Showing 1–10 of 10 documents
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Buyun Xu, Mengjuan Yuan, Lisa Yang, Lan Huang, Jingxin Li, et al.
…e is an urgent need to develop more effective preventive TB vaccines. Currently, preventive TB vaccines under clinical investigation globally include live attenuated vaccines, recombinant subunit vaccines, viral vector vaccines, and mRNA vaccines. This article reviews and summari…
Angela Hidalgo-Gajardo, Bryan Mangui, Carla Villavicencio, Jorge R Toledo, Frank Camacho
…tes the host immune response used as a component in subunit vaccines, either alone or in combination with other antigens. Incorporating this protein into new diagnostic, therapeutic, and vaccine strategies could optimize disease control. This review explores HspX's multifaceted r…
Laura Mateu-Arrom, Lluis Puig
…general population, including annual influenza and COVID-19 vaccines. Live-attenuated vaccines are generally advised against in patients undergoing biologic treatment. However, some live-attenuated vaccines may be safely administered under specific circumstances with IL-17 or IL-…
Cynthia A. Bonville, Joseph B. Domachowske
… burden that this infection poses. Until safe and effective vaccines are available for the prevention of all forms of TB infection across all groups, the best control measures include early detection and treatment, programs to ensure adherence to treatment regimens, and comprehen…
Subhashree Barik, Pulak Pritam, Ayon Chakraborty, Sreelipta Das, Sakshi Priyadarsini Dutta, et al.
…Acr1 and Acr2 has been utilized for developing and boosting vaccines and as a diagnostic marker for active and latent TB. Some recent studies have also implicated the development of drugs against these small heat shock proteins. In addition, several structure-function studies est…
Lucía Madero, Iria Bastón, Eduard Brunet-Mas, Margalida Calafat, Grupo Joven de GETECCU
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, carries an increased risk of tuberculosis (TB), particularly in patients treated with immunosuppressive therapies such as anti-TNF agents. The risk is further elevated when combined with immu…
Aigul Utegenova, Lazzat Kassayeva, Bayan Turdalina, Aliya Baiduissenova, Ayaz Yktiyarov, et al.
Latent tuberculosis infection (LTBI) represents a major global health concern as it constitutes the principal reservoir for future tuberculosis (TB) disease. Its identification is particularly important in Bacille Calmette-Guérin (BCG)-vaccinated populations, where cross-rea…
Roxana Rustomjee
…cs and treatments for active and latent disease, preventive vaccines, and laboratory assays of disease progression, immune protection, and cure. This lack of progress is, in turn, related to a poor understanding of the fundamental relationship between Mycobacterium tuberculosis a…
Mariana Araújo-Pereira, Bruno B Andrade
Tuberculosis infection (TBI) affects approximately one quarter of the global population and constitutes the principal reservoir sustaining future cases of tuberculosis disease (TBD). Interferon-gamma release assays (IGRAs) have become central tools for identifying TBI, particular…
Peter Matuku-Kisaumbi
This chapter focuses on how biomarkers of tuberculosis can be utilized in the diagnosis, prognosis and treatment monitoring of TB. Tuberculosis biomarkers are measurable molecular indicators present and/or whose levels are altered in disease states. Found in blood, urine, broncho…