Showing 1–25 of 200 documents
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Soraya Permata Sujana, Fadilah Habibul Hamda, Mufti As Siddiq, Yuniko Ibnu Latif, Al Asyary
**BACKGROUND:** Tuberculosis is one of the leading causes of death from infectious diseases in the world, with approximately 25% of the global population having latent tuberculosis infection. Secondhand smoke exposure has been recognised as a significant risk factor in the develo…
Md Mayin Uddin Hasan, Mohammad Injamul Hoq, Saifur R Chowdhury
**BACKGROUND:** Tuberculosis remains one of the primary infectious diseases in Bangladesh that affects both adults and children. Poor diagnostic criteria and insufficient reporting, especially of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in children, lim…
Laura Olbrich, Leyla Larsson, Rory Dunbar, Peter J Dodd, Megan Palmer, et al.
…* In 2023, almost 200,000 children under 15 years died from tuberculosis, most without appropriate treatment. Treatment decision algorithms (TDAs), developed to facilitate rapid anti-tuberculosis treatment initiation in children, were recommended by the World Health Organization …
Peter Scott, Maysa Elsayedkarar, Edson Marambire, Gertrude Ncube, Tsitsi Apollo, et al.
**BACKGROUND:** Tuberculosis household contacts are at elevated risk of HIV, and systematic screening for tuberculosis is an opportunity for people to know their status. We aimed to assess the coverage and positivity of HIV testing during household systematic screening for tuberc…
M Deepaselvi, C Ammaiyappan Palaniswamy, Santhi Sree Mummadisingu, Sai Chandhan Throvagunta, Kavatarapu Pradyumna, et al.
…nufacturing. Silicosis not only increases susceptibility to tuberculosis (TB) infection but also adversely impacts TB outcomes. Despite the long-established association between silicosis and TB, a clear understanding of the burden within the Indian context has remained unexplored…
Cornelius Gweba, Adegboyega Omoniyi Oyefabi, Abimbola Awopeju, Regina Doro Jabaka, Leonard Ighodalo Uzairue
**INTRODUCTION:** The emergence of multidrug-resistant tuberculosis has eroded the gains made in the fight against tuberculosis. This review aims to provide current perspectives on the lineages of thecomplex (MTBC) associated with drug-resistant tuberculosis (DR-TB) in Africa. *…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Abraham Tekola Gebremedhn, Kidist Bobosha, Hawult Taye Adane, Yeabsira Alemu Fantaye, Dawit Girma Abebe, et al.
**BACKGROUND:** Post-tuberculosis lung disease (PTLD) is a significant global public health challenge. The contribution PTLD on long-term morbidity and impaired quality of life is increasingly recognized. There is limited evidence on effective management strategies of PTLD. This …
Helen Zhang, Naomi Medina-Jaudes, Alicia Forcada-Nadal, Ewan M Harrison, Francesc Coll
**BACKGROUND:** Tuberculosis (TB) is the leading cause of death from an infectious disease worldwide. Mutations arising in Mycobacterium tuberculosis complex (MTBC) strains during TB infection provide a record of bacterial adaptations, such as those needed to survive the attack o…
Harri Hardi, Zahra Fitrianti, Liganda Endo Mahata, Melva Louisa
… complicated therapeutic challenges, such as the coinfected Tuberculosis (TB)-HIV population. This systematic review analyses pharmacogenes related to antiretroviral and anti-tuberculosis medications in the TB-HIV population. An analysis of 39 included studies indicated that efav…
Maham Zahid, Saima Afaq, Kashif Shafique, Fatima Khalid Qazi, Urooj Ashfaq, et al.
**INTRODUCTION:** Tuberculosis (TB) and diabetes mellitus comorbidity can lead to poor TB treatment outcomes, particularly with uncontrolled blood glucose levels. Understanding the impact of glycemic control on TB treatment outcomes is essential. **OBJECTIVE:** To synthesise evi…
Rebecca Thomas, Nicola L Harman, Paula R Williamson, Laura Bonnett, Geraint R Davies, et al.
**BACKGROUND:** The global burden of tuberculosis (TB) remains high, and treatment of both drug-susceptible and drug-resistant diseases is complex and prolonged. International clinical trial networks and public-private partnerships are beginning to deliver advances in TB treatmen…
Aninda Debnath, Ravindra Nath, Anubhav Mondal, Pankaj Chandrabhan Nathe, Jugal Kishore, et al.
Tuberculosis (TB) and tobacco use are two intertwined public health challenges that significantly impact low- and middle-income countries, particularly India, which bears the highest global TB burden. Tobacco use exacerbates TB risk, progression, and treatment outcomes. Despite t…
Janmejaya Samal, Hari Singh
**BACKGROUND:** Delayed tuberculosis (TB) care can have adverse effects on both patients and the community. Such delays can perpetuate transmission within the community and disrupt ongoing efforts to eliminate TB. **OBJECTIVES:** The primary objective of this meta-analysis was t…
Anna Juul Christensen, Laura Risbjerg Omann, Jessica Carlsson, Joseph Baruch Baluku, Ole Kirk, et al.
… substance and hazardous alcohol use in people with HIV and tuberculosis (TB) disease and its impact on TB treatment outcomes. **METHODS:** A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched MEDLI…
Alfred Ngwira, Samuel Manda, Esron Daniel Karimuribo, Sharadhuli Iddi Kimera
**BACKGROUND:** Tuberculosis (TB) in cattle negatively affects the cattle economy in Africa, with zoonotic TB posing drug-resistance issues in humans. The burden of TB in cattle and zoonotic TB in humans in sub-Saharan Africa (SSA) is not well understood. This study aimed to dete…
Dereje Dana Zeruma, Mesfin Kote, Eshetu Zerihun, Getahun Gedabo, Biruk Wogayehu
**INTRODUCTION:** The WHO’s 2024 Global tuberculosis (TB) Report shows that TB causes 1.25 million deaths annually, including 161,000 TB-Human Immunodeficiency Virus (HIV) infections. It affects 10.6 million people, mainly in Asia and Africa, 75% of whom are…
Abdulaziz S Aljibali
…GROUND:** Chest radiography is routinely used during latent tuberculosis infection (LTBI) evaluation to exclude active disease. **METHODS:** PubMed and google scholar were searched for studies reporting chest radiographic abnormalities among individuals with LTBI in Gulf Coopera…
Janmejaya Samal, G S Preetha, Hari Singh
**BACKGROUND:** Delayed diagnosis and treatment can be detrimental not only to patients but also to the community, as such delays can perpetuate TB transmission. This presents a significant challenge in the ongoing efforts to eliminate TB from the community. The primary objective…
Leeberk Raja Inbaraj, Mukesh Kumar Sathya Narayanan, Jefferson Daniel, Vignes Anand Srinivasalu, Adhin Bhaskar, et al.
**BACKGROUND:** Accurate and prompt diagnosis of tuberculosis in children is challenging due to non-specific clinical presentation and the low bacillary load of samples. Low-complexity manual nucleic acid amplification tests (LC-mNAATs) such as loop-mediated isothermal amplificat…
Alexander W Kay, Maia Madison, Katie Scandrett, Tara Ness, Pauline Amuge, et al.
…ated 1.3 million children (aged 0-14 years) became ill with tuberculosis, and 166,000 children (aged 0-15 years) died from the disease. Xpert MTB/RIF Ultra (Xpert Ultra) is a molecular World Health Organization (WHO)-recommended rapid diagnostic test that detects Mycobacterium tu…
David J Horne, Jerry S Zifodya, Adrienne E Shapiro, Elizabeth Chandler Church, Jonah S Kreniske, et al.
…commended rapid diagnostic test that simultaneously detects tuberculosis and rifampicin resistance. This review updates a comparative accuracy Cochrane review of Xpert MTB/RIF and Xpert Ultra as Xpert Ultra has replaced Xpert MTB/RIF. **OBJECTIVES:** To determine the diagnostic …
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…n tests, such as loop-mediated isothermal amplification for tuberculosis (TB-LAMP), are among the molecular WHO-recommended rapid diagnostics and can provide results within a few hours, even in resource-limited settings. We aimed to synthesise evidence on the accuracy of these te…
Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, et al.
…gnostic tests (also known as mWRDs) widely used to diagnose tuberculosis disease. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended by the WHO to assist in diagnosing tuberculosis disease amongst people with HIV. Previous systematic reviews have assessed the …
Hannah M Rickman, Mphatso D Phiri, Helena R A Feasey, Maria Krutikov, Hui Shao, et al.
**BACKGROUND:** Tuberculosis killed 1·25 million people globally in 2023. Men have a 1·7 times higher tuberculosis incidence than women, but it is not known to what extent this discrepancy is driven by greater exposure to Mycobacterium tuberculosis. We aimed to analyse …