Showing 126–150 of 151 documents
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Ruan Spies, Derrick W Crook, Timothy E A Peto, Philip W Fowler, Robert Turner, et al.
…ipelines could address this inequity in access to WGS-based diagnostics and surveillance. This study aimed to systematically evaluate the performance and usability of publicly available WGS pipelines for M tuberculosis. **METHODS:** We identified automated M tuberculosis WGS ana…
Rui Zhang, Mengdie Wang, Xinyu Liu, Feifei Yang, Xinyuan Xu, et al.
Spinal infections (SI) are on the rise due to an aging population and the prevalence of more invasive procedures. This study aims to systematically review the microbiological spectrum of SI to enhance diagnostic accuracy and inform effective antibiotic treatment strategies. The l…
Marta Nerini, Anisa Ribani, Stefania Papa, Duccio Cavalieri, Massimiliano Marvasi
…acteria, supporting the development of drugs, vaccines, and diagnostics without the constraints of BSL-3 laboratories. However, limitations remain-particularly in drug screening with M. smegmatis and the underrepresentation of environmental studies. The use of surrogates supports…
Ashish Satav, Dhananjay Raje, Vibhawari Dani, Radha Munje, Shraddha Kumbhare, et al.
**BACKGROUND:** Tribal communities in India experience a very high burden of tuberculosis (TB), estimated at 7030 per million. The diagnosis and notification gaps are substantial, partly due to the geographical remoteness of these populations. Within an overarching study to desig…
Xianni Wei, Ruina Cai, Xiaohong Wu, Yonglong Su, Siheng Lian, et al.
**PURPOSE:** Antituberculosis drug-induced liver injury (ATLI) is a common and serious adverse drug reaction of tuberculosis treatment. The impact of ATLI in patients with chronic hepatitis C is unclear. The aim of this study is to evaluate the prevalence of DILI in patients with…
Alicia E Madden, Sylvia K Ofori, Marian Budu, Emnet Sisay, Brian Dooley, et al.
**BACKGROUND:** Tuberculosis (TB) is a major global health concern, with long-term complications persisting even after successful treatment. Chronic pulmonary aspergillosis (CPA) is a progressive fungal disease that frequently develops in TB survivors, contributing to post-TB lun…
Mary Gaeddert, Penelope Papadopoulou, Jennifer Habbes, Tobias Niederegger, Lukas Schik, et al.
**BACKGROUND:** The diagnosis of tuberculosis (TB) typically relies on being able to produce a sputum sample for microbiological testing. However, sputum scarcity, the inability to self-expectorate an adequate sputum sample for TB testing, is a well-known concern. Our systematic …
Mary Gaeddert, Jennifer Habbes, Julian Meister, Ashlyn Beecroft, Amelie von Saint Andre-von Arnim, et al.
…rnative methods, such as induction or gastric aspirates. TB diagnostics using samples that are easier to collect from children in resource-limited settings are needed. **FUNDING:** Gates Foundation (INV-069540).
Abisola R Isaiah, Monray Williams, Du Toit Loots, Aurelia A Williams, Novel N Chegou, et al.
**UNLABELLED:** Tuberculosis (TB) is the leading cause of death from a single infectious agent, with approximately 1.2 million deaths reported in 2023. While TB primarily affects the lungs, it can also spread to other organs, where it is classified as extrapulmonary TB. Tube…
Christina Zouganeli, Dimitra K Toubanaki, Ourania Karaoulani, Georgia Vrioni, Evdokia Karagouni, et al.
: The COVID-19 pandemic has significantly intensified global concerns surrounding antimicrobial resistance (AMR), particularly in relation to tuberculosis (TB). In the European Union (EU), the reallocation of healthcare resources towards managing COVID-19 led to a de-prioritizati…
Dawit Gebremichael
Bovine tuberculosis (bTB) has significant economic losses on the livestock productivity and poses serious public health risks worldwide. In Ethiopia, bTB is endemic and distributed across all parts of the country. Therefore, the systematic review aims to provide comprehensive inv…
Zhen Feng, Hailan Wu, Qian Li, Xiaoqiang Zhang, Qingfeng He, et al.
**OBJECTIVES:** High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens. **DESIGN:** Using a systematic review and Bayesian network meta-analy…
Natthakan Chitpim, Panida Yoopetch, Jiraphun Jittikoon, Wanvisa Udomsinprasert, Kornkanok Bunwong, et al.
**PURPOSE:** Rapid molecular assays such as Xpert MTB/RIF and TB-LAMP accelerate pulmonary tuberculosis (TB) diagnosis but are more expensive than smear microscopy. This study provided an updated economic synthesis for presumptive adult pulmonary TB in high-burden settings, broad…
Samin Afazel, Mohammad J Nasiri, Vishwanath Venketaraman
**INTRODUCTION:** Tuberculous meningitis (TBM) remains a leading cause of mortality and neurological disability in both children and adults. This systematic review and meta-analysis aim to assess the treatment outcomes of anti-tuberculosis drugs in TBM patients, focusing on morta…
Sumeet Mirgh, Uday Yanamandra, Ganesh K Vishvanathan, Sadashivudu Gundeti, Navin Khattry, et al.
**BACKGROUND:** Amyloidosis is a condition characterized by deposition of insoluble protein fibrils in tissues, leading to diverse clinical manifestations. There is limited data addressing amyloidosis from India. **OBJECTIVE:** This study aims to systematically review the availa…
Sareh Bagheri-Josheghani, Zahra Rafat, Parivash Davoodian, Mehdi Hassani Azad, Afsaneh Karmostaji, et al.
Co-infection of tuberculosis (TB) and cryptococcosis as a consequence of impaired cell-mediated immune responses is accompanied by high mortality and morbidity rates. This study aimed to provide valuable insights into risk factors, diagnostic tests, and treatment methods used for…
Ni Chen, Limei Hong, Hanlin Liang, Qingliang Yu, Siqiao Liang, et al.
**INTRODUCTION:** Anti-interferon-γ autoantibodies (AIGAs) syndrome is a rare, adult-onset immunodeficiency characterized by increased susceptibility to various opportunistic infections. Currently, there are no standardized diagnostic or therapeutic guidelines for AIGAs syn…
Amit Harshana, Mohit Goyal, Augustine Chako, Raman Mahajan
The dual burden of HIV and tuberculosis (TB) impacts people living with HIV (PLHIV) coinfected with TB. Although some primary studies have been reported on the burden of extrapulmonary TB (EPTB) among PLHIV in Southeast Asia (SEA), there is no systematic review or meta-analysis t…
Kayla Appel, Faeez Nackerdien, Carmen S Christian
**BACKGROUND:**  Tuberculosis (TB) remains a major public health issue in South Africa, a high-burden TB country. The coronavirus disease 2019 (COVID-19) pandemic has exacerbated challenges in accessing essential TB services. This scoping review explores how access to TB car…
Anis Choucha, Matteo De Simone, Nathan Beucler, Solenne Hulot, Jean-Christophe Lagier, et al.
 Brain abscess is a worrisome condition with a 1-year mortality rate of 21% and a 32% rate of new-onset epilepsy. Brain magnetic resonance imaging (MRI) is strongly recommended as a screening modality with contrast-enhanced T1-weighted images, diffusion-weighted imaging (D…
Romina Lorena de Los Santos-Fernández, Antonio Segovia-Zafra, Guillermo Paz-López, Gonzalo Matilla-Cabello, Hao Niu, et al.
Genetic susceptibility has been identified in idiosyncratic drug-induced liver injury, a potentially severe adverse reaction towards drugs, herbal products and dietary supplements. However, its occurrence cannot be fully explained by the presence of genetic variants in specific g…
Ika Nindya Kadariswantiningsih, Roy Novri Ramadhan, Derren David Christian Homenta Rampengan
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a significant public health issue in Indonesia, a country with a high tuberculosis burden. EPTB accounts for 15%-20% of global TB cases, with the proportion rising in populations co-infected with HIV. In Indonesia, estimates o…
Reagan Daniel Emoru, Lucy Elauteri Mrema, Nyanda Elias Ntinginya, Irene Andia Biraro, Reinout van Crevel, et al.
**OBJECTIVES:** Diabetes mellitus significantly increases the risk of tuberculosis, and active tuberculosis screening of people with diabetes mellitus has been advocated by WHO and other international bodies. This systematic review aimed to evaluate the accuracy of computer-assis…
Carlos Cifuentes-González, Germán Mejía-Salgado, William Rojas-Carabali, Josué Tovar-Tirado, Luis Alejandro Diez-Bahamón, et al.
**PURPOSE:** Scleritis, a severe inflammatory condition of the sclera, causes significant ocular pain and potential tissue damage. Often linked with systemic diseases, scleritis can be either infectious or noninfectious. Despite its clinical importance, the global incidence and d…
Siddique Sehrish, Xue-Tong Liu, Wen-Bo Lou, Shu-Ying Zhang, Emad Beshir Ata, et al.
**BACKGROUND:** Bovine tuberculosis (bTB) primarily caused by, is a globally prevalent zoonotic infectious disease of cattle and other livestock and wildlife species. Pakistan is the fourth-largest milk-producing country in the world, with approximately 212 million animals. Lives…