Showing 1–8 of 8 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Lidia Del Pozo-Ramos, Andreas Kupz
…ausing over a million deaths annually. The only licensed TB vaccine for human use, Bacille Calmette-Guérin (BCG), a mycobacteria-based live-attenuated vaccine, confers immunity to children but fails to efficiently protect adults from pulmonary TB. Several TB vaccine candidat…
Gabriela Sadigurschi, Maria Cristina Caetano Kuschnir, Ewerton Alves Portela Dos Santos, Bruno Rangel Antunes da Silva, Celia Menezes Cruz Marques, et al.
…den. Currently, the neonatal Bacillus Calmette-Guérin (BCG) is the only vaccine against TB and offers significant efficacy against disseminated and meningeal disease in children. However, BCG has a limited efficacy in preventing adult-type cavitary TB, reinforcing the need f…
Aishwarya Shaji, Akanksha Verma, Ashima Bhaskar, Ved Prakash Dwivedi
…den. To assist in curbing the spread of TB, the century-old BCG, which is a live-attenuated vaccine, is now the only licensed TB vaccine used in humans. However, BCG's limited efficacy and poor antigenicity in adults have evoked the need to design new vaccines against TB. The lim…
Sara Tengattini, Teodora Bavaro, Francesca Rinaldi, Caterina Temporini, Loredano Pollegioni, et al.
…erged. Immunization with the bacillus Calmette-Guérin (BCG) vaccine is one of the primary strategies to mitigate the risk of TB. Despite its widespread use, the current BCG vaccine has limited efficacy, particularly in adults. This review focuses on the rational design of va…
Alexa Giovanatti, Adrienne E Shapiro
…e leading infectious cause of death worldwide, yet the only vaccine currently available is the pediatric BCG, which has poor effectiveness in preventing TB in adolescents and adults. A TB vaccine for this older age group is projected to prevent 4.6-8.5 million deaths by 2050 and …
Joan Joseph-Munné, Milena Maya-Hoyos, Narcís Saubi, Santiago Perez, Miguel Angel Martinez Lopez, et al.
…Thus, the development of an effective, safe, and accessible vaccine for neonates and/or adults is an urgent need to prevent or control HIV infection or progression to AIDS. An effective HIV vaccine should induce long-lasting mucosal immunity, broadly neutralizing antibodies, inna…
Carlos Martín, Jesús Gonzalo-Asensio, Nacho Aguiló, Ainhoa Arbués
…d ultimately elimination - will remain unachieved without a vaccine capable of preventing pulmonary disease and transmission. Bacille Calmette-Guérin (BCG), a live attenuated vaccine derived from Mycobacterium bovis and the only licensed TB vaccine, has been widely implement…
Pere-Joan Cardona
Tuberculosis (TB) vaccine development is hindered by the absence of validated correlates of protection, the low proportion of infected individuals who progress to disease, and the pervasive impact of reinfection in endemic settings. Although several candidates have advanced clini…