB lun…
Omri A Arbiv, Thomas Holmes, Marie JeongMin Kim, Marie Yan, Kamila Romanowski, et al.
…n (SDR) with TDR and/or double-dose rifampin (DDR) in human tuberculosis treatment. The primary outcome was pooled incidence rate ratio (IRR) of severe adverse events (SevAEs) between participants who received TDR and those who received SDR. Pooled relative risk (RR) of death was…
Zikang Sheng, Lin Zeng, Yue Zhang, Hongbin Chi, Xiaoyan Gai, et al.
**OBJECTIVES:** Tuberculosis (TB) is a common cause of infertility in humans, especially in regions with high TB prevalence. However, the impact of latent TB infection (LTBI) on pregnancy outcomes following assisted reproduction in patients with infertility remains unclear. This …
Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk fac…
Bibie Said, Yuan Pétermann, Patrick Howlett, Monia Guidi, Yann Thoma, et al.
…HIV) infection, diabetes mellitus (DM), and malnutrition in tuberculosis (TB) patients can alter drug concentrations, thereby affecting the treatment outcomes. For these populations, personalised strategies such as therapeutic drug monitoring (TDM) may be essential. We investigat…
Kayla Appel, Faeez Nackerdien, Carmen S Christian
**BACKGROUND:**  Tuberculosis (TB) remains a major public health issue in South Africa, a high-burden TB country. The coronavirus disease 2019 (COVID-19) pandemic has exacerbated challenges in accessing essential TB services. This scoping review explores how access to TB car…