Showing 101–125 of 200 documents
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Syed Hassan Ahmed, Syed Shayaan Hassan, Laila Tul Qadar, Nathan Selsky, Maria Duharte, et al.
**INTRODUCTION:** Tuberculosis (TB), a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (PLHIV), accounted for 161,000 deaths among HIV-co-infected patients in 2023. Tuberculosis preventive therapy can play a detrimental role in r…
Jiankang Jiang, Siqi Zhang, Hui Wang, Lu Zhang, Zegeng Li, et al.
**BACKGROUND:** Despite therapeutic interventions, tuberculosis (TB) remains a persistent challenge. Combination therapy integrating Traditional Chinese Medicine (TCM) with conventional anti-TB medications demonstrates therapeutic benefits, necessitating a meta-analysis evaluatin…
Vijay Pratap, Astha Lalwani, Ankur Malhotra
Genital tuberculosis (female genital tuberculosis [FGTB]) continues to be an essential underdiagnosed cause of infertility and reproductive morbidity, most significantly in resource-limited settings. Diagnostic laparoscopy and hysteroscopy have become crucial for assessing suspec…
Zhi-Lin Han, Yu-Yang Zhang, Jian Li, Shan Gao, Wei Liu, et al.
**BACKGROUND:** Pulmonary tuberculosis (PTB) remains a global public health challenge, with 10.8 million new cases reported in 2023. Early diagnosis is crucial for controlling its spread, yet traditional sputum-based tests face limitations in turnaround time and resource availabi…
Unjali P Gujral, Peijue Huangfu, Amanuel A Kisho, Elizabeth S Limb, Dzigbordi Kamasa-Quashie, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major public health challenge, with 10.8 million people developing TB in 2023. Diabetes mellitus (DM) is associated with an increased risk of TB and adverse TB outcomes. The prevalence of DM is rising, especially in regions of the world…
Nisha Kumari, Shashi Bhushan Singh, Dewesh Kumar, Geetu Singh, Pravin Yannawar, et al.
Tuberculosis (TB) is a major global health challenge, particularly in polluted areas. The relationship between ambient particulate matter and TB risk remains unclear, making this systematic review and meta-analysis (SRMA) vital for assessing this link. This SRMA aimed to estimate…
Felipe T Lima, Ricardo C Castro, Francisco R Javier, Caroline Fontanari, Valdes R Bollela, et al.
During tuberculosis (TB), organ-specific immune responses and intracellular pathways play critical roles in disease progression and prognosis. Identifying genes that regulate these immune mechanisms remains a key challenge in improving TB management strategies. To investigate gen…
Timothy Hudson David Culasino Carandang, Dianne Jaula Cunanan, Gail S Co, John David Pilapil, Juan Ignacio Garcia, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) infection, remains a significant public health threat. The timeliness, portability, and capacity of nanopore sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial…
Jenifer A Otieno, Lisa Malesi Were, Vittoria Lutje, Katie Scandrett, Yemisi Takwoingi, et al.
… as Xpert MTB/RIF Ultra, as the initial diagnostic test for tuberculosis (TB). However, the effect of these tests on key health outcomes is not well-established. **OBJECTIVES:** To assess the effects of three classes of rapid NAATs-low-complexity automated (LC-aNAATs), low-compl…
Chuan-Chin Huang, Alicia E Madden, Mercedes C Becerra, Roger Calderon, Alexander L Chu, et al.
…** Household-based studies are commonly used to investigate tuberculosis (TB) transmission and evaluate preventive interventions. These studies typically assume that household contacts (HHCs) who develop TB disease were infected by the identified index patient. However, community…
Clément Conil, Jonathan Bohlen, Elouise E Kroon, Marc A Jean-Juste, Jérémy Manry, et al.
**BACKGROUND:** Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals-so-called resisters-have persistently negative results for the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs). "Resistance to immune conversion" is the best-kn…
Bhavani Perumal Kannabiran, Jayanthi Arthanari, Adhin Bhaskar, Mukesh Kumar Sathya Narayanan, Leeberk Raja Inbaraj
… safety of high-dose rifampicin (>15 mg/kg) containing anti-tuberculosis regimen compared to a regimen with standard dose of rifampicin in adults with pulmonary tuberculosis. Methods We searched for studies from MEDLINE, Embase, Web of Science, Google Scholar, and the Cochrane Li…
Sarah Althomali
…on of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special population, not only postpones the start of appropriate treatment but also increases the risk of poor clinical o…
Zohreh-Al-Sadat Ghoreshi, Mohammad Ali-Hassanzadeh, Habibeh Mashayekhi-Sardoo, Hedyeh Askarpour, Nasir Arefinia
…*BACKGROUND:** Rapid and precise detection of Mycobacterium tuberculosis (MTB) is essential for effective management and control of tuberculosis. The diagnostic challenge is particularly acute for extrapulmonary TB, which accounts for approximately 15-20% of cases and often prese…
Neha Kumari, Ravindra Kumar, Ishan K Patro, Aparup Das
Mycobacterium tuberculosis (M.tuberculosis) continues to cause one of the most pressing health burdens in the world, especially in developing nations, in the form of tuberculosis (TB). In addition to socio-environmental factors, it is widely believed that host genetic factor…
Ika Nindya Kadariswantiningsih, Roy Novri Ramadhan, Derren David Christian Homenta Rampengan
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a significant public health issue in Indonesia, a country with a high tuberculosis burden. EPTB accounts for 15%-20% of global TB cases, with the proportion rising in populations co-infected with HIV. In Indonesia, estimates o…
Guocan Yu, Xudong Xu, Yanqin Shen, Yuyang Ling
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a serious type of tuberculosis (TB) which can cause systemic clinical manifestations. Rapid diagnosis of EPTB for intervention is of great importance. Nanopore sequencing as a third-generation gene sequencing method is a new k…
Garrett R Beeler Asay, Kai H Young, Tempest D Hill, Gibril J Njie
Contact investigation is a fundamental component of tuberculosis (TB) programs that drives prompt diagnosis and treatment of Mycobacterium tuberculosis infection among those exposed. Few studies have examined contact investigation costs for TB. We conducted a systematic review of…
Valentina L Sabella-Jiménez, Vanessa Sabella-Jiménez, Andrés Felipe Estupinan-Bohorquez, Jorge Acosta-Reyes
**INTRODUCTION:** Tuberculosis is the leading cause of death globally from a single infectious agent. Early diagnosis is critical to reducing morbimortality. In cases of negative smear microscopy or limited sputum production, bronchoalveolar lavage (BAL) samples offer an alternat…
Valerie Josephine Dirjayanto, Kieran Pasha Ivan Sini, Aureilia Calista Zahra, Pandya Praharsa, Muhammad Afif Vargas Pramono, et al.
**BACKGROUND:** Tuberculosis is a high-burden infectious disease requiring long-term treatment. Compliance is the key to cure; however, directly observed therapy (DOTS) is not always feasible. Telemedicine use in DOTS offers improved accessibility; however, its effectiveness has …
Xinyang Hu, Zhiwei Wu, Jing Lei, Yanqin Zhu, Jingtao Gao
**BACKGROUND:** Drug-resistant tuberculosis (TB) remains a major global public health challenge. While bedaquiline (BDQ) offers improved treatment outcomes for patients with multi-drug resistant TB (MDR-TB), its widespread use has led to the emergence of BDQ resistance. **METHOD…
Oumar Abakar Mahamed, Noussissy Sandokane Hounnoukon, Soraya Laraqui Houssaini, Imane El Faziki, Meryeme Kirat, et al.
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) is a constraining challenge for tuberculosis (TB) control worldwide. The Middle East and North African (MENA) region represents a significant part of the global MDR-TB burden. **AIM:** To estimate the pooled prevalence of…
Ida A A Parwitha, Vania D Djunaidy, Sofa D Alfian, Hari Setyowibowo, Ivan S Pradipta
Despite its importance in global TB elimination, tuberculosis preventive treatment (TPT) remains underutilized. Psychosocial barriers significantly contribute to this issue. This systematic review aims primarily to synthesize psychosocial interventions to improve the initiation o…
Ashish Satav, Dhananjay Raje, Vibhawari Dani, Radha Munje, Shraddha Kumbhare, et al.
…ribal communities in India experience a very high burden of tuberculosis (TB), estimated at 7030 per million. The diagnosis and notification gaps are substantial, partly due to the geographical remoteness of these populations. Within an overarching study to design an intervention…
Alveron Andreas Tear, Rafly Mochamad Rivaldo, Amaylia Oehadian, Chevie Wirawan, Guntur Darmawan, et al.
**BACKGROUND:** Tuberculosis (TB) is one of the most common infectious diseases in patients with systemic lupus erythematosus (SLE) and often has severe and devastating manifestations. This study aimed to systematically investigate the association between organ involvement and la…