Showing 101–125 of 151 documents
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Ana Beatriz Marques Valença, Diogo Henrique Mendes da Silva, Melisane Regina Lima Ferreira, Paula Daniella de Abreu, Rubia Laine de Paula Andrade-Gonçalves, et al.
to map the literature on the use of Rapid Molecular Tests in the diagnosis of tuberculosis in people experiencing homelessness. this is a scoping review guided by the Joanna Briggs Institute and the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for …
Xinru Xu, Yanyi Lei, Li Zheng
**INTRODUCTION:** Non-tuberculous mycobacteria (NTM) represent an emerging public health threat in China. Despite evidence of rising NTM prevalence and significant regional variation, comprehensive and up-to-date nationwide data on epidemiology, species distribution, and drug res…
Qi Wang, Xiao-Nan Wang, Xiao-Qun Liu, Long-Ge Zhao, Zi-Tong Jing, et al.
**BACKGROUND:** Bovine tuberculosis (bTB) is a zoonotic disease caused by members of the Mycobacterium tuberculosis complex (MTBC), with Mycobacterium bovis being the primary agent responsible for infections in cattle, posing a significant threat to the global dairy industry. Alt…
Hanie Sakhi, Maryam Meskini, Mojgan Sheikhpour
…mic surveillance, robust drug policy enforcement, and rapid diagnostics to maintain treatment effectiveness and curb the spread of resistance. Future research should focus on elucidating resistance mechanisms and developing novel therapeutic strategies.
Ninglu Weng, Amir Vosoughi, Parsa Mehraban Far, Sterling King, Imane Marrakchi, et al.
**PURPOSE:** Uveitis is commonly regarded as a disease of young and middle-aged adults, with new-onset cases in older individuals frequently attributed to masquerade syndromes, particularly of neoplastic origin. However, few studies have examined the epidemiology or clinical patt…
Bruno Enagnon Lokonon, Sèton Calmette Ariane Houetohossou, Bruno Amèdjiko Tchede, Richard B Yapi, Aurélie Cailleau, et al.
…illance, ecological risk modelling, and smartphone-assisted diagnostics, AI deployment remains constrained by limited computational infrastructure, inadequate digital connectivity, data-governance weaknesses, and shortages of AI-trained specialists. Conversely, expanding mobile c…
Mingyang Qin, Yanhua Wen, Shanshan Li, Song Li, Xuming Li, et al.
…r to TB. This work paves the way for novel microbiota-based diagnostics and ecologically informed therapies. **IMPORTANCE:** Pulmonary tuberculosis (PTB) remains a leading cause of global mortality, yet the ecological principles shaping its respiratory microbiome are poorly unde…
Sonia Menon, Anthony D Harries, Riitta A Dlodlo, Gisèle Badoum, Mohammed F Dogo, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major global health threat, particularly in low- and middle-income countries, with TB infection (TBI) serving as the primary source of TB disease. While HIV infection has long been recognised as a major risk factor for TB progression, t…
Tingting Li, Huanqing Liu, Qian Lei, Zhuhong You
**BACKGROUND:** Tuberculosis (TB) caused 1.23 million deaths in 2024, with accurate diagnosis hampered by population heterogeneity and limited biomarker generalizability. We developed an integrative framework combining multi-cohort transcriptomics and machine learning to identify…
Thilini Agampodi, Hwa Young Kim, Dilrukshi Menike, Digantha Aswaddumage, Madushika Sewwandi, et al.
… mortality. We identify key gaps, including deficiencies in diagnostics and screening for maternal conditions; research disparities; limited data availability; the absence of pregnancy-specific infectious disease surveillance in Sri Lanka; and shortcomings in classifying infectio…
Sudarto Sudarto, Zen Hafy, Irsan Saleh, Iche Liberty, Zen Ahmad, et al.
Pulmonary tuberculosis (TB) remains a global health threat, with individual genetic determinants like Toll-like receptor 2 (TLR2) gene variations potentially modulating immune responses to. This systematic review evaluates the role of TLR2 polymorphisms in influencing susceptibil…
Dhanajayan Govindan, Yuvaraj Krishnamoorthy, Marie Gilbert Majella, Monica Karunakaran
**BACKGROUND:** Gender influences health outcomes by affecting exposure to risk factors, healthcare access, and health-seeking behaviours. Yet, many studies fail to consider how these gendered experiences interact with other social factors, such as age, socioeconomic status, and …
Wiktoria Andryszkiewicz, Maksym Bodziony, Milena Chmielewska, Martyna Kowalczyk, Gabriela Rzońca, et al.
Delayed-type hypersensitivity (DTH) to(MTb) antigens is a crucial component of the cellular immune response presented during tuberculosis infection. This reaction is driven primarily by T lymphocytes, which recognize mycobacterial antigens and trigger a focused inflammatory casca…
Felix Bongomin, Ivaan Pitua, Phillip Ssekamatte, Diana Sitenda, Irene Andia-Biraro, et al.
**OBJECTIVES:** Enzyme-linked immunosorbent assay (ELISA)-based QuantiFERON-TB Gold Plus (QFT-Plus ELISA) testing is associated with manual variability and indeterminate results. The transition from QFT-Plus ELISA to chemiluminescent immunoassay (CLIA) for QuantiFERON-TB Gold Plu…
Nyimas Maida Shofa, Nurike Setiyari Mudjari, Rusdiyana Ekawati, Arianti Arianti, Annisa Zahra Mufida, et al.
…reening and isoniazid prophylaxis, revealing false-negative diagnostics and partial chemoprophylaxis protection. These findings highlight the need for region-specific frameworks integrating multimodal screening, targeted prophylaxis and ongoing clinical surveillance. Adalimumab r…
Ziyan Zhu, Xinxin Miao
**BACKGROUND:** Infectious diseases of the spine (IDS) cause structural destruction and abscess formation, requiring precise early diagnosis. While conventional culture methods show limited sensitivity and slow turnaround, metagenomic next-generation sequencing (mNGS) offers a pr…
Usha Nayak, Tejaswini Baral, Sonal Sekhar Miraj, Mohan K Manu, Muralidhar D Varma, et al.
**BACKGROUND:** Female genital tuberculosis (FGTB) continues to be a significant problem worldwide. Endometrial biopsy (EB) is the most effective sample for detecting FGTB. However, biopsy is invasive and causes unwarranted suffering. Furthermore, a few studies have investigated …
Farag A Bleiblo, Madiha W El-Awamie, Nariman A Elsharif, Muetaz M Feetouri, Ibtihag S Alogali, et al.
Libya, a conflict-affected North African country, has a fragile health system and poor surveillance, leaving it largely underrepresented in global estimates. Earlier Libyan reviews were descriptive, lacking breakpoint standardization, isolate-level pooling, or AMR-attributable mo…
Pablo Troop, Brenna Keam, Caroline Mullen, Julius Nyerere Odhiambo
**INTRODUCTION:** Tuberculosis (TB) is a notable public health issue in sub-Saharan Africa (SSA), disproportionately affecting vulnerable populations such as nomads. Their migratory lifestyles limit consistent access to TB diagnostic and treatment services, leading to delays in d…
Mamta Choudhary, Mamta, Pushpa
…high-burden settings such as India. Despite advancements in diagnostics and therapeutics, individuals affected by MDR/XDR-TB often endure significant psychosocial, economic, and systemic hardships that are insufficiently addressed in the current literature. While most studies on …
Ravindra Kumar Garg, Rajiv Garg, Akshaya Anand Agrawal, Sanjay Singhal, Raza Abbas Mahdi
Tuberculosis (TB) in pregnancies conceived via in vitro fertilization (IVF) presents unique diagnostic and management challenges, especially in TB-endemic regions. This systematic review synthesizes evidence on maternal and neonatal TB outcomes after IVF. We conducted a syst…
Kofi Afriyie Nyamekye, Eric Sampane-Donkor, Haruna Latif, Justice Moses K Aheto
…includes direct medical costs (hospitalization, medication, diagnostics), nonmedical costs (transportation, food, caregiving), and indirect costs (loss of productivity, long-term disability, and mortality). Despite numerous economic studies on these diseases, there is limited res…
Roméo Bujiriri Murhega, Yao Christian Hugues Dokponou, Férol Baudelaire Babatundé Gbenou, Laté Dzidoula Lawson, Raïssa Diaby, et al.
**BACKGROUND:** Spinal tuberculosis is the most common form of extra pulmonary tuberculosis. While cervical involvement, known as cervical Pott's disease, has traditionally been considered rare, its incidence is increasing. However, comprehensive data on its clinical presentation…
Linda Fantato, Maria Salobehaj, Jacopo Patrussi, Gaia Meoni, Alessia Vignoli, et al.
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical tool in metabolomics, but it is often hindered by the high cost and technical complexity of the machines, limiting its clinical and point-of-care applications. Recent advances in benchtop NMR technology have s…
André Amate Neto, Taylor Endrigo Toscano Olivo, Patrícia Mastroianni, Mariane Nunes de Nadai, Marcela Forgerini, et al.
**BACKGROUND:** Pleural tuberculosis is one of the most frequent extrapulmonary manifestations ofinfection and is characterized by a pronounced immune-mediated response with a low bacillary burden. Host genetic factors appear to play a central role in its immunopathogenesis. **M…