Showing 151–175 of 200 documents
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Heda Melinda Nataprawira, Intan M W Dewi, I Gusti Agung Ayu Novi Wiraningrat, Citra Cesilia
**INTRODUCTION:** Post-tuberculosis lung disease (PTLD) causes health problems among pulmonary TB (PTB) survivors. Post-TB patients may suffer from chronic respiratory symptoms, declining lung function, and persistent radiological abnormalities. However, studies regarding PTLD in…
Yilu Zhao, Yiran Han, Jia Liu, Honghong Niu, Peilong Wang, et al.
**BACKGROUND:** Pulmonary tuberculosis (PTB), an ancient affliction, continues to present significant challenges in modern medicine. Baihe Gujin Decoction, a traditional Chinese botanical drug remedy, has been widely utilized in clinical practice for tuberculosis treatment, yet i…
Rosita Dwi Yuliandari, Chatarina Umbul Wahyuni, Fariani Syahrul, Hari Basuki Notobroto, Mochammad Bagus Qomaruddin, et al.
**BACKGROUND:** Despite the significant efforts in tuberculosis (TB) management, TB case detection remains a challenge in developing countries. Traditional methods such as Directly Observed Treatment Short-course (DOTS) have often underperformed, necessitating the implementation …
Bewket Mesganaw, Ketema Misganaw, Mekuriaw Belayneh
**BACKGROUND:** Reliable tuberculosis (TB) diagnosis is central to TB control programs, particularly in high-burden countries such as Ethiopia. External Quality Assessment (EQA) is a core component of laboratory quality assurance, encompassing blinded rechecking, panel testing, a…
Gauri Shankar, Yusuf Akhter
…sets (GSE8732 and GSE84554) to elucidate Mycobacterium tuberculosis (Mtb)'s transcriptional response to iron limitation, a key host defense mechanism. The study identifies a core set of consistently differentially expressed genes (DEGs) critical for Mtb's survival …
Qonita Nur Miladi, Tuti Pahria, Iqbal Pramukti
**BACKGROUND:** Pulmonary tuberculosis (TB) remains a global health concern with high morbidity and mortality rates. Despite being curable with proper treatment, challenges in ensuring continuity of care persist, particularly in resource-limited settings. Digital health intervent…
Jincheng Huang, Jinjie Xia, Binxue Hong, Can Zhang, Li Zhao, et al.
… aims to evaluate the risk factors and prevalence of latent tuberculosis infection (LTBI) in patients with rheumatic diseases. **METHODS:** Databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Vip, and Wanfang were searched. Data extraction was performed i…
Mohd Jaish Siddiqui, Abhishek Karmacharya, Xuemeng Wan, Yu Zhu, Chaomin Wan, et al.
**INTRODUCTION:** Abdominal tuberculosis (ATB) in children is an uncommon form of extrapulmonary tuberculosis that often presents with non-specific symptoms. These features frequently overlap with other abdominal conditions, increasing the risk of misdiagnosis or delay in diagnos…
Aboudou Habirou Kifouly, Orléanse Kouin, Géorcelin Alowanou, Obase Ngemani Bekindaka, Pierre Challaton, et al.
**INTRODUCTION:** Bovine tuberculosis (bTB), caused by, is a chronic zoonotic disease of major global importance, particularly in low- and middle-income countries where surveillance and control remain inadequate. **OBJECTIVES:** This systematic review and meta-analysis aimed to …
Ravindra Kumar Garg, Shweta Pandey, Raza Abbas Mahdi, Sanjay Singhal
**BACKGROUND:** Tuberculosis (TB) affecting the central nervous system (CNS) can lead to a broad range of movement disorders, which are frequently overlooked in clinical settings. This review explores the various presentations, underlying mechanisms and patient outcomes related t…
Ze-Jun Zhou, Hai-Yan Xie, Luca Bertolaccini, Ning Xia, Yu Zhang
**BACKGROUND AND OBJECTIVE:** Pulmonary tuberculosis (PTB) and lung cancer (LC) are both serious health threats and have a complex relationship. Research has shown that tuberculosis (TB) may induce LC through chronic inflammation. TB infection is also more common in LC patients t…
Natthakan Chitpim, Panida Yoopetch, Jiraphun Jittikoon, Wanvisa Udomsinprasert, Kornkanok Bunwong, et al.
…says such as Xpert MTB/RIF and TB-LAMP accelerate pulmonary tuberculosis (TB) diagnosis but are more expensive than smear microscopy. This study provided an updated economic synthesis for presumptive adult pulmonary TB in high-burden settings, broadening the evidence from Xpert M…
Syed Saad Ali, Wifag Medani Malik, Sandhya Narahari, Dani Badal Hayder, Naheemat Mofolasayo Salimon, et al.
Tuberculosis meningitis (TBM) represents the most severe type of tuberculosis (TB), and it is characterized by high mortality and neurological complications. Rifampicin is a major part of the standard treatment of TB; however, conventional doses often achieve subtherapeutic level…
Qi Wang, Xiao-Nan Wang, Xiao-Qun Liu, Long-Ge Zhao, Zi-Tong Jing, et al.
**BACKGROUND:** Bovine tuberculosis (bTB) is a zoonotic disease caused by members of the Mycobacterium tuberculosis complex (MTBC), with Mycobacterium bovis being the primary agent responsible for infections in cattle, posing a significant threat to the global dairy industry. Alt…
Xin-Yu Shi, Yi-Xiao Zhang, Shu-Feng Dong, Qing-Yu Chen, Feng-Shuang Yi
**BACKGROUND:** In regions with a high prevalence of tuberculosis, it is crucial to accurately differentiate between tuberculosis pleural effusion (TPE) and parapneumonic effusion (PPE). The current study aimed to evaluate the potential role of the pleural fluid lactate dehydroge…
Sudarto Sudarto, Zen Hafy, Irsan Saleh, Iche Liberty, Zen Ahmad, et al.
Pulmonary tuberculosis (TB) remains a global health threat, with individual genetic determinants like Toll-like receptor 2 (TLR2) gene variations potentially modulating immune responses to. This systematic review evaluates the role of TLR2 polymorphisms in influencing susceptibil…
Namitha, Priyanka, Monika Sharma, Sadhna Sharma
**BACKGROUND:** Globally, tuberculosis (TB) is a significant health issue, and both latent and active TB pose considerable public health risks. Adequate vitamin D is crucial in immune regulation, and its deficiency raise the odds of developing TB. There is still uncertainty about…
Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
**BACKGROUND:** Diagnosing extrapulmonary tuberculosis (EPTB) in children is challenging due to nonspecific presentations and poor diagnostic yield from conventional microbiologic tests. Host gene expression signatures offer a non-sputum-based diagnostic alternative. This systema…
B C Mann, J Loubser, S Omar, C Glanz, Y Ektefaie, et al.
…e genome sequencing (dsWGS) can revolutionize Mycobacterium tuberculosis (Mtb) diagnosis by enabling rapid detection clinically relevant resistance mutations and strain diversity without the biohazard of culture. We searched PubMed, Web of Science, and Google Scholar, identifying…
Johnessa Cung, Patihul Husni, Kyung Taek Oh
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, hampered by prolonged, toxic treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evalu…
Shunli Cai, Qingyi Luo, Guozhong Zhou, Xin Guo, Yan Dong, et al.
…e Bacillus Calmette-Guérin (BCG) vaccine in preventing tuberculosis (TB) infection in children. **METHODS:** PubMed, Web of Science, Cochrane, and Embase were searched from their inception to January 12, 2025. Studies were included if they focused on children under 19 years…
Amit Harshana, Mohit Goyal, Augustine Chako, Raman Mahajan
The dual burden of HIV and tuberculosis (TB) impacts people living with HIV (PLHIV) coinfected with TB. Although some primary studies have been reported on the burden of extrapulmonary TB (EPTB) among PLHIV in Southeast Asia (SEA), there is no systematic review or meta-analysis t…
Xuling Chang, Zheng Li, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thuy Thuong Thuong, et al.
**BACKGROUND:** Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very li…
Syed Hassan Ali, Shanza Shakir, Umais Ahmed Shaikh, Maryam Khalid, Maria Jawed, et al.
Tuberculosis (TB) remains a leading global cause of death. While primary Bacillus Calmette-Guérin (BCG) vaccination offers protection in children, the role of BCG revaccination in adults remains unclear. This study evaluated the efficacy, immunogenicity, and safety of BCG re…
Ravindra Nath, Nitin Panwar, Aninda Debnath, Anirban Bhaumik, Jugal Kishore, et al.
Tuberculosis (TB) poses a significant occupational hazard for healthcare workers (HCWs) in India, a country bearing a substantial portion of the global TB burden. This systematic review and meta-analysis aims to determine the prevalence of TB among HCWs in India. Analyzing 10 stu…