Showing 1–17 of 17 documents
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Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
The reported poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require a…
Agata Maciejak-Jastrzębska, Grażyna Sygitowicz, Sylwia Brzezińska, Kinga Bielska, Ewa Augustynowicz-Kopeć
…h rate, both of which significantly prolong microbiological diagnostics. Due to the mortality rate and the rising prevalence of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), early detection and prompt initiation of treatment are extremely impo…
Shahista, Jappreet Kaur, Amit Kumar Singh, Vivek Kumar Garg
Drug-resistant tuberculosis (DR-TB) is described as tuberculosis that is not responding to one or more anti-TB medications. A person is diagnosed with DR-TB if they do not respond to regular TB treatment; then a more challenging treatment regimen and a longer treatment duration a…
Xin Mao, Jingkai Wang, Junchi Xu, Ping Xu, Huijie Hu, et al.
…oscopy, culture-based methods, antigen detection, molecular diagnostics (including nucleic acid amplification tests and whole-genome sequencing), spectroscopic techniques (such as Raman spectroscopy), and mass spectrometry-based approaches. Notably, this review focuses on pathoge…
Kenneth W Foreman, Hui-Chen Foreman
…a broadly effective vaccine, limited sensitivity of current diagnostics, particularly for paucibacillary and extrapulmonary TB, and significant adverse effects associated with prolonged small-molecule drug regimens. The growing prevalence of multidrug-resistant (MDR) and extensiv…
Sonia Menon, Kobto Ghislain Koura
… AI-driven predictions in national TB programmes to enhance diagnostics, track trends, and strengthen public health surveillance. While promising for reducing transmission and supporting TB care in low-resource settings, these models require large-scale validation to ensure real-…
Pauline Howell, Jonathan Stillo, Anja Reuter, Tendai Nkomo, Carole D Mitnick, et al.
Drug-resistant tuberculosis is entering a new and dangerous phase. Bedaquiline and other newer drugs have transformed drug-resistant tuberculosis treatment, yet resistance to these agents is now being reported across high-burden settings. In some regions, baseline bedaquiline res…
Ted Lankester
… methods of case finding and case holding, existing and new diagnostics, and the treatment of adults and children. It explains the categories for recording cases and of treatment outcomes. It outlines the community and clinic background to managing cases of multidrug-resistant (M…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Tuberculosis (TB) remains one of the world's most urgent public health challenges, with a substantial global burden that continues to affect millions annually. According to the World Health Organization (WHO) Global Tuberculosis Report 2024, approximately 10.6 million people deve…
Vinay Jasani, Ahmed Abdelaal, Mohamed Mohamed
Since the inception of the first antituberculous chemotherapeutic agent, drug resistance has been one of the most challenging problems facing the global fight to control tuberculosis. Drug resistance to antituberculous chemotherapy is a spectrum which includes mono-drug resistanc…
Biniam Paulos, Daniel Bisrat, Maramawit Yonathan Yeshak, Kaleab Asres
Tuberculosis (TB), an infection caused by, affects nearly one-third of the world's population. It is estimated that TB infects around ten million people worldwide, with no less than two million fatalities annually. It is one of the treatable infections due to improved diagnostic …
Koushik Mukherjee, Pritam Saha, Kirat Kumar Ganguly, Somjyoti Chakraborty, Swarnali Ghosh, et al.
…losis (Mtb), is a global health threat. Despite advances in diagnostics and treatment regimens, it infects millions annually. It remains a significant global health challenge, particularly due to the appearance of resistance towards anti-tuberculosis drugs (ATD), mainly multidrug…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
…ictive markers for fluoroquinolones resistance in molecular diagnostics. The present study aimed to analyze the treatment outcomes and risk factors associated with fluoroquinolone drug resistance due to mutations in the gyrA and gyrB genes. A total of 258 pulmonary tuberculosis (…
Vaishnavi Vivekanandan, Arun K, Sindhu Hasini Doredla, Harini Ramanujam, Ranjani Singaraj, et al.
…mans has not been observed yet. Enhancing routine molecular diagnostics is vital for precise MTBC differentiation and a better grasp of cross-species transmission dynamics. A unified One Health strategy, which combines human, animal, and environmental monitoring, is essential to …
Ariel Torres, Gisselle Trujillo, José Daniel Sánchez
Drug-resistant tuberculosis (DR-TB) represents a major public health threat, particularly in the prisons of Latin America and the Caribbean, where rates are up to 40 times higher than those observed in the general population. These facilities act as community amplifiers due to ov…
Maciej Michalik, Tomasz Lorenc, Krzysztof Marcinkowski, Mateusz Muras, Natalia Mikszta, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant global health threat, particularly in low- and middle-income countries with limited access to quality healthcare. By 2023, 10% of global tuberculosis cases were classified as drug-resistant, with multidrug-resistant (MDR-TB)…
Emranul Kabir, Mahbub Alam, Md Ismail Haque
Tuberculosis (TB) treatments rely on novel compounds, improved delivery, and combination therapies, but challenges like toxicities, drug resistance, HIV incompatibility, and lack of knowledge about drug processes persist. TB remains one of the most prevalent infectious diseases g…