Showing 1–10 of 10 documents
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Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…outcomes, especially in children, due to delayed diagnosis, drug resistance, and limited diagnostic techniques. **METHODS:** This review provides a comprehensive overview of recent advancements in TBM management and treatment. A systematic search was performed across major datab…
Venus Marie R Rojas, Michaela Zwyer, Selim Bouaouina, Daniela Brites, Sonia Borrell, et al.
…ly widespread and have been repeatedly associated with multidrug resistance. By comparison, MTBC L1 has received little attention, partially because of its restricted geographical range that mainly includes low- to middle-income countries in South and Southeast Asia, and East Afr…
Olga Adriana Căliman-Sturdza
…ith an emphasis on pathophysiology, diagnostics, treatment (drug-susceptible and drug-resistant TBM), and age-specific issues. Xpert MTB/RIF or Xpert Ultra should be the first-line CSF tests in adults and children with suspected TBM; the latter has greater sensitivity in paucibac…
Rong Li, Rong Yin, Yuanming Li, Yaxuan Wei, Bin Zhao, et al.
…effect of the blood-brain barrier against anti-tuberculosis drugs and the issue of drug resistance, treatment outcomes are often suboptimal. Furthermore, current early sensitive diagnostic tools are inadequate, leading to delayed treatment for many patients and adversely affectin…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…ew pediatric cases annually. The conventional treatment for drug-susceptible TB has long relied on a 6-month multidrug regimen, which is highly effective but associated with challenges in adherence, toxicity, and healthcare burden.To evaluate whether short-course therapy is an ap…
Rafael Laniado-Laborı́n
… disease than the general population. Many antituberculosis drugs are hepatotoxic. If aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are increased more than three times the upper limit of normal in the presence of symptoms of hepatitis or >5 times the upper l…
Rajender Kumar, Apurva Sood, Anish Bhattacharya
…propriate biopsy site, evaluating disease extent, detecting drug resistance, and monitoring treatment response. The following chapter aims at understanding the various features of nuclear medicine molecular imaging that can be used in the management of spinal TB.
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Irina Dovgalyuk, Anastasia Kulpina, et al.
…from TB remains urgent, especially in regions burdened with drug-resistant TB, highlighting the need for robust protective measures.
Promod K Mehta, Jefry Sebastian
…s have been deliberated to diagnose TB (including EPTB) and drug resistance (DR), i.e. in-house PCR/multiplex-PCR, commercial real-time PCR (e.g. Cobas TaqMan/LightCycler), line probe assay (e.g. GenoType MTBDRplus), GeneXpert®/GeneXpert® Ultra and Truenat®MTB/MTB …
Qi Dong, Miaoran Wang, Zhaohua Wang, Jie Shi, Jianping Xie, et al.
The incidence of tuberculosis (TB) and non-tuberculous mycobacteria (NTM) diseases and the number of deaths from these diseases are steadily increasing worldwide. However, the pathologic diagnosis of NTM disease is similar to that of tuberculosis, and it is often difficult to dis…