Showing 76–100 of 151 documents
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Akihiko Goto, Ishikawa Kentaro, Taisei Hirakawa, Kosaku Komiya
Pulmonary tuberculosis (TB) and nontuberculous mycobacterial pulmonary disease (NTM-PD) often present with similar clinical and radiological features, making accurate differentiation essential. This systematic review aimed to summarize diagnostic features that distinguish pulmona…
Sidhya Choudhary, George R Thompson, Martin Hoenigl, S Nagarathna, Arghadip Samaddar
…agnosis and varied outcomes emphasize the need for improved diagnostics, clinician awareness, and optimized antifungal treatment strategies.
Sanele Ngcobo, Edith Madela Mntla, Jonathan Shock, Murray Louw, Linda Mbonambi, et al.
…s transformative tools in HIV care, driving advancements in diagnostics, treatment monitoring and patient management. The present review aimed to systematically identify, map and synthesize studies on the use of AI methods across the HIV care continuum, including applications in …
Guocan Yu, Keying Du, Yanqin Shen, Yuyang Ling, Fangming Zhong
**INTRODUCTION:** Accessing samples from mediastinal and hilar lymph nodes is considerably more difficult, rendering the diagnosis of tuberculous mediastinal and hilar lymphadenopathy particularly challenging. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS…
Carla Florencia, Kevin Aprilio, Dian Ayu Eka Pitaloka, Rob E Aarnoutse, Ivan Surya Pradipta
… limitations. Capacity building, electronic referrals, free diagnostics, and incentives are key strategies to support PP involvement. Strengthening collaboration between the PP and TB program staff is essential for effective and sustainable referral processes.
Pubet Weeranawin, Tanawat Geeratragool, Wanruchada Katchamart, Julajak Limsrivilai
**BACKGROUND/AIMS:** Diagnosis of intestinal tuberculosis (ITB) is challenging. Histopathology and microbiological examination remain the gold standard, but previous studies show varied diagnostic performance. We aimed to systematically evaluate the accuracy of tests to diagnose …
Tom Liba, Amit Olami, Michael Brant, Alon Gorenshtein, Adir Sommer, et al.
Pediatric uveitis is a leading cause of visual impairment, often resulting in severe complications without timely and appropriate intervention. Its etiology varies geographically, necessitating a comprehensive epidemiological assessment. To identify prevalent causes of pediatric …
Dominik Zenner, Hassan Haghparast-Bidgoli, Tahreem Chaudhry, Ibrahim Abubakar, Frank Cobelens
**BACKGROUND:** Optimising tuberculosis disease testing algorithms is fundamental to ensuring the effectiveness and cost-effectiveness of migrant screening programmes, including better understanding of individual and combined screening test properties. The aim of our study was to…
Md Mayin Uddin Hasan, Mohammad Injamul Hoq, Saifur R Chowdhury
**BACKGROUND:** Tuberculosis remains one of the primary infectious diseases in Bangladesh that affects both adults and children. Poor diagnostic criteria and insufficient reporting, especially of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in children, lim…
Carl Boodman, Nitin Gupta, Cansu Cimen, Johan van Griensven, Matthew P Cheng, et al.
…ndings highlight the potential of high-throughput molecular diagnostics to enhance infectious disease control, particularly in resource-limited settings.
Olivia Alise D'Silva, Samantha Lancione, Oviya Ananthakrishnan, Angelina Addae, Suvesh Shrestha, et al.
Eliminating the burden of catastrophic costs experienced by individuals undergoing tuberculosis (TB) treatment is one of the World Health Organization (WHO) End TB Strategy targets. To help inform decisions on TB patient burden and cost-effective TB care, we conducted a systemati…
Valentina Camarda, Robert F Miller
**OBJECTIVES:** To evaluate the incidence, management, and outcomes of Acute Respiratory Distress Syndrome (ARDS) in Sub-Saharan Africa (SSA), and to identify challenges related to healthcare infrastructure and resource availability. **DESIGN:** Systematic review of published st…
Sarah Althomali
**INTRODUCTION:** Timely diagnosis and prompt initiation of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special population, not only postpones the start of appropriate tr…
Matthew Willis, Joelle Van de Wetering, Heynes Brown, Ewelina Julia Barnowska, Sophie Cw Stuetzle, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) is a significant public health concern in India, contributing to 28% of the global pediatric TB burden. Despite its impact on child health, strategies to control TB have inadequately addressed pediatric cases, resulting in suboptimal ma…
Mikashmi Kohli, Leeberk Raja Inbaraj, Angela Salomon, Katie Scandrett, Alexei Korobitsyn, et al.
**BACKGROUND:** Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests widely used for simultaneous detection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum.…
Anuj Ajayababu, Martin Hoenigl, Animesh Ray
**INTRODUCTION:** Although allergic bronchopulmonary aspergillosis (ABPA) is classically described in asthma and cystic fibrosis, pulmonary tuberculosis (PTB) with post-tubercular lung disease (PTLD) has been reported as a likely predisposing factor. It, however, has not been rev…
Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, et al.
**BACKGROUND:** In 2023, an estimated 1.3 million children (aged 0-14 years) became ill with tuberculosis, and 166,000 children (aged 0-15 years) died from the disease. Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic t…
Anita Dalal, Gajendra Singh, Akhil K Gupta, Naresh Kumar Kakker, Sonu Kumari
…s, it also holds promise for advancing vaccine development, diagnostics, and targeted immunotherapy in veterinary practice. The shared role of IL-17A in veterinary and human health highlights the need of a One Health approach, acknowledging the interdependence of human, animal an…
Valentina L Sabella-Jiménez, Vanessa Sabella-Jiménez, Andrés Felipe Estupinan-Bohorquez, Jorge Acosta-Reyes
**INTRODUCTION:** Tuberculosis is the leading cause of death globally from a single infectious agent. Early diagnosis is critical to reducing morbimortality. In cases of negative smear microscopy or limited sputum production, bronchoalveolar lavage (BAL) samples offer an alternat…
Alice Bai, Hari Dandapani, Amrita Dosanjh
**PURPOSE:** The prevalence of pulmonary nontuberculous mycobacteria (NTM) infection and disease is increasing globally. Pediatric studies on treatment of pulmonary NTM disease in immunocompetent infants are limited, and adult guidelines lack details regarding age-specific manage…
Felix Bongomin, Aayush Adhikari, Ronald Olum, Pratik Baral, Iriagbonse Iyabo Osaigbovo, et al.
**BACKGROUND:** Human cystic echinococcosis frequently involves the lungs, and colonization of a residual cavity withspores can lead to chronic pulmonary aspergillosis (CPA). **OBJECTIVES:** We pooled and characterized cases of CPA co-existing with pulmonary cystic echinococcosi…
Monica Mbabazi, David Patrick Kateete, Faith Nakazzi, Joanitah Nabwire Wandera, Naume Mutesi, et al.
…. While Koch’s single-agent model has long guided TB diagnostics and treatment, metagenomic studies reveal a resident lung microbiome disrupted by TB and its orally administered therapy, with downstream effects on the gut microbiome. Understanding these disruptions may unc…
Deresse Daka, Belay Tessema, Awelani Mutshembele, Amir Alelign, Wubet Birhan, et al.
…ups and diagnostic tools, emphasizing the need for enhanced diagnostics and continuous surveillance to improve patient outcomes and inform public health strategies. **CONCLUSION:** The review summarizes the epidemiology and geographical distribution of NTM infections and common …
Agata Gierlotka, Ryszard Sordyl, Ireneusz Bielecki, Marek Mandera
**PURPOSE:** This review aims to identify and evaluate the management options for pituitary tuberculosis in the pediatric population. **METHODS:** The study was conducted based on a comprehensive literature review using the PubMed, Cochrane Library, and ScienceDirect electronic …
Cesar Copaja-Corzo, Dayana Ticona-Tiña, Brenda Caira-Chuquineyra, Daniel Fernandez-Guzman
**INTRODUCTION:** Fever of unknown origin (FUO) in people living with HIV presents a significant diagnostic challenge due to its broad range of potential aetiologies. **OBJECTIVE:** The aims of this study were to evaluate the prevalence of different aetiologies causing FUO in pe…