Showing 1–25 of 200 documents
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Steven G Smith, Ruth Bowness, Jacqueline M Cliff
Host-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection. The growing type 2 diabet…
Angélica Moncada Morales, María Teresa Herrera Barrios
Tuberculosis (TB) is an infectious disease that represents a health problem in the world, with pulmonary tuberculosis (TBP) as the most frequent type of TB. This disease is caused by Mycobacterium tuberculosis (M. tuberculosis) that enters the host by inhalation. M. tuberculosis …
Richard G White, Gavin J Churchyard, Katherine C Horton, Andrew Fiore-Gartland, Marcel A Behr, et al.
Current licensure trials of new vaccines to prevent tuberculosis disease use bacteriologically confirmed symptomatic tuberculosis disease as the primary endpoint. Globally, the incidence of symptomatic tuberculosis disease is low, making licensure trials large, long, and expensiv…
Roger Kolamou, Boubacar Sidy Sily Bah, Siba Kalivogui, Boubacar Diallo, Alpha Arsida Barry
…e human immunodeficiency virus very often paves the way for tuberculosis. These two diseases form an association. The aim of this study was to carry out a retrospective study for the period 2018–2020 in order to determine the prevalence of tuberculosis and human immunodeficiency …
Rajita Bhavaraju, Bruno Andrade, Suzanne Siminski, Soyeon Kim, Mark Hatherill, et al.
**BACKGROUND:** Clinical tuberculosis (TB) research has been hampered by a lack of reliable predictors of Mycobacterium tuberculosis infection progression and active TB treatment's cure, relapse, and failure. Given host and bacterial variability, large sample sizes from harmonize…
Pooja Khandelwal, Neelam Yadav, Arzoo Saini, Neelam Singh Sangwan
Tuberculosis (TB) remains one of the most serious and deadly infectious diseases worldwide. Despite being preventable and curable, it is responsible for increasing the annual fatality by millions. The situation is even more alarming in the developing nations, where TB ranked in t…
Carlos Martín, Jesús Gonzalo-Asensio, Nacho Aguiló, Ainhoa Arbués
Despite major advances in diagnosis and treatment, tuberculosis (TB) control - and ultimately elimination - will remain unachieved without a vaccine capable of preventing pulmonary disease and transmission. Bacille Calmette-Guérin (BCG), a live attenuated vaccine derived fro…
Ryan Dinkele, Sophia Gessner, Andrea McKerry, Bryan Leonard, Ronnett Seldon, et al.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading infectious killer globally, claiming 1.4 million lives annually. TB control is heavily predicated on treatment of active disease. However, delayed and missed diagnoses, and the six-month du…
Radha Gopalaswamy, Gowsalya Saminathan, Vasudevan Manoharan, Siva Kumar Shanmugam
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is one of the oldest diseases known to humanity, with evidence of its existence dating back thousands of years. Despite the availability of effective treatments, TB causes morbidity and mortality globally, with special …
Muhammad Imran Qadir, Faryal Batool
Tuberculosis is a bacterial disease caused by Mycobacterium tuberculosis and can adversely affect the lungs and other parts of the body. It can be easily transmitted and can even cause death if not treated on time. In a report by WHO 10.4 million people were infected with TB in 2…
Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Tuberculosis (TB) remains the leading cause of death worldwide from a single infectious disease. An estimated quarter of the world's population, about 2 billion people, has an immune response to Mycobacterium tuberculosis (Mtb) without clinical, microbiological, or radiological s…
Emily Lai-Ho MacLean, Kyung Hyun Oh, Kalpeshsinh Rahevar, Carl-Michael Nathanson, Alexei Korobitsyn, et al.
**BACKGROUND:** Timely, accurate tuberculosis (TB) diagnostics and strong laboratory networks are critical for providing high-quality TB care. In the Western Pacific Region, available resources, TB burdens, and access to TB testing vary dramatically between countries. To understa…
Kyung Hyun Oh, Alvin Kuo Jing Teo, Manami Yanagawa, Avinash Kanchar, Dennis Falzon, et al.
**BACKGROUND:** Tuberculosis preventive treatment (TPT) can avert progression from infection to disease, yet scale-up across the World Health Organization Western Pacific Region is patchy. To guide acceleration, we assessed progress, challenges and responses in seven high-burden …
Kohei Kamegai, Ikumi Ono, Sayaka Kageyama, Kotaro Murata, Shunta Miura, et al.
In December 2024, Japan's Pre-Entry Tuberculosis Screening (JPETS) program was introduced in coordination with the Ministry of Health, Labour and Welfare (MHLW), the Ministry of Foreign Affairs, and the Immigration Services Agency to mandate tuberculosis (TB) screening for mid- t…
Susanna Esposito, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, with children representing a particularly vulnerable population in whom diagnosis is often challenging. Pediatric TB is typically paucibacillary and presents with non-specific clinical manifestations,…
María Belén Vecchione, Denise Anabella Giannone, Milagros Victoria Acevedo, Natalia Santucci, Maria Florencia Quiroga
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of mortality worldwide among infectious agents, and HIV increases the risk of developing into active disease. HIV-TB coinfection impairs immune responses, while chronic inflammation and infection-associated stress activate…
Salvatore Rotundo, Francesca Serapide, Gabriella d'Ettorre, Maria Teresa Tassone, Mattia Albanese, et al.
Tuberculosis (TB) remains a significant global health challenge, especially in countries with low TB incidence, exacerbated by the influx of migrants from high TB-burden regions. This paper reviews the challenges and strategies for managing TB infection (TBI) among migrants. Chal…
Yonathan William, Marto Sugiono, Patricia Diana Prasetiyo, Adelbertus Erico, Gilbert Sterling Octavius
…d tuberculous prostatitis. The patient was treated with antituberculosis drugs, resulting in symptomatic improvement and a significant PSA decline. This case highlights the diagnostic challenge of distinguishing tuberculous prostatitis from prostate cancer, particularly in tuberc…
Phumeza Tisile, Goodman Makanda
<bold>Meaningful partnerships that put TB survivors and people living with TB at the centre of research and policy-making are critical to the elimination of TB</bold> <ext-link>https://bit.ly/ERSM101intro</ext-link>
Aishwarya Venkataraman, Nancy Hilda Joseph, Gopika Sadanandan, S Balasubramanian
Clinical research involving children presents significant challenges due to physiological, ethical, regulatory, and practical considerations unique to this vulnerable population. These intrinsic challenges were amplified during the COVID-19 pandemic, which substantially disrupted…
Xinxin Fan, Muxing Chen, Di Wu, Youfei Lin, Xiaohong Chen
According to the 2024 World Health Organization (WHO)Global Tuberculosis (TB)Report, tuberculosis remains the leading cause of death from a single infectious agent, with 10.8 million new cases and 1.25 million deaths in 2023. Early and standardized treatment upon definitive diagn…
Yusup Subagio Sutanto, Magdalena Sutanto, Agnes Sri Harti, Nony Puspawati
This study highlights the sensitivity of Mycobacterium tuberculosis isolates from suspect tuberculosis patients to seromucous of snail and chitosan as an alternative to anti-tuberculosis drugs. This research is based on the results of laboratory experiments. The research stages i…
Ravi Talapa, Nidhi Yadav, Siddhant Jain, Tanvi Sirohi, Shourya Yerramareddy
Tuberculosis is a disease with widespread character and a long treatment process. Tuberculosis affecting the thyroid gland is a rare occurrence, even in the regions where tuberculosis is prevalent. This case report details the presentation of a 22-year-old male who initially pres…
Yu Lan, Isabel Rancu, Melanie H Chitwood, Benjamin Sobkowiak, Kate Nyhan, et al.
Tuberculosis remains a leading cause of infection-related mortality, and efforts to reduce its incidence have been hindered by an incomplete understanding of local Mycobacterium tuberculosis transmission dynamics. Advances in pathogen sequencing and spatial analysis have created …
Lindsay H. Cameron, Jeffrey R. Starke
Childhood tuberculosis differs from adult tuberculosis in epidemiology, clinical and radiographic presentation, and treatment. The risk of a child developing tuberculosis is influenced by age, immune status, and the intensity of exposure to a source case with tuberculosis disease…