Showing 51–75 of 200 documents
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Yihenew Sewale Bizu, Kassahun Dires Ayenew
Tuberculosis (TB) remains a leading global infectious cause of illness and death, despite being preventable and curable, with the highest burden in low- and middle-income countries, particularly in Southeast Asia and Africa. TB is closely linked with mental health, as psychologic…
William J Burman, M Florencia Martins, David Flynn, James Johnston, Pranay Sinha, et al.
…t-related adverse events are one of the leading barriers to tuberculosis treatment completion but have not been the focus of late-phase clinical trials. We performed a scoping review to identify interventions to improve the safety and tolerability of rifampin-susceptible tubercul…
Omayma Benbrik, Oumaima Bounar, Imad Chakri, Laila Lahlou, Hind Serhane
**BACKGROUND:** Tuberculosis (TB) remains a major public health challenge. Treatment success rate (TSR) is a key indicator for TB control, yet national level evidence on treatment outcomes in Morocco is fragmented. This systematic review and meta-analysis aimed to estimate pooled…
Vidya Ganji, Bhushan Kamble, Farzana Mustafa, Naveen Ravi, U Madhusudhan, et al.
**INTRODUCTION:** Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major public health concern globally ranking as the second leading infectious disease and the 13th leading cause of death worldwide. The global healthcare systems have experienced unprecedented c…
Yulan Yang, Qiaolin Yu, Xia Zhao, Rong Yao, Jing Shen, et al.
…nts' illness experiences and needs are central to pulmonary tuberculosis management and have important implications for treatment engagement and health outcomes. This study addresses this gap by systematically synthesizing qualitative evidence to provide a comprehensive understan…
George N Okoli, Benjamin J Cowling, Nicole Askin, Diane M Harper, Paul Van Caeseele
**INTRODUCTION:** To thoroughly examine the risk of active tuberculosis and herpes zoster infections with tumor necrosis factor (TNF) inhibitor treatment in adults (≥18-year-olds) with autoimmune disease conditions. **METHODS:** A trial sequential analysis (TSA) informed …
Cristina Cioti, Irina Tica, Miruna Cristian Gherase-Cristian, Gabriela Fricatel, Oana Cristina Arghir
**BACKGROUND:** Tuberculosis (TB) has long been suspected to contribute to lung carcinogenesis through chronic inflammation and immune dysregulation. However, contemporary controlled evidence quantifying this association remains limited. We aimed to systematically evaluate the re…
Mohammad Yousef Alikhani, Fatemeh Khoobbakht, Salman Khazaei, Tahere Etesamifard, Sima Kazemi
…tic variant and an individual's susceptibility to pulmonary tuberculosis (TB). Nevertheless, the evidence from various studies is contradictory and has not yielded a consensus. This meta-analysis was therefore conducted to systematically assess the relationship between this speci…
Neha Sylvia Walter, Varun Gorki, Bikash Medhi, Pramod K Avti
…efficacy, and structure-activity mechanisms of AMPs against tuberculosis and malaria, the world's leading killer infectious diseases, employing the AMP database (APD3) (till June 2025) and PubMed search (January 1965 to June 2025). The comprehension is well addressed by covering …
Behailu Taye, Haile Tesfaye, Gemechu Churiso
…pid, accurate, and non-sputum point-of-care (PoC) assay for tuberculosis (TB), especially for people with HIV (PLHIV). The Fujifilm SILVAMP TB LAM (FujiLAM), a urine lipoarabinomannan assay, has shown promise for diagnosing TB in PLHIV. But diagnostic performances were inconsiste…
Vrunda Tavkar, Ankita Goyal, Vishal Chopra, Kranti Garg, Siddharth Sharma
**BACKGROUND:** Anti-tuberculosis drug-induced liver injury (AT-DILI) is one of the significant adverse effects of first-line tuberculosis therapy, frequently resulting in treatment discontinuation. Genetic polymorphisms in N-acetyltransferase 2 (), a key enzyme in the metabolism…
Ana Beatriz Marques Valença, Diogo Henrique Mendes da Silva, Melisane Regina Lima Ferreira, Paula Daniella de Abreu, Rubia Laine de Paula Andrade-Gonçalves, et al.
…ure on the use of Rapid Molecular Tests in the diagnosis of tuberculosis in people experiencing homelessness. this is a scoping review guided by the Joanna Briggs Institute and the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. A…
Xianni Wei, Ruina Cai, Xiaohong Wu, Yonglong Su, Siheng Lian, et al.
**PURPOSE:** Antituberculosis drug-induced liver injury (ATLI) is a common and serious adverse drug reaction of tuberculosis treatment. The impact of ATLI in patients with chronic hepatitis C is unclear. The aim of this study is to evaluate the prevalence of DILI in patients with…
Daniel Souza Sacramento, Samantha Adiely Alecrim Mendonça, Altair Seabra de Farias, Vanderson Sampaio
Digital solutions are essential for eliminating tuberculosis as a public health problem. They can be applied across all stages of patient care, health surveillance, program management, workforce development, and community engagement. In this study, we aimed to identify and map di…
Mingyang Qin, Yanhua Wen, Shanshan Li, Song Li, Xuming Li, et al.
**UNLABELLED:** Tuberculosis (TB) remains a major global health challenge. The close relationship between the microbiome and the host is becoming increasingly notable. While studies on the respiratory microbiome in pulmonary tuberculosis (PTB) exist, a comprehensive understanding…
Claudia Susana Pérez Guerrero, Tiago Augusto Cavalcante Oliveira, Willie Otávio Bueno Bernardi, Stephanie Ribeiro, Jeanne-Marie Stacciarini, et al.
**BACKGROUND:** Tuberculosis is an infectious, preventable and treatable disease that is socially determined. People experiencing homelessness represent a group that is highly vulnerable to this disease, presenting a challenge for its control and elimination. The aim of this revi…
Aleka Aemiro, Abayeneh Girma, Getachew Alamnie, Demsew Beletew, Amere Genet
…erable to opportunistic bacterial infections, which include tuberculosis and pneumonia. This systematic review and meta-analysis looked at the pooled prevalence of opportunistic bacterial infections among people living with HIV in different regions of Ethiopia. **METHODS:** By l…
Fernanda Souza, Ricardo Steffen, Marcia Pinto, Thiago Nascimento do Prado, Afranio Lineu Kritski, et al.
…:** The World Health Organization has recommended three new tuberculosis (TB) antigen-based skin tests (TBST) (Diaskintest®, C-TST®, Cy-TB®) for the diagnosis of tuberculosis infection (TBI). Household contacts (HHC) of people with pulmonary TB are at increased ris…
Jiankang Jiang, Siqi Zhang, Hui Wang, Lu Zhang, Zegeng Li, et al.
**BACKGROUND:** Despite therapeutic interventions, tuberculosis (TB) remains a persistent challenge. Combination therapy integrating Traditional Chinese Medicine (TCM) with conventional anti-TB medications demonstrates therapeutic benefits, necessitating a meta-analysis evaluatin…
Zhi-Lin Han, Yu-Yang Zhang, Jian Li, Shan Gao, Wei Liu, et al.
**BACKGROUND:** Pulmonary tuberculosis (PTB) remains a global public health challenge, with 10.8 million new cases reported in 2023. Early diagnosis is crucial for controlling its spread, yet traditional sputum-based tests face limitations in turnaround time and resource availabi…
Vijay Pratap, Astha Lalwani, Ankur Malhotra
Genital tuberculosis (female genital tuberculosis [FGTB]) continues to be an essential underdiagnosed cause of infertility and reproductive morbidity, most significantly in resource-limited settings. Diagnostic laparoscopy and hysteroscopy have become crucial for assessing suspec…
Nisha Kumari, Shashi Bhushan Singh, Dewesh Kumar, Geetu Singh, Pravin Yannawar, et al.
Tuberculosis (TB) is a major global health challenge, particularly in polluted areas. The relationship between ambient particulate matter and TB risk remains unclear, making this systematic review and meta-analysis (SRMA) vital for assessing this link. This SRMA aimed to estimate…
Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) remains a formidable public health challenge, posing a significant threat to human life and health security. Comprehensive comparative evidence on the efficacy and safety of various DR-TB treatment strategies remains limited. Th…
Siddique Sehrish, Xue-Tong Liu, Wen-Bo Lou, Shu-Ying Zhang, Emad Beshir Ata, et al.
**BACKGROUND:** Bovine tuberculosis (bTB) primarily caused by, is a globally prevalent zoonotic infectious disease of cattle and other livestock and wildlife species. Pakistan is the fourth-largest milk-producing country in the world, with approximately 212 million animals. Lives…
Beatriz Bernava Sarinho, Inajara Rotta, Tácio de Mendonça Lima, Brígida Dias Fernandes, Patricia Melo Aguiar, et al.
…eutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness, and safety of different regimens. …