Showing 101–125 of 200 documents
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Ze-Jun Zhou, Hai-Yan Xie, Luca Bertolaccini, Ning Xia, Yu Zhang
**BACKGROUND AND OBJECTIVE:** Pulmonary tuberculosis (PTB) and lung cancer (LC) are both serious health threats and have a complex relationship. Research has shown that tuberculosis (TB) may induce LC through chronic inflammation. TB infection is also more common in LC patients t…
Syed Saad Ali, Wifag Medani Malik, Sandhya Narahari, Dani Badal Hayder, Naheemat Mofolasayo Salimon, et al.
Tuberculosis meningitis (TBM) represents the most severe type of tuberculosis (TB), and it is characterized by high mortality and neurological complications. Rifampicin is a major part of the standard treatment of TB; however, conventional doses often achieve subtherapeutic level…
Qi Wang, Xiao-Nan Wang, Xiao-Qun Liu, Long-Ge Zhao, Zi-Tong Jing, et al.
**BACKGROUND:** Bovine tuberculosis (bTB) is a zoonotic disease caused by members of the Mycobacterium tuberculosis complex (MTBC), with Mycobacterium bovis being the primary agent responsible for infections in cattle, posing a significant threat to the global dairy industry. Alt…
Qonita Nur Miladi, Tuti Pahria, Iqbal Pramukti
**BACKGROUND:** Pulmonary tuberculosis (TB) remains a global health concern with high morbidity and mortality rates. Despite being curable with proper treatment, challenges in ensuring continuity of care persist, particularly in resource-limited settings. Digital health intervent…
Radwan Darwish, Maya Tama, Sidra Sharief, Osama Zeidan, Sara Mohammed Ahmed Rady, et al.
…sued guidelines for developing a non-sputum test for active tuberculosis (TB) diagnosis that exhibits similar performance characteristics to sputum-based diagnosis, salivary diagnostic techniques have gained prominence as potential screening tools or adjuncts to existing diagnost…
Xin-Yu Shi, Yi-Xiao Zhang, Shu-Feng Dong, Qing-Yu Chen, Feng-Shuang Yi
**BACKGROUND:** In regions with a high prevalence of tuberculosis, it is crucial to accurately differentiate between tuberculosis pleural effusion (TPE) and parapneumonic effusion (PPE). The current study aimed to evaluate the potential role of the pleural fluid lactate dehydroge…
Ricardo Perea-Jacobo, Jose Luis Soto-Ledesma, Rafael Laniado-Laborín, Dora-Luz Flores, Rogelio Zapata-Garibay, et al.
…the available literature on the prevalence and incidence of tuberculosis in incarcerated populations in Latin America and the Caribbean, identifying regional patterns, data gaps, and key challenges and providing recommendations for strengthening TB control strategies within priso…
Rosita Dwi Yuliandari, Chatarina Umbul Wahyuni, Fariani Syahrul, Hari Basuki Notobroto, Mochammad Bagus Qomaruddin, et al.
**BACKGROUND:** Despite the significant efforts in tuberculosis (TB) management, TB case detection remains a challenge in developing countries. Traditional methods such as Directly Observed Treatment Short-course (DOTS) have often underperformed, necessitating the implementation …
Ya-Li Chen, Yu He, Victor Naestholt Dahl, Kan Yu, Yan-An Zhang, et al.
…f various bioinformatics tools for predicting Mycobacterium tuberculosis drug resistance. A systematic review of PubMed, Embase, Scopus, Web of Science, CINAHL and the Cochrane Library was performed to identify studies reporting the effectiveness of bioinformatic tools for predic…
Tingting Li, Huanqing Liu, Qian Lei, Zhuhong You
**BACKGROUND:** Tuberculosis (TB) caused 1.23 million deaths in 2024, with accurate diagnosis hampered by population heterogeneity and limited biomarker generalizability. We developed an integrative framework combining multi-cohort transcriptomics and machine learning to identify…
Pubet Weeranawin, Tanawat Geeratragool, Wanruchada Katchamart, Julajak Limsrivilai
**BACKGROUND/AIMS:** Diagnosis of intestinal tuberculosis (ITB) is challenging. Histopathology and microbiological examination remain the gold standard, but previous studies show varied diagnostic performance. We aimed to systematically evaluate the accuracy of tests to diagnose …
Yilu Zhao, Yiran Han, Jia Liu, Honghong Niu, Peilong Wang, et al.
**BACKGROUND:** Pulmonary tuberculosis (PTB), an ancient affliction, continues to present significant challenges in modern medicine. Baihe Gujin Decoction, a traditional Chinese botanical drug remedy, has been widely utilized in clinical practice for tuberculosis treatment, yet i…
Bewket Mesganaw, Ketema Misganaw, Mekuriaw Belayneh
**BACKGROUND:** Reliable tuberculosis (TB) diagnosis is central to TB control programs, particularly in high-burden countries such as Ethiopia. External Quality Assessment (EQA) is a core component of laboratory quality assurance, encompassing blinded rechecking, panel testing, a…
XiaoBo Wei, Norhashimah Mohd Norsuddin, Hamzaini Bin Abdul Hamid, Mohd Imree Azmi, GuiLan Zhang, et al.
…MS:** Machine learning (ML) has shown promise in diagnosing tuberculosis (TB), but systematic evidence on its role in predicting and diagnosing drug-resistant tuberculosis (DR-TB) is lacking. This study integrates a systematic review and meta-analysis to consolidate ML's performa…
B C Mann, J Loubser, S Omar, C Glanz, Y Ektefaie, et al.
…e genome sequencing (dsWGS) can revolutionize Mycobacterium tuberculosis (Mtb) diagnosis by enabling rapid detection clinically relevant resistance mutations and strain diversity without the biohazard of culture. We searched PubMed, Web of Science, and Google Scholar, identifying…
Johnessa Cung, Patihul Husni, Kyung Taek Oh
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, hampered by prolonged, toxic treatment regimens that lead to poor patient adherence and drug resistance, as well as diagnostic tools that lack sensitivity and specificity. This systematic review evalu…
Sudarto Sudarto, Zen Hafy, Irsan Saleh, Iche Liberty, Zen Ahmad, et al.
Pulmonary tuberculosis (TB) remains a global health threat, with individual genetic determinants like Toll-like receptor 2 (TLR2) gene variations potentially modulating immune responses to. This systematic review evaluates the role of TLR2 polymorphisms in influencing susceptibil…
Shunli Cai, Qingyi Luo, Guozhong Zhou, Xin Guo, Yan Dong, et al.
…e Bacillus Calmette-Guérin (BCG) vaccine in preventing tuberculosis (TB) infection in children. **METHODS:** PubMed, Web of Science, Cochrane, and Embase were searched from their inception to January 12, 2025. Studies were included if they focused on children under 19 years…
Kindie Fentahun Muchie, Frank Tobian, Mary Gaeddert, Claudia Maria Denkinger, Johanna Kellett Wright, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major global health challenge, with an estimated 10.8 million new cases and 1.25 million deaths in 2023. Despite advances in molecular detection of Mycobacterium TB (MTB), significant diagnostic gaps remain: in 2023, onl…
Syed Hassan Ali, Shanza Shakir, Umais Ahmed Shaikh, Maryam Khalid, Maria Jawed, et al.
Tuberculosis (TB) remains a leading global cause of death. While primary Bacillus Calmette-Guérin (BCG) vaccination offers protection in children, the role of BCG revaccination in adults remains unclear. This study evaluated the efficacy, immunogenicity, and safety of BCG re…
Xuling Chang, Zheng Li, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thuy Thuong Thuong, et al.
**BACKGROUND:** Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very li…
TianYu Lin, Sheng Liu, Yan-Yu Pan
**BACKGROUND:** Tuberculosis (TB) remains a leading global cause of infectious mortality. Accelerating vaccine development requires validated immune correlates of protection (CoPs). Mechanistic studies have long highlighted Th1 cytokines (IFN-γ, IL-2, TNF-α) as crucia…
Beatriz Barreto Duarte, Jerrold Ellner, Alicia D Wright, Mark Hatherill, Amita Gupta, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading infectious cause of death globally. While control strategies have traditionally prioritized symptomatic cases, growing evidence highlights the substantial burden of asymptomatic or subclinical TB, microbiologically confirmed dis…
Seyed Alireza Mortazavi, Nicole A Swartwood, Nanki Singh, Melike Hazal Can, Hening Cui, et al.
…D:** Urban and rural settings differ in key determinants of tuberculosis (TB) burden, including transmission dynamics, social and structural determinants, and healthcare access. However, understanding of urban and rural TB burden is limited, hindering implementation of public hea…
Zi-Ke Chen, Zhao Wu, Ting Ye, Chao-Yang Lin, Xu-Guang Guo
…xhibited high diagnostic efficiency in detecting lymph node tuberculosis (LNTB). However, different gold standards and types of LNTB specimens may impact Xpert's diagnostic accuracy. This meta-analysis compared the performance of Xpert MTB/RIF on fine needle aspiration (FNA) and …