Showing 101–125 of 148 documents
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Yashna Sukdeo, Nozibusiso Pearl Shozi, Nonsikelelo Ndimande, Kingsley Chimaeze Mbara, Peter M O Owira
**AIMS:** Mycobacterium tuberculosis (MTB) uses epigenetics to avoid the hostile host immune defence systems and also mount resistance to chemotherapy when exposed to antibiotic stress. MTB's epigenetic survival tool-kit includes genomic DNA histone acetylation/deacetylation, met…
Nirjhar Saha, Mainak Chatterjee, Tejas M. Dhameliya, Asit K. Chakraborti
Tuberculosis (TB), a widespread infectious disease, has been a curse for humanity for many years. To cure this deadly disease, various medications are used in combination therapy. However, treatment of TB becomes problematic due to the appearance of drugresistant (DR), multidrug-…
Li Huang, Hao Li
…on-small cell lung cancer (NSCLC), yet patients with active tuberculosis (TB) are consistently excluded from clinical trials. Furthermore, data guiding the use of dual PD-1/CTLA-4 blockade in the presence of multidrug-resistant TB (MDR-TB) is lacking. We report a 56-year-old man …
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Ayman Elbehiry, Eman Marzouk, Husam M Edrees, Riyad AlShaqi, Abousree T Ellethy, et al.
Tuberculosis (TB) remains one of the leading causes of infectious disease mortality worldwide, increasingly complicated by the emergence of drug-resistant strains and limitations in existing diagnostic and therapeutic strategies. Despite decades of global efforts, the disease con…
Salah Al Awaidy, Faryal Khamis, Sami Al Mujeini, Jameela Al Salman, Jaffar A Al-Tawfiq
**OBJECTIVES:** Tuberculosis (TB) continues to pose a major global public health challenge. Although the Gulf Cooperation Council (GCC) countries have lower incidence rates of TB (<10 cases per million population), they are still striving to maintain and surpass benchmarks. We de…
Kassahun Dires Ayenew, Habtemariam Alekaw Habteweld, Abate Wondesen Tsige, Yihenew Sewale Bizu
…its resistance to common anti-TB drugs, multidrug-resistant tuberculosis (MDR-TB) presents substantial treatment problems. Optimizing therapeutic outcomes requires individualized treatment plans that take into account patient comorbidities, medication susceptibility profiles, and…
Hossein Jooya, Sama Yavari, Maryam Meskini, Seyyed Mohammad Amin Mousavi-Sagharchi, Seyed Davar Siadat, et al.
Tuberculosis (TB) exerts profound detrimental impacts on global human populations. This infectious disease is primarily caused by(MTB), a highly adapted pathogen that undergoes rapid genomic evolution, enabling it to acquire resistance to targeted antimicrobial agents. The emerge…
Jean de Dieu Iragena, Achilles Katamba, Dissou Affolabi, Moses Joloba, Willy Ssengooba
Tuberculosis remains a leading infectious disease killer in the World Health Organization African Region, with 2.5 million cases and 404,000 deaths in 2023, including 112,000 people with HIV. There is slow progress with only 42% of the 75% targeted reduction in death by 2025. Out…
D Boccia, K Rahevar, D J Carter, J M Pescarini, A Schwalb, et al.
…rsal social protection (SP) coverage for people affected by tuberculosis (TB) is increasingly recognised as an essential component of its response, as well as other diseases of poverty. Realising this goal requires to clearly understand the SP needs of people affected by TB and t…
María Asunción Pérez-Jacoiste Asín, Francisco López-Medrano, José María Aguado
…heart transplant recipients are particularly susceptible to tuberculosis (TB) reactivation, as they often undergo more intensive and prolonged immunosuppressive regimens compared to recipients of other organ transplants with lower immunogenicity. Additionally, the risk of do…
Gerald Mboowa
Drug-resistantremains a significant global public health threat. While whole-genome sequencing (WGS) holds immense promise for understanding transmission dynamics and drug resistance mechanisms, its integration into routine surveillance remains limited. Additionally, insights fro…
Raja Babu, Ayesha Juhi
Background and objectives Despite therapeutic advancements, patients with drug-resistant TB (DR-TB) experience substantial psychosocial challenges that adversely affect treatment adherence and outcomes. Limited research has explored these psychosocial barriers. This study aimed t…
Vincent J. C. van Winden, Edith N. G. Houben, Miriam Braunstein
…important pathogens. Most notable of these is Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Although the number of TB cases and deaths show a declining trend in the past decade, the World Health Organization recently warned that “current actions and invest…
Selvamano Selvaraj, Jayaprakash N S
Tuberculosis (TB) is a highly infectious disease caused by. The World Health Organization (WHO) has reported more than 8 million new or relapse TB cases and 1.25 million deaths in 2023. Even though the global End TB strategy implemented by WHO has reduced the TB incidence rate be…
Arjun M Menon, Abhinand Kuniyil, Shwetha Susan Thomas, S Salini, Lekshmi K Edison, et al.
Mycobacterium tuberculosis, the etiological agent of tuberculosis, is a significant worldwide health threat, especially in resource-limited environments. This review emphasizes that manipulating host metabolic and epigenetic pathways can bolster immune defences and potentially sh…
Jock McCulloch, Pavla Miller
…bstract Until 1950, there was no effective chemotherapy for tuberculosis. Treatment consisted of an enhanced diet, isolation, and skilled nursing—methods which were expensive and not greatly effective. The centrepiece of the mines’ management of tuberculosis was repatriation of s…
Nazmin Ahmed, Md. Shahidul Islam Khan, Md. Kamrul Ahsan
Spinal tuberculosis (TB) is a worldwide public health issue which is one of the main causes of disability. In regions with high TB incidence, Pott’s disease, also known as spinal tuberculosis, is also highly prevalent. Osteoarticular tuberculosis, which affects 1–2% of people wit…
Violeta Mangalagiu, Ramona Danac, Anda-Mihaela Olaru, Dumitrela Diaconu, Ionel I. Mangalagiu
During the last decades, tuberculosis (TB), a contagious disease caused by Mycobacterium tuberculosis, become a serious threat threatening against human life and, the phenomena of drug resistance, multidrug-resistant and total drug-resistant to TB complicated the situation even w…
Hannah M Gunter, Phuti Choshi, Tafadzwa Chimbetete, Sarah Pedretti, Rannakoe J Lehloenya, et al.
Tuberculosis is the leading cause of death from a single infectious agent globally, with the highest burden in low-and middle-income countries. Successful treatment requires prolonged administration of multiple drugs. The increasing threat of multidrug-resistant tuberculosis has …
Miriam Abadie, Alexander Kay
…OF REVIEW:** To summarize recent advances in drug-resistant tuberculosis (DR-TB) treatment for people with HIV (PWH), including drug-drug interactions, investigational medications and host-directed therapy, as well as emerging evidence on novel treatment regimens, post-TB complic…
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
Threatening impact of tuberculosis (TB) on public health remains significant even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same medications for several decades, ineffecti…
Ljiljana Zmak, Marija Gomercic Palcic, Mihaela Obrovac, Ivana Folnozic, Drazen Strelec, et al.
mostly spreads from active tuberculosis (TB) patients to human contacts, although human-to-animal and animal-to-human transmission has been described. Here, we present a rare case of rifampicin-resistant tuberculosis (RR-TB) transmission from a companion dog to its owner, highlig…
Muhammad Sikandar, Li Xing
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has developed different mechanism of action against antimicrobial drug therapies, posing a significant threat to effective treatment against Mtb. This review article provides an overview of the recent adv…
Shashikanta Sau, Puja Kumari Agnivesh, Arnab Roy, Sunil Kumar, Nitin Pal Kalia
Regardless of the environment, Mycobacterium tuberculosis (Mtb) relies on oxidative phosphorylation as a critical metabolic process. Because the mammalian genome lacks the NADH dehydrogenase type II (NDH-2), which serves as the entry point for electrons into the oxidative phospho…