Showing 1–20 of 20 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Gregor Nosan, Andreja Cerkvenik Škafar
…s to modernize TB prevention while awaiting next-generation vaccines and may serve as a guide for other low-incidence countries.
Huimin Chen, Ye Gu, Lei Song, Lihui Si
…bacterial infections has exacerbated the need for effective vaccines to prevent these hard-to-treat pathogens. Traditional vaccine approaches have achieved tremendous successes but often fall short for pathogens like(TB), which evades host immunity through complex mechanisms, and…
Sandip Patil, Indu Singh, Indira Kumari Verma, Anil Kumar, Juhi Sharma, et al.
…ttracted the attention of scientific communities to revisit vaccines as a potential candidate against these superbugs. Although vaccines dedicated to bacterial infections are substantially reducing antibiotic use and decreasing annual healthcare expenditures for drug-resistant in…
Ayman Elbehiry, Eman Marzouk, Husam M Edrees, Riyad AlShaqi, Abousree T Ellethy, et al.
…the Xpert MTB/RIF Ultra, BPaLM regimen, and next-generation vaccines such as M72/AS01E represent pivotal progress, their deployment remains uneven. Implementation science, cost-effectiveness analyses, and health equity considerations are vital to scaling up these tools. Moreover,…
Jesús Gonzalo‐Asensio, Nacho Aguiló, Dessislava Marinova, Carlos Martı́n
Tuberculosis (TB) is the biggest killer of humanity. TB has killed more human beings than any other infectious disease in history, with an estimated loss of over a billion lives in the past 200 years (1). Despite effective treatment, in the WHO 2016 there were an estimated 10.4 m…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Gloria Guillermina Guerrero Manríquez
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTb). TB causes mortality of millions of people every year. Mycobacterium bovis Bacillus Calmette Güerin (BCG) is the only officially approved vaccine that protects against miliary TB and children bu…
Vincent J. C. van Winden, Edith N. G. Houben, Miriam Braunstein
…is and physiology to advance the development of new anti-TB vaccines and antibiotics.
Mareike Rabe, Jennifer A Hughes
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a major public health concern in South Africa (SA), with children, adolescents, and pregnant and postpartum women (CAPPW) facing heightened risks because of biological and social vulnerabilities. This article high…
Sarman Singh, Arti Shrivas
…Newer drugs and treatment regimens have been introduced and vaccines are in the pipeline. Despite these advances and opportunities, a precise, affordable, and accessible diagnostic model is yet to be evolved, especially in rural and difficult-to-reach areas, where the most desira…
Christian W. McMillen
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, emerged in Africa about seventy thousand years ago. It accompanied modern humans on their migrations out of Africa, across the Indian Ocean, and then into Eurasia. Tuberculosis affects almost all parts of the body. Its …
Benson Olu Akinshipe, Anthony Chukwuka Nwaobi, Emmanuel Babatunde Adedeji, Friday Alfred Ehiaghe, Herbert Obi Okpala
Host immune response against Mycobacterium tuberculosis (MTb) is mediated by cellular immunity in which cytokines and MTb-specific T cells play an important role. The detection of MTb and discrimination between different states of MTb infection is possible by immunodiagnostic tes…
Rafael Laniado-Laborín
One-third of the world's population is infected with M. tuberculosis. It is from this vast pool of infected people where the new cases of active disease originate. Most of these cases of latent infection are found in low-income countries where national tuberculosis programs conce…
Shweta Tiwari, Ankit Kumar Singh, Aarshu Acharya, Joyabroto Ghosh, Rashmi Prabha Singh
…ycobacterium tuberculosis (MTB). Despite the development of vaccines and antibiotics to cure the disease, it remains a major global problem due to the development of several ingenious pathogenic pathways. This comprehensive review introduces the mechanisms of bacterial pathogenes…
Selvamano Selvaraj, Jayaprakash N S
Tuberculosis (TB) is a highly infectious disease caused by. The World Health Organization (WHO) has reported more than 8 million new or relapse TB cases and 1.25 million deaths in 2023. Even though the global End TB strategy implemented by WHO has reduced the TB incidence rate be…
Anna Starshinova, Adilya Sabirova, Igor Kudryavtsev, Artem Rubinstein, Arthur Aquino, et al.
Latent tuberculosis infection (LTBI) represents a biologically active yet clinically asymptomatic stage of(Mtb) persistence. This condition is characterized by subtle immunometabolic alterations reflecting the host-pathogen equilibrium. Understanding the mechanisms and biomarkers…
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, et al.
…ogenicity mechanisms of Mtb will aid the development of new vaccines and anti-tuberculosis drugs. In this review, we summarize the latest research progress on Mtb virulence factors to provide a reference for targeted TB treatment.
Gerald Mboowa
Drug-resistantremains a significant global public health threat. While whole-genome sequencing (WGS) holds immense promise for understanding transmission dynamics and drug resistance mechanisms, its integration into routine surveillance remains limited. Additionally, insights fro…
Christopher Dye
Abstract Stable, familiar endemic infections are rarely seen as health emergencies, even though they kill millions of people each year. But there are ways to remedy the neglect, here illustrated by tuberculosis. Because curative treatment is currently the best form of prevention,…
Qiuyue Song, Junlin Liu, Chunhua Wang
Tuberculosis is a severe infectious disease caused by(MTB) infection and poses a serious public health challenge globally. The prevalence of multidrug-resistant MTB in countries with a high burden of tuberculosis has further increased the challenges of tuberculosis prevention and…