Showing 26–45 of 45 documents
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Mayu Hikone, Yuya Kondo, Yu Takaizumi, Wataru Kagaya, Katharina Kranzer, et al.
**INTRODUCTION:** Current diagnostics for tuberculosis (TB) rely on sputum or site-specific specimen collection, posing critical limitations in certain populations. Urine has emerged as an alternative specimen, as demonstrated by urine lipoarabinomannan (LAM) testing. Beyond LAM,…
Benjamin Freitag, Ayten Sultanli, Maurizio Grilli, Stefan Fabian Weber, Mary Gaeddert, et al.
**BACKGROUND:** Clinical diagnosis of tuberculosis (TB), referring to diagnosis without bacteriological confirmation, is common and may affect an individuals' outcomes. We undertook a systematic review to assess the proportion of people with TB who were diagnosed clinically, and …
Liwei Yao, Caifang Bu, Lijun Xiang
…ulous lymphadenitis (TL) is a common case of extrapulmonary tuberculosis caused by Mycobacterium tuberculosis (MTB). The current use of nanopore sequencing in TL is limited. The aim of our study is to complete a systematic review and meta-analysis protocol to assess the performan…
Joseph Donovan, Fiona V Cresswell, Elizabeth W Tucker, Angharad G Davis, Ursula K Rohlwink, et al.
Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal management. Therefore, the Tuberculous Meningitis International Research Consortium …
Rajesh Verma, Rajarshi Chakraborty
Tuberculous meningitis (TBM) is a critical form of tuberculosis with high morbidity and mortality. Paradoxical reactions (PR) are frequently observed in neurotuberculosis, with diverse manifestations. A selective immune dys/upregulation leads to cytokine surge. The exact immune p…
Fang Li, Yi Zhou, Jingsi Tan, Zifei Meng, Laifa Wang, et al.
…ngitis (TBM) remains a highly lethal form of extrapulmonary tuberculosis. Aspirin, owing to its anti-inflammatory and antithrombotic properties, has been explored as adjunctive therapy, but its clinical benefits remain controversial. This meta-analysis aimed to evaluate the effic…
Rogers Kamulegeya, Rose Nabatanzi, Derrick Semugenze, Faridah Mugala, Mercy Takuwa, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, and treatment failure contributes to ongoing transmission, drug resistance, and poor clinical outcomes. Artificial intelligence and machine learning approaches have attracted grow…
J V Ashwin, Rajesh Verma, Mohit Kumar Shahi, Bhupendra Singh, Akash Arjun Kamble
Tuberculous Meningitis (TBM) is one of the severe forms of tuberculosis affecting the central nervous system, often leading to long-term cognitive impairment. Understanding these deficits is essential for improving treatment outcomes and guiding rehabilitation strategies. A syste…
Guocan Yu, Keying Du, Yanqin Shen, Yuyang Ling, Fangming Zhong
…e diagnostic accuracy for both pulmonary and extrapulmonary tuberculosis; its accuracy in diagnosing tuberculous mediastinal and hilar lymphadenopathy using EBUS-TBNA specimens has not yet been systematically evaluated. **METHODS AND ANALYSIS:** Adhering to Preferred Reporting I…
Andressa Lorena Ieque, Carolina Trevisolli Palomo, Deborah de Castro Moreira, Jean Eduardo Meneguello, Letícia Sayuri Murase, et al.
…eningitis (TBM) is one of the most severe clinical forms of tuberculosis (TB). Since epidemiological studies can contribute to TB control, we conducted a review and meta-analysis of epidemiological publications of adults TBM cases in countries with high incidence of TB.The search…
Abayeneh Girma, Fentaye Kassawmar, Yeshiwas Kassa, Yeshwas Asrat
Worldwide, tuberculosis (TB) ranks as a second leading cause of death. The End TB strategy targets eliminating TB by 2030. Achieving this goal requires an early, accurate, and affordable diagnosis applicable in low- and middle-income countries; increasing the reach of point-of-ca…
Mengyu Luan, Xiaoyou Chen
… reduce the incidence of tuberculoma and other extracranial tuberculosis; prednisolone might increase the risk of neurological events [OR (95% CrI) = 5.98 (2.03, 20.7)], while standard-dose rifampicin was less likely to cause neurological events [OR (95% CrI) = 0.25 (0.06, 0.78)]…
Juliet G Nyamasve, Nyaradzai A Katena, Shepherd Shamu, Junior Mutsvangwa, Aliasgar Esmail
**INTRODUCTION:** Extrapulmonary tuberculosis (EPTB) poses a significant diagnostic and economic challenge in HIV endemic, low-resource settings due to its complex presentation and current diagnostic tools limitations. While accurate and timely diagnosis is critical for reducing …
Andrea Llamas-Lopez, James A Seddon, Felicia C Chow, Caryn M Upton, Sanjay K Jain, et al.
… Tuberculous meningitis (TBM) remains the deadliest form of tuberculosis. Inadequate penetration of rifampicin and ethambutol into the brain and cerebrospinal fluid (CSF) may contribute to mortality. Over the last decade, research has focused on "intensified" treatment (higher-do…
Samin Afazel, Mohammad J Nasiri, Vishwanath Venketaraman
… meta-analysis aim to assess the treatment outcomes of anti-tuberculosis drugs in TBM patients, focusing on mortality and neurological disability. **METHODS:** We conducted a comprehensive literature search on PubMed/MEDLINE, EMBASE, and Cochrane CENTRAL databases to identify ar…
Elizabeth Teo, Karon Kung, Sarah Chen, Kay C See
…meningitis (TBM) is a severe extrapulmonary complication of tuberculosis. Early diagnosis is crucial in improving patient outcomes, albeit difficult given the non-specific clinical presentation of early stage TBM. Numerical diagnostic scoring systems may be useful diagnostic tool…
Abisola R Isaiah, Monray Williams, Du Toit Loots, Aurelia A Williams, Novel N Chegou, et al.
**UNLABELLED:** Tuberculosis (TB) is the leading cause of death from a single infectious agent, with approximately 1.2 million deaths reported in 2023. While TB primarily affects the lungs, it can also spread to other organs, where it is classified as extrapulmonary TB. Tube…
Nima Eftekhari, Maryam Gholizadeh, Zahra Azizi, Saeid Najafi, Reza Mohammadi, et al.
… meningitis (TBM) is the most severe form of extrapulmonary tuberculosis, frequently complicated by cranial nerve palsy (CNP) and ophthalmic nerve palsy (ONP), which are associated with poor prognosis. Understanding their incidence and associated risk factors is essential for tim…
Walter Fagundes, Aisha R Ahmed, Yasmin P Silva, Paweł Łajczak, Helvécio N Feitosa Filho, et al.
**OBJECTIVE:** Endoscopic third ventriculostomy (ETV) is advocated as a shunt-free alternative for managing hydrocephalus to mitigate the complications associated with ventriculoperitoneal shunt (VPS). However, its efficacy in treating pediatric tuberculous meningitis-related hyd…
Jiaqi Pu, Shouquan Wu, Jian-Qing He
**INTRODUCTION:** The efficacy and safety of high-dose rifampicin in patients with tuberculous meningitis (TBM) remain uncertain. **METHOD:** A comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Database was conducted to identify randomized contro…