Showing 76–100 of 200 documents
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Syed Hassan Ahmed, Syed Shayaan Hassan, Laila Tul Qadar, Nathan Selsky, Maria Duharte, et al.
**INTRODUCTION:** Tuberculosis (TB), a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (PLHIV), accounted for 161,000 deaths among HIV-co-infected patients in 2023. Tuberculosis preventive therapy can play a detrimental role in r…
Chuan-Chin Huang, Alicia E Madden, Mercedes C Becerra, Roger Calderon, Alexander L Chu, et al.
…** Household-based studies are commonly used to investigate tuberculosis (TB) transmission and evaluate preventive interventions. These studies typically assume that household contacts (HHCs) who develop TB disease were infected by the identified index patient. However, community…
Valentina L Sabella-Jiménez, Vanessa Sabella-Jiménez, Andrés Felipe Estupinan-Bohorquez, Jorge Acosta-Reyes
**INTRODUCTION:** Tuberculosis is the leading cause of death globally from a single infectious agent. Early diagnosis is critical to reducing morbimortality. In cases of negative smear microscopy or limited sputum production, bronchoalveolar lavage (BAL) samples offer an alternat…
Neha Kumari, Ravindra Kumar, Ishan K Patro, Aparup Das
Mycobacterium tuberculosis (M.tuberculosis) continues to cause one of the most pressing health burdens in the world, especially in developing nations, in the form of tuberculosis (TB). In addition to socio-environmental factors, it is widely believed that host genetic factor…
Sarah Althomali
…on of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special population, not only postpones the start of appropriate treatment but also increases the risk of poor clinical o…
Bhavani Perumal Kannabiran, Jayanthi Arthanari, Adhin Bhaskar, Mukesh Kumar Sathya Narayanan, Leeberk Raja Inbaraj
… safety of high-dose rifampicin (>15 mg/kg) containing anti-tuberculosis regimen compared to a regimen with standard dose of rifampicin in adults with pulmonary tuberculosis. Methods We searched for studies from MEDLINE, Embase, Web of Science, Google Scholar, and the Cochrane Li…
Garrett R Beeler Asay, Kai H Young, Tempest D Hill, Gibril J Njie
Contact investigation is a fundamental component of tuberculosis (TB) programs that drives prompt diagnosis and treatment of Mycobacterium tuberculosis infection among those exposed. Few studies have examined contact investigation costs for TB. We conducted a systematic review of…
Valerie Josephine Dirjayanto, Kieran Pasha Ivan Sini, Aureilia Calista Zahra, Pandya Praharsa, Muhammad Afif Vargas Pramono, et al.
**BACKGROUND:** Tuberculosis is a high-burden infectious disease requiring long-term treatment. Compliance is the key to cure; however, directly observed therapy (DOTS) is not always feasible. Telemedicine use in DOTS offers improved accessibility; however, its effectiveness has …
Clément Conil, Jonathan Bohlen, Elouise E Kroon, Marc A Jean-Juste, Jérémy Manry, et al.
**BACKGROUND:** Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals-so-called resisters-have persistently negative results for the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs). "Resistance to immune conversion" is the best-kn…
Ashish Satav, Dhananjay Raje, Vibhawari Dani, Radha Munje, Shraddha Kumbhare, et al.
…ribal communities in India experience a very high burden of tuberculosis (TB), estimated at 7030 per million. The diagnosis and notification gaps are substantial, partly due to the geographical remoteness of these populations. Within an overarching study to design an intervention…
Pablo Troop, Brenna Keam, Caroline Mullen, Julius Nyerere Odhiambo
**INTRODUCTION:** Tuberculosis (TB) is a notable public health issue in sub-Saharan Africa (SSA), disproportionately affecting vulnerable populations such as nomads. Their migratory lifestyles limit consistent access to TB diagnostic and treatment services, leading to delays in d…
Sanjay Singhal, Ranganath Ganga, Pulkit Gupta, Aneeket Rastogi, Shilpi Arya, et al.
…easing use of Linezolid for the treatment of drug-resistant tuberculosis, concerns have emerged about serious adverse effects, including optic neuritis. **OBJECTIVES:** To systematically review available evidence on the incidence reported in the cohort, onset, linezolid doses an…
AbdulAzeez Lawal, Abimbola Hussein, Simon Tiberi, Heinke Kunst
**BACKGROUND:** Adherence to tuberculosis (TB) treatment is essential in improving treatment outcomes and reducing TB-related mortality. People living with HIV (PLWH) are at a higher risk of developing and dying from TB. This systematic review aims to identify barriers and enable…
Anuj Ajayababu, Martin Hoenigl, Animesh Ray
…ssically described in asthma and cystic fibrosis, pulmonary tuberculosis (PTB) with post-tubercular lung disease (PTLD) has been reported as a likely predisposing factor. It, however, has not been reviewed systematically, which we aimed to achieve in the current systematic review…
Hongfang Lu, Jingang Wang, Xinyu Song, Xiaoqi Xiong
…elationship between the MCP-1-2518A/G gene polymorphism and tuberculosis susceptibility in the Chinese population. The aim of this study was to investigate whether MCP-1-2518A/G polymorphism is associated with susceptibility to TB in Chinese. **METHOD:** Publications addressing …
M J Nasiri, D R Silva, F Rommasi, M M Zahmatkesh, Z Tajabadi, et al.
**INTRODUCTION AND OBJECTIVES:** Post-tuberculosis lung disease (PTLD), as other chronic respiratory disorders, may have infectious complications; some of them can be prevented with vaccinations. So far, no document has discussed the potential role of vaccination in PTLD. Therefo…
Fanghui Xie, Rong Yao, Li Liang, Chuntao Wu, Yinping Hu, et al.
… best evidence for medication adherence management in adult tuberculosis (TB) patients, providing an evidence-based foundation for optimizing clinical practice. **METHODS:** Evidence-based questions were formulated using the PIPOST model. Following the '6S' model, 19 Chinese and…
Alveron Andreas Tear, Rafly Mochamad Rivaldo, Amaylia Oehadian, Chevie Wirawan, Guntur Darmawan, et al.
**BACKGROUND:** Tuberculosis (TB) is one of the most common infectious diseases in patients with systemic lupus erythematosus (SLE) and often has severe and devastating manifestations. This study aimed to systematically investigate the association between organ involvement and la…
Abraham Tekola Gebremedhn, Kidist Bobosha, Yeabsira Alemu Fantaye, Melese Yeshambaw Teferi, Ziad El-Khatib, et al.
**BACKGROUND:** Post-tuberculosis lung disease (PTLD) is a major public health challenge in sub-Saharan Africa (SSA), where the burden of tuberculosis (TB) remains high. Only a few studies have reported the global burden of PTLD, and the associated factors of PTLD have been under…
Eliza Miranda Ramos, Carolina Braga Sisti, Sérgio Beltrão de Andrade Lima, Emerson Luiz Lima Araújo, Lúcia Dias da Silva Guerra, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a major public health problem in South America, disproportionately affecting vulnerable populations, such as the homeless population (HP). **OBJECTIVE:** To synthesize, through a systematic review with meta-synthesis, the scientific ev…
Jirarat Songsri, Jongkonnee Thanasai, Jitbanjong Tangpong, Anchalee Chittamma, Wiyada Kwanhian Klangbud
The early diagnosis of pulmonary tuberculosis (PTB) remains a global challenge. While serum adenosine deaminase (ADA) has been associated with tuberculosis-related immune activation, its consistency across different regions and laboratory methods remains unclear. This study aims …
Ashutosh N Aggarwal, Ritesh Agarwal, Sahajal Dhooria, Perumal K Bhavani, Kuruswamy T Prasad, et al.
Standard rifampicin doses used to treat pulmonary tuberculosis lie at the lower end of drug exposure-response curve. We evaluated if higher daily rifampicin doses result in greater efficacy or harm. We searched literature databases for randomized controlled trials comparing effic…
Gauri Shankar, Yusuf Akhter
…sets (GSE8732 and GSE84554) to elucidate Mycobacterium tuberculosis (Mtb)'s transcriptional response to iron limitation, a key host defense mechanism. The study identifies a core set of consistently differentially expressed genes (DEGs) critical for Mtb's survival …
Natthakan Chitpim, Panida Yoopetch, Jiraphun Jittikoon, Wanvisa Udomsinprasert, Kornkanok Bunwong, et al.
…says such as Xpert MTB/RIF and TB-LAMP accelerate pulmonary tuberculosis (TB) diagnosis but are more expensive than smear microscopy. This study provided an updated economic synthesis for presumptive adult pulmonary TB in high-burden settings, broadening the evidence from Xpert M…
Aboudou Habirou Kifouly, Orléanse Kouin, Géorcelin Alowanou, Obase Ngemani Bekindaka, Pierre Challaton, et al.
**INTRODUCTION:** Bovine tuberculosis (bTB), caused by, is a chronic zoonotic disease of major global importance, particularly in low- and middle-income countries where surveillance and control remain inadequate. **OBJECTIVES:** This systematic review and meta-analysis aimed to …