Showing 1–13 of 13 documents
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Pooja Semwal, Manjit Kaur Saini, Moinak Sen Sarma
…atotoxicity (ATDIH) is a significant concern while managing pediatric tuberculosis. There is limited data on pediatric ATDIH, and much of the management practices are extrapolated from adult experiences. This article provides a comprehensive overview of the incidence, risk factor…
Jammula Mounika
…0% of childhood TB mortality. This case report focuses on a pediatric patient with obstructive hydrocephalus secondary to tubercular meningitis, complicated by pyrazinamide-induced hepatitis. The elevated dosages of essential antituberculosis agents for pediatric use, recommended…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…mong children worldwide, with approximately one million new pediatric cases annually. The conventional treatment for drug-susceptible TB has long relied on a 6-month multidrug regimen, which is highly effective but associated with challenges in adherence, toxicity, and healthcare…
Olga Adriana Căliman-Sturdza
…eic-acid diagnostics for cerebrospinal fluid (CSF), refined pediatric regimens, and emerging intensified/adjunctive treatments. Narrative synthesis of current guidelines and peer-reviewed articles (priority on 2019–2025), with an emphasis on pathophysiology, diagnostics, treatmen…
Hien Thi Thu Nguyen, Tuong Khanh Bui-Nguyen, Chi Que Nguyen, Hanh Thi My Dinh, Trang Khanh Tran, et al.
…itive, time-consuming, and impractical in extrapulmonary or pediatric TB and in individuals unable to produce sputum. Metabolomics has emerged as a promising approach for identifying host-derived biomarkers that reflect treatment-associated immunometabolic changes; however, the a…
Rafael Laniado-Laborín
Traditionally little attention has been paid to pediatric tuberculosis by clinicians, researchers, decision-makers, and even by national tuberculosis programs. According to the World Health Organization (WHO) Global Report for the year 2018, 10 million people developed TB in 2017…
Kerry L Hilligan, Patricia A Darrah, Robert A Seder, Alan Sher
…n regimens confer limited protection outside the context of pediatric extrapulmonary tuberculosis (TB), promising new data indicate that when administered mucosally or intravenously at a higher dose, BCG can induce sterilizing immunity against pulmonary TB in nonhuman primates. B…
Fabiana Cristina Fulco Santos, André Luiz Alves do Nascimento, Laís Ariane de Siqueira Lira, Juliana Figueirêdo da Costa Lima, Rosana de Albuquerque Montenegro, et al.
… that helps on patient prognosis. It should be a concern of pediatricians when they come across chronic cases of back pain and arthralgia in endemic areas.
Shayam Kaushik, Savita Krishnamurthy, Neelam Grover, Rajni Kaushik
The study's goal is to examine the range of adolescents tuberculosis. Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a known fact since the early 20th century. Most of the world's adolescents live in low-income and middle-income countries…
Şule Kızıltaş, Aylin Babalık
TB is a major cause of human deaths worldwide and the leading cause of death due to an infectious disease after COVID-19 [1]. TB is caused by the bacillus Mycobacterium tuberculosis which is spread from one person to another through the air. M. tuberculosis is estimated to infect…
Dhara Gosai, Jigar B. Gosai, Omprakash Shital Shukla
Background: Tuberculosis is the world's second leading cause of death from an infectious disease, being second only to AIDS. There is a lack of good data on the prevalence of all types of tuberculosis among children in India; most surveys have focused on pulmonary tuberculosis. T…
Andrea Migliorelli, Marianna Manuelli, Andrea Ciorba, Francesco Stomeo, Stefano Pelucchi, et al.
Tuberculosis (TB) continues to be the foremost cause of mortality from infectious diseases on a global scale, with laryngeal tuberculosis (LTB) constituting a rare, yet clinically significant form of extrapulmonary TB. Despite accounting for less than 1% of total TB cases, LTB is…
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Irina Dovgalyuk, Anastasia Kulpina, et al.
Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette and Camille Guérin, has a history sp…