Showing 126–150 of 200 documents
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Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…thogenesis but also informs the rational design of improved vaccines and therapeutic interventions aimed at ultimately controlling this ancient and devastating disease.
Anna Starshinova, Adilya Sabirova, Igor Kudryavtsev, Artem Rubinstein, Arthur Aquino, et al.
Latent tuberculosis infection (LTBI) represents a biologically active yet clinically asymptomatic stage of(Mtb) persistence. This condition is characterized by subtle immunometabolic alterations reflecting the host-pathogen equilibrium. Understanding the mechanisms and biomarkers…
Wenlong Qi, Lin Tian, Zhenyu Li, Jianan Xu, Tan Wang
Lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Opportunistic infections (OI) are increasingly recognized in this population due to disease-related immune dysfunction and treatment-induced immunosuppression. Compared with the chemoth…
Akshay Girish Manikoth, Brahmaji Sontyana, Rohini Shrivastava, Sudip Ghosh, Sangita Mukhopadhyay
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that employs several strategies to evade the host immune system to establish a favorable niche inside the macrophages. One of the major immune evasion strategies involves induction of T helper 2 (Th2)-type response, wh…
Mariona Cortacans, Nino Gogichadze, Pablo Soldevilla, Zoran Stojanovic, Onno Akkerman, et al.
This review brings together global data on bacterial, fungal, nontuberculous mycobacterial (NTM) and viral infections that complicate the course of individuals following the diagnosis of pulmonary or extrapulmonary tuberculosis (TB). It shows how residual structural lung damage (…
Selvamano Selvaraj, Jayaprakash N S
Tuberculosis (TB) is a highly infectious disease caused by. The World Health Organization (WHO) has reported more than 8 million new or relapse TB cases and 1.25 million deaths in 2023. Even though the global End TB strategy implemented by WHO has reduced the TB incidence rate be…
Samuel Keefer, Ana C Lorenzo-Leal, Horacio Bach
Nanotraps are particles designed to capture and concentrate target molecules and have numerous applications in infectious diseases. This review outlines how nanotrap technologies may improve the detection and treatment of bacterial and viral pathogens, including,,, HIV, SARS-CoV-…
Sudhasini Panda, Kendall Kearns, Cecilia S Lindestam Arlehamn
Effector T cells are central to immune defense against(), exerting complex and multifaceted roles that contribute to both protection and immunopathology. CD4T cells activate macrophages, maintain granulomas, and coordinate broad immune functions through diverse subsets, including…
Taru S Dutt, Robert Krause, David Hertz, Marcela Henao-Tamayo, Alasdair Leslie, et al.
B cells play a crucial role in immunity against various infectious diseases. However, their role in tuberculosis (TB) has been largely understudied. Emerging evidence suggests that B cells actively shape immune responses in TB. Beyond their classical functions, B cells contribute…
Aigul Utegenova, Lazzat Kassayeva, Bayan Turdalina, Aliya Baiduissenova, Ayaz Yktiyarov, et al.
Latent tuberculosis infection (LTBI) represents a major global health concern as it constitutes the principal reservoir for future tuberculosis (TB) disease. Its identification is particularly important in Bacille Calmette-Guérin (BCG)-vaccinated populations, where cross-rea…
Lu Lu Zhang, Jun Ping Peng
Tuberculosis (TB) continues to pose a significant threat to global public health, necessitating rapid and precise diagnostic methods and comprehensive detection of antimicrobial resistance (AMR) to facilitate timely clinical management. Traditional diagnostic techniques suffer fr…
Claire M Wagner, Amy Lin, Sabin Nsanzimana, Janet K Ginnard, Jayasree K Iyer, et al.
New health products have contributed to major improvements in public health, but many clinically effective interventions still face delays in reaching low- and middle-income countries (LMICs). Market shaping approaches have emerged as a set of tools designed to address such acces…
Fangzheng Guo, Yamin Song, Sihang Dong, Jing Wei, Baiqing Li, et al.
Tuberculosis (TB) is a chronic infectious disease caused by(Mtb) that poses a severe threat to human health. A variety of highly immunogenic tuberculosis proteins have been used as targets in vaccine development to mitigate the spread of TB. Although Th1-type immunity has long be…
Irene Agulló-Ros, Inmaculada Moreno-Iruela, Mercedes Domínguez, José Carlos Gómez-Villamandos, María A Risalde
Tuberculosis (TB) is a worldwide zoonotic disease caused by bacteria members of the Mycobacterium tuberculosis complex (MTC), which affects a wide range of domestic and wildlife species, as well as humans. TB is characterized as a chronic pulmonary infection, primarily affecting …
Amanda C Zangirolami, Aaron B Benjamin, Hatice Ceylan Koydemir, Wenshe R Liu, Jeffrey D Cirillo
…e a profound impact on progress toward new therapeutics and vaccines and allow rapid diagnosis. Although imaging can quantify bacterial loads throughout an entire animal in real-time, sensitivity is a key limitation. Fluorescent and bioluminescent recombinant strains have been us…
Ankush Dhillon, Prabhati Yadav, Saurabh Gupta, Shoor Vir Singh, Jagdip Singh Sohal, et al.
Paratuberculosis is a chronic ruminal-enteric infection caused by Mycobacterium avium subsp. paratuberculosis (MAP). It has significant economic, trade, and public health implications. In addition to evading host immunity, MAP modulates the gut microbiome, resulting in dysbiosis …
Ahmad Faris Daradkeh, Basil Alawyia, Hassan Ballas, Nikolaos Spernovasilis, Danny Alon-Ellenbogen
Tuberculosis continues to represent a major occupational risk in healthcare environments, particularly for healthcare workers who have persistent contact with patients who may be infectious. Despite the high occupational burden of tuberculosis among healthcare workers, there rema…
Farida Almarzooqi, Ahmed Aziz Bousfiha
Advances in genomic technologies, including whole exome and genome sequencing, have transformed diagnosis of monogenic disorders such as inborn errors of immunity (IEIs). In high-consanguinity populations like the United Arab Emirates (UAE), where autosomal recessive disorders ar…
Xinen Kong, Jiayi Yang, Jiajun Wang, Jiaxiang Li, Xiaoying Jin, et al.
…mmunodeficiency virus (HIV) co-infection, lack of effective vaccines and diagnosis methods, as well as the low treatment efficacy of anti-TB therapeutics lead to multiple difficulties and challenges in TB control. Host immune defense is critical for the processes and outcome of M…
Mohd Shariq, Javaid Ahmad Sheikh, Anwar Alam, Nasreen Z Ehtesham, Seyed E Hasnain
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health challenge, exacerbated by prolonged treatment regimens, variable vaccine efficacy, and the emergence of drug-resistant strains. Beyond conventional pathogen-targeted antibiotics, increasing att…
Karin Dijkman, Simone A Joosten, Leendert A Trouw
…ystem can be harnessed to improve tuberculosis diagnostics, vaccines and therapeutics.
Jessica Castañeda-Casimiro, Luis Vallejo-Castillo, Eliud S Peregrino, Alejandro Hernández-Solis, Luis Vázquez-Flores, et al.
Antibodies are produced by cells of the adaptive immune response and recognize epitopes of microbial structures with high affinity and specificity. Antibodies are recognized by Fc fragment receptors (FcRs) found on the surface of phagocytic cells (neutrophils, monocytes, macropha…
Huicong Liu, Haoran Li, Shanshan Li, Yuanyuan Shang, Shenjie Tang, et al.
…novel co-inhibitory receptor blockers and immune modulatory vaccines. This review presents a novel perspective on the application of targeting co-inhibitory receptors in tuberculosis treatment, which will advance the development and application of immunotherapy.
Omid Nikjeh, Seyedehparmis Rejali, Kayvan Sasaninia, Vishwanath Venketaraman
…uding interferon-γ, GM-CSF, and IL-7; and therapeutic vaccines (M72/AS01E, MTBVAC, VPM1002) as promising adjuncts. Distinct from guideline-focused overviews, this review emphasizes non-tuberculous mycobacterial disease (NTM, including MAC) and leprosy in PLWH and synthesize…
Saifur Rehman, Shakeeb Ullah, Kholik Kholik, Muhammad Munawaroh, Akhmad Sukri, et al.
Bovine brucellosis, a prevalent zoonotic disease, is caused by the bacterium, which can infect both humans and animals. This review article aims to provide a full explanation of the causes, historical background, occurrence, development, clinical manifestations, diagnosis, spread…